Cellosaurus VCaP (CVCL_2235)

Cell line name VCaP
Synonyms VCAP; Vcap; Vertebral Cancer of the Prostate
Accession CVCL_2235
Resource Identification Initiative To cite this cell line use: VCaP (RRID:CVCL_2235)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Doubling time: 220 hours (PubMed=25984343); ~53 hours (ATCC).
Microsatellite instability: Stable (MSS) (PubMed=23671654; Sanger).
Omics: Deep exome analysis.
Omics: DNA methylation analysis.
Omics: shRNA library screening.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Disease Prostate carcinoma (NCIt: C4863)
Derived from metastatic site: Vertebra.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_2025 ! DuCaP
Sex of cell Male
Category Cancer cell line
STR profile Source(s): AddexBio; ATCC; Cosmic-CLP; ECACC; PubMed=14518029; PubMed=25877200

Markers:
AmelogeninX,Y
CSF1PO10,12
D13S31711,12
D16S5399
D18S5113
D21S1131
D3S135814,15
D5S81812
D7S8209,12
D8S117912,13
FGA21,26
Penta D9
Penta E10,12
TH019.3
TPOX8,11
vWA18,19
Web pages https://en.wikipedia.org/wiki/VCaP
http://capcelllines.ca/details.asp?id=159
Publications

PubMed=11317522
Korenchuk S., Lehr J.E., McLean L., Lee Y.G., Whitney S., Vessella R.L., Lin D.L., Pienta K.J.
VCaP, a cell-based model system of human prostate cancer.
In Vivo 15:163-168(2001)

PubMed=14518029; DOI=10.1002/pros.10290
van Bokhoven A., Varella-Garcia M., Korch C., Johannes W.U., Smith E.E., Miller H.L., Nordeen S.K., Miller G.J., Lucia M.S.
Molecular characterization of human prostate carcinoma cell lines.
Prostate 57:205-225(2003)

PubMed=22460905; DOI=10.1038/nature11003
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.K., Yu J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L., Winckler W., Reich M., Li N., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=23671654; DOI=10.1371/journal.pone.0063056
Lu Y., Soong T.D., Elemento O.
A novel approach for characterizing microsatellite instability in cancer cells.
PLoS ONE 8:E63056-E63056(2013)

PubMed=25984343; DOI=10.1038/sdata.2014.35
Cowley G.S., Weir B.A., Vazquez F., Tamayo P., Scott J.A., Rusin S., East-Seletsky A., Ali L.D., Gerath W.F.J., Pantel S.E., Lizotte P.H., Jiang G., Hsiao J., Tsherniak A., Dwinell E., Aoyama S., Okamoto M., Harrington W., Gelfand E., Green T.M., Tomko M.J., Gopal S., Wong T.C., Li H., Howell S., Stransky N., Liefeld T., Jang D., Bistline J., Hill Meyers B., Armstrong S.A., Anderson K.C., Stegmaier K., Reich M., Pellman D., Boehm J.S., Mesirov J.P., Golub T.R., Root D.E., Hahn W.C.
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies.
Sci. Data 1:140035-140035(2014)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

Cross-references
Cell line collections AddexBio; C0019001/73
ATCC; CRL-2876
ECACC; 06020201
IZSLER; BS TCL 234
Cell line databases/resources CCLE; VCAP_PROSTATE
Cosmic-CLP; 1299075
GDSC; 1299075
LINCS_LDP; LCL-1147
Ontologies BTO; BTO:0003215
EFO; EFO_0007752
Biological sample resources BioSample; SAMN03473238
Gene expression databases GEO; GSM525805
GEO; GSM648824
GEO; GSM887731
GEO; GSM888826
GEO; GSM1374984
GEO; GSM1440913
GEO; GSM1440914
GEO; GSM1670571
Other Wikidata; Q29511246
Polymorphism and mutation databases Cosmic; 1028646
Cosmic; 1028698
Cosmic; 1043330
Cosmic; 1071482
Cosmic; 1689710
Cosmic; 1995663
Cosmic; 2580131