Cellosaurus C-4-I (CVCL_2253)

Cell line name C-4-I
Synonyms C-4I; C-4 I; C-4-i; C4-I; C4-1; C4 I; C4I; C41; Hs 636.T; Hs 636 T
Accession CVCL_2253
Resource Identification Initiative To cite this cell line use: C-4-I (RRID:CVCL_2253)
Comments Part of: Naval Biosciences Laboratory (NBL) collection (transferred to ATCC in 1982).
Characteristics: Contains a complete HPV18 genome.
Microsatellite instability: Stable (MSS) (PubMed=12661003; Sanger).
Transformant: NCBI_TaxID; 333761; Human papillomavirus type 18 (HPV18).
Omics: Deep exome analysis.
Omics: DNA methylation analysis.
Disease Human papillomavirus-related cervical squamous cell carcinoma (NCIt: C27676)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_1095 ! C-4-II
Sex of cell Female
Category Cancer cell line
STR profile Source(s): ATCC; Cosmic-CLP

Markers:
AmelogeninX
CSF1PO12
D13S31711,12
D16S53911
D5S8189,11
D7S82010,11
TH019.3
TPOX10,11
vWA14
Publications

PubMed=13863218; DOI=10.1093/jnci/28.3.605
Auersperg N., Hawryluk A.P.
Chromosome observations on three epithelial-cell cultures derived from carcinomas of the human cervix.
J. Natl. Cancer Inst. 28:605-627(1962)

PubMed=14114965; DOI=10.1093/jnci/32.1.135
Auersperg N.
Long-term cultivation of hypodiploid human tumor cells.
J. Natl. Cancer Inst. 32:135-163(1964)

PubMed=5796380; DOI=10.1093/jnci/43.1.151
Auersperg N.
Histogenetic behavior of tumors. I. Morphologic variation in vitro and in vivo of two related human carcinoma cell lines.
J. Natl. Cancer Inst. 43:151-173(1969)

PubMed=327080; DOI=10.1093/jnci/59.1.221
Fogh J., Fogh J.M., Orfeo T.
One hundred and twenty-seven cultured human tumor cell lines producing tumors in nude mice.
J. Natl. Cancer Inst. 59:221-226(1977)

PubMed=560251
Herz F., Miller O.J., Miller D.A., Auersperg N., Koss L.G.
Chromosome analysis and alkaline phosphatase of C41, a cell line of human cervical origin distinct from HeLa.
Cancer Res. 37:3209-3213(1977)

PubMed=833871; DOI=10.1093/jnci/58.2.209
Fogh J., Wright W.C., Loveless J.D.
Absence of HeLa cell contamination in 169 cell lines derived from human tumors.
J. Natl. Cancer Inst. 58:209-214(1977)

PubMed=6935474; DOI=10.1093/jnci/66.2.239
Wright W.C., Daniels W.P., Fogh J.
Distinction of seventy-one cultured human tumor cell lines by polymorphic enzyme analysis.
J. Natl. Cancer Inst. 66:239-247(1981)

PubMed=7459858
Rousset M., Zweibaum A., Fogh J.
Presence of glycogen and growth-related variations in 58 cultured human tumor cell lines of various tissue origins.
Cancer Res. 41:1165-1170(1981)

PubMed=2990217
Yee C., Krishnan-Hewlett I., Baker C.C., Schlegel R., Howley P.M.
Presence and expression of human papillomavirus sequences in human cervical carcinoma cell lines.
Am. J. Pathol. 119:361-366(1985)

PubMed=3518877; DOI=10.3109/07357908609038260
Fogh J.
Human tumor lines for cancer research.
Cancer Invest. 4:157-184(1986)

PubMed=3029760; DOI=10.1073/pnas.84.4.1070
Durst M., Croce C.M., Gissmann L., Schwarz E., Huebner K.
Papillomavirus sequences integrate near cellular oncogenes in some cervical carcinomas.
Proc. Natl. Acad. Sci. U.S.A. 84:1070-1074(1987)

PubMed=12661003; DOI=10.1002/gcc.10196
Seitz S., Wassmuth P., Plaschke J., Schackert H.K., Karsten U., Santibanez-Koref M.-F., Schlag P.M., Scherneck S.
Identification of microsatellite instability and mismatch repair gene mutations in breast cancer cell lines.
Genes Chromosomes Cancer 37:29-35(2003)

PubMed=15531914; DOI=10.1038/sj.onc.1208235
Baldus S.E., Schwarz E., Lohrey C., Zapatka M., Landsberg S., Hahn S.A., Schmidt D., Dienes H.-P., Schmiegel W.H., Schwarte-Waldhoff I.
Smad4 deficiency in cervical carcinoma cells.
Oncogene 24:810-819(2005)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

Cross-references
Cell line collections ATCC; CRL-1594
ATCC; CRL-7396 - Discontinued
ECACC; 89051702
Cell line databases/resources CLDB; cl521
Cosmic-CLP; 687506
GDSC; 687506
IGRhCellID; C4I
LINCS_LDP; LCL-1301
Ontologies CLO; CLO_0002125
CLO; CLO_0002129
EFO; EFO_0002122
Biological sample resources BioSample; SAMN03471401
Gene expression databases GEO; GSM113860
GEO; GSM253295
GEO; GSM675731
GEO; GSM685438
GEO; GSM1669639
Polymorphism and mutation databases Cosmic; 687506
Cosmic; 925358
Cosmic; 928906
Cosmic; 877471
Cosmic; 1019308
Cosmic; 1131518
Cosmic; 1193035
Cosmic; 1201771