Home  |  Contact

Cellosaurus SK-UT-1B (CVCL_2250)

[Text version]

Cell line name SK-UT-1B
Synonyms SKUT1B; SK-UT 1B; SKUT-1B; Skut1B
Accession CVCL_2250
Resource Identification Initiative To cite this cell line use: SK-UT-1B (RRID:CVCL_2250)
Comments Part of: MD Anderson Cell Lines Project.
From: Memorial Sloan Kettering Cancer Center; New York; USA.
Registration: Memorial Sloan Kettering Cancer Center Office of Technology Development; SK2010-071.
Omics: Protein expression by reverse-phase protein arrays.
Omics: Transcriptome analysis.
Sequence variations Mutation; HGNC; 583; APC; Simple; p.Gln1096Ter (c.3286C>T); ClinVar=VCV000156475; Zygosity=Heterozygous (from parent cell line).
Mutation; HGNC; 583; APC; Simple; p.Thr1556Leufs*9 (c.4666delA); ClinVar=VCV000156477; Zygosity=Heterozygous (from parent cell line).
Mutation; HGNC; 8975; PIK3CA; Simple; p.Arg88Gln (c.263G>A); ClinVar=VCV000376049; Zygosity=Heterozygous (from parent cell line).
Mutation; HGNC; 9588; PTEN; Simple; p.Thr319fs*1 (c.955_958delACTT) (p.VL317fs) (V317fs*3); Zygosity=Heterozygous (from parent cell line).
Mutation; HGNC; 9588; PTEN; Simple; p.Asn323fs*2 (c.968_969insA); Zygosity=Heterozygous (from parent cell line).
Mutation; HGNC; 9884; RB1; Simple; p.Val654Cysfs*4 (c.1959delA); Zygosity=Homozygous (from parent cell line).
Mutation; HGNC; 11998; TP53; Simple; p.Arg175His (c.524G>A); ClinVar=VCV000012374; Zygosity=Heterozygous (from parent cell line).
Mutation; HGNC; 11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Heterozygous (from parent cell line).
Disease Uterine corpus leiomyosarcoma (NCIt: C6340)
Leiomyosarcoma of the corpus uteri (ORDO: Orphanet_213625)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0533 (SK-UT-1)
Sex of cell Female
Age at sampling 75Y
Category Cancer cell line
STR profile Source(s): ATCC; CLS; PubMed=25877200

Penta D11,14
Penta E17
TPOX5,8 (PubMed=25877200)

Run an STR similarity search on this cell line
Web pages https://www.mskcc.org/research-advantage/support/technology/tangible-material/sk-ut-1b-human-uterine-leiomyosarcoma-cell-line

PubMed=327080; DOI=10.1093/jnci/59.1.221
Fogh J., Fogh J.M., Orfeo T.
One hundred and twenty-seven cultured human tumor cell lines producing tumors in nude mice.
J. Natl. Cancer Inst. 59:221-226(1977)

PubMed=6935474; DOI=10.1093/jnci/66.2.239
Wright W.C., Daniels W.P., Fogh J.
Distinction of seventy-one cultured human tumor cell lines by polymorphic enzyme analysis.
J. Natl. Cancer Inst. 66:239-247(1981)

PubMed=3518877; DOI=10.3109/07357908609038260
Fogh J.
Human tumor lines for cancer research.
Cancer Invest. 4:157-184(1986)

PubMed=3383166; DOI=10.1016/0165-4608(88)90052-0
Chen T.-R.
SK-UT-1B, a human tumorigenic diploid cell line.
Cancer Genet. Cytogenet. 33:77-81(1988)

PubMed=2766249; DOI=10.1016/0165-4608(89)90119-2
Pathak S., Dhaliwal M.K.
Cytogenetic analysis of a leiomyosarcoma cell line (SK-UT-1B). Normal diploid or with 21q deletion?
Cancer Genet. Cytogenet. 41:145-147(1989)

PubMed=2372783; DOI=10.1016/0165-4608(90)90229-4
Chen T.-R.
SK-UT-1B cell line has the diploid karyotype. A reply.
Cancer Genet. Cytogenet. 48:139-141(1990)

Polianskaia G.G., Efremova T.N., Ender N.A.
The influence of mycoplasmal contamination of the human uterine leiomyosarcoma cell line SK-UT-1B on karyotype structure.
Tsitologiia 40:23-30(1998)

PubMed=26351324; DOI=10.1158/1535-7163.MCT-15-0074
Teicher B.A., Polley E.C., Kunkel M., Evans D., Silvers T.E., Delosh R.M., Laudeman J., Ogle C., Reinhart R., Selby M., Connelly J., Harris E., Monks A., Morris J.
Sarcoma cell line screen of oncology drugs and investigational agents identifies patterns associated with gene and microRNA expression.
Mol. Cancer Ther. 14:2452-2462(2015)

PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005
Li J., Zhao W., Akbani R., Liu W.-B., Ju Z.-L., Ling S.-Y., Vellano C.P., Roebuck P., Yu Q.-H., Eterovic A.K., Byers L.A., Davies M.A., Deng W.-L., Gopal Y.N.V., Chen G., von Euw E.M., Slamon D.J., Conklin D., Heymach J.V., Gazdar A.F., Minna J.D., Myers J.N., Lu Y.-L., Mills G.B., Liang H.
Characterization of human cancer cell lines by reverse-phase protein arrays.
Cancer Cell 31:225-239(2017)

Cell line collections ATCC; HTB-115
CLS; 300406/p535_SK-UT-1B
Cell line databases/resources CLDB; cl4359
Ontologies BTO; BTO:0003725
CLO; CLO_0009066
Biological sample resources BioSample; SAMN03471096
BioSample; SAMN03472878
Chemistry resources ChEMBL-Cells; CHEMBL3307682
ChEMBL-Targets; CHEMBL614678
Gene expression databases GEO; GSM185152
GEO; GSM185153
GEO; GSM844693
GEO; GSM844694
GEO; GSM1676334
GEO; GSM1701666
Other Wikidata; Q54954651
Polymorphism and mutation databases Cosmic; 713478
Cosmic; 871555
Cosmic; 889118
Cosmic; 1007164
Cosmic; 1066227
Cosmic; 1091505
Progenetix; CVCL_2250
Entry history
Entry creation04-Apr-2012
Last entry update20-May-2021
Version number26