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Cellosaurus VCaP (CVCL_2235)

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Cell line name VCaP
Synonyms VCAP; Vcap; Vertebral Cancer of the Prostate
Accession CVCL_2235
Resource Identification Initiative To cite this cell line use: VCaP (RRID:CVCL_2235)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Part of: COSMIC cell lines project.
Doubling time: 220 hours (PubMed=25984343); ~53 hours (ATCC); ~51 hours (PBCF).
Microsatellite instability: Stable (MSS) (PubMed=23671654; Sanger).
Omics: Deep exome analysis.
Omics: Deep RNAseq analysis.
Omics: DNA methylation analysis.
Omics: shRNA library screening.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Sequence variations TMPRSS2-ERG gene fusion (PubMed=23447416; PubMed=23615946).
Homozygous for MLH1 p.Ile219Val (c.655A>G) (PubMed=23615946).
Homozygous for TP53 p.Arg248Trp (c.742C>T) (PubMed=14518029; PubMed=23615946).
Genome ancestry Source: PubMed=30894373

Origin% genome
African0
Native American0.05
East Asian, North1.4
East Asian, South0
South Asian0.98
European, North69.8
European, South27.77
Disease Prostate carcinoma (NCIt: C4863)
Derived from metastatic site: Vertebra.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_RA58 (VCaP-EnzR)
Originate from same individual CVCL_2025 ! DuCaP
Sex of cell Male
Age at sampling 59Y
Category Cancer cell line
STR profile Source(s): AddexBio; ATCC; Cosmic-CLP; ECACC; PubMed=14518029; PubMed=25877200

Markers:
AmelogeninX,Y
CSF1PO10,12
D3S135814,15
D5S81812
D7S8209,12
D8S117912,13
D13S31711,12
D16S5399
D18S5113
D21S1131
FGA21,26
Penta D9
Penta E10,12
TH019.3
TPOX8,11
vWA18,19

Run an STR similarity search on this cell line
Web pages https://en.wikipedia.org/wiki/VCaP
https://physics.cancer.gov/docs/bioresource/prostate/NCI-PBCF-CRL2876_VCaP_SOP-508.pdf
Publications

PubMed=11317522
Korenchuk S., Lehr J.E., McLean L., Lee Y.-G., Whitney S., Vessella R.L., Lin D.L., Pienta K.J.
VCaP, a cell-based model system of human prostate cancer.
In Vivo 15:163-168(2001)

PubMed=14518029; DOI=10.1002/pros.10290
van Bokhoven A., Varella-Garcia M., Korch C., Johannes W.U., Smith E.E., Miller H.L., Nordeen S.K., Miller G.J., Lucia M.S.
Molecular characterization of human prostate carcinoma cell lines.
Prostate 57:205-225(2003)

PubMed=22460905; DOI=10.1038/nature11003
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.K., Yu J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=23447416; DOI=10.1002/path.4186
Weier C., Haffner M.C., Mosbruger T., Esopi D.M., Hicks J., Zheng Q., Fedor H., Isaacs W.B., De Marzo A.M., Nelson W.G., Yegnasubramanian S.
Nucleotide resolution analysis of TMPRSS2 and ERG rearrangements in prostate cancer.
J. Pathol. 230:174-183(2013)

PubMed=23615946; DOI=10.1007/s00439-013-1308-1
Teles Alves I., Hiltemann S., Hartjes T., van der Spek P., Stubbs A., Trapman J., Jenster G.
Gene fusions by chromothripsis of chromosome 5q in the VCaP prostate cancer cell line.
Hum. Genet. 132:709-713(2013)

PubMed=23671654; DOI=10.1371/journal.pone.0063056
Lu Y., Soong T.D., Elemento O.
A novel approach for characterizing microsatellite instability in cancer cells.
PLoS ONE 8:E63056-E63056(2013)

PubMed=25984343; DOI=10.1038/sdata.2014.35
Cowley G.S., Weir B.A., Vazquez F., Tamayo P., Scott J.A., Rusin S., East-Seletsky A., Ali L.D., Gerath W.F.J., Pantel S.E., Lizotte P.H., Jiang G., Hsiao J., Tsherniak A., Dwinell E., Aoyama S., Okamoto M., Harrington W., Gelfand E., Green T.M., Tomko M.J., Gopal S., Wong T.C., Li H., Howell S., Stransky N., Liefeld T., Jang D., Bistline J., Hill Meyers B., Armstrong S.A., Anderson K.C., Stegmaier K., Reich M., Pellman D., Boehm J.S., Mesirov J.P., Golub T.R., Root D.E., Hahn W.C.
Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies.
Sci. Data 1:140035-140035(2014)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z., Monteiro A.N., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

Cross-references
Cell line collections AddexBio; C0019001/73
ATCC; CRL-2876
ECACC; 06020201
IZSLER; BS TCL 234
Cell line databases/resources CCLE; VCAP_PROSTATE
Cell_Model_Passport; SIDM01077
Cosmic-CLP; 1299075
GDSC; 1299075
LINCS_LDP; LCL-1147
Ontologies BTO; BTO:0003215
EFO; EFO_0007752
Biological sample resources BioSample; SAMN03473238
BioSample; SAMN05292448
Gene expression databases ArrayExpress; E-MTAB-2770
ArrayExpress; E-MTAB-3610
GEO; GSM525805
GEO; GSM648824
GEO; GSM887731
GEO; GSM888826
GEO; GSM1374984
GEO; GSM1440913
GEO; GSM1440914
GEO; GSM1670571
GEO; GSM2069530
GEO; GSM2069531
GEO; GSM2069532
GEO; GSM2069533
GEO; GSM2069534
GEO; GSM2069535
GEO; GSM2069536
GEO; GSM2069537
Other Wikidata; Q29511246
Polymorphism and mutation databases Cosmic; 1028646
Cosmic; 1028698
Cosmic; 1043330
Cosmic; 1071482
Cosmic; 1689710
Cosmic; 1995663
Cosmic; 2580131
IARC_TP53; 18891
Entry history
Entry creation04-Apr-2012
Last entry updated24-May-2019
Version number24