ID   C-4-I
AC   CVCL_2253
SY   C-4I; C-4 I; C-4-i; C4-I; C4-1; C4 I; C4I; C41; Hs 636.T; Hs 636 T
DR   BTO; BTO:0006016
DR   CLO; CLO_0002125
DR   CLO; CLO_0002129
DR   EFO; EFO_0002122
DR   CLDB; cl521
DR   ArrayExpress; E-MTAB-38
DR   ArrayExpress; E-MTAB-3610
DR   ATCC; CRL-1594
DR   ATCC; CRL-7396
DR   BioSample; SAMN03471401
DR   cancercelllines; CVCL_2253
DR   Cell_Model_Passport; SIDM00905
DR   Cosmic; 687506
DR   Cosmic; 925358
DR   Cosmic; 928906
DR   Cosmic; 877471
DR   Cosmic; 1019308
DR   Cosmic; 1131518
DR   Cosmic; 1193035
DR   Cosmic; 1201771
DR   Cosmic; 2646656
DR   Cosmic; 2660189
DR   Cosmic; 2816213
DR   Cosmic-CLP; 687506
DR   DepMap; ACH-001334
DR   ECACC; 89051702
DR   EGA; EGAS00001000978
DR   GDSC; 687506
DR   GEO; GSM113860
DR   GEO; GSM253295
DR   GEO; GSM675731
DR   GEO; GSM685438
DR   GEO; GSM1669639
DR   IGRhCellID; C4I
DR   LINCS_LDP; LCL-1301
DR   PharmacoDB; C4I_151_2019
DR   PRIDE; PXD030304
DR   Progenetix; CVCL_2253
DR   Wikidata; Q54799744
RX   PubMed=77569;
RX   PubMed=327080;
RX   PubMed=560251;
RX   PubMed=833871;
RX   PubMed=2983228;
RX   PubMed=2990217;
RX   PubMed=3029760;
RX   PubMed=3518877;
RX   PubMed=5796380;
RX   PubMed=6935474;
RX   PubMed=7459858;
RX   PubMed=12661003;
RX   PubMed=13863218;
RX   PubMed=14114965;
RX   PubMed=15531914;
RX   PubMed=20215515;
RX   PubMed=27397505;
RX   PubMed=29156801;
RX   PubMed=30894373;
RX   PubMed=35692560;
RX   PubMed=35839778;
CC   Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
CC   Part of: COSMIC cell lines project.
CC   Part of: Naval Biosciences Laboratory (NBL) collection (transferred to ATCC in 1982).
CC   Population: Caucasian.
CC   Virology: Contains a complete HPV18 genome.
CC   Doubling time: 2 days (PubMed=29156801).
CC   HLA typing: A*01,03; B*07,w40 (PubMed=77569).
CC   Microsatellite instability: Stable (MSS) (PubMed=12661003; Sanger).
CC   Transformant: NCBI_TaxID; 333761; Human papillomavirus type 18 (HPV18).
CC   Omics: Deep exome analysis.
CC   Omics: Deep quantitative proteome analysis.
CC   Omics: DNA methylation analysis.
CC   Omics: Protein expression by reverse-phase protein arrays.
CC   Omics: SNP array analysis.
CC   Omics: Transcriptome analysis by microarray.
CC   Omics: Transcriptome analysis by RNAseq.
CC   Genome ancestry: African=0%; Native American=0.73%; East Asian, North=0%; East Asian, South=0%; South Asian=1.02%; European, North=72.49%; European, South=25.76% (PubMed=30894373).
CC   Discontinued: ATCC; CRL-7396; true.
CC   Derived from site: In situ; Uterus, cervix; UBERON=UBERON_0000002.
ST   Source(s): ATCC; Cosmic-CLP; DepMap; PubMed=29156801
ST   Amelogenin: X
ST   CSF1PO: 12
ST   D13S317: 11,12
ST   D16S539: 11
ST   D18S51: 14
ST   D21S11: 29,30
ST   D3S1358: 16,17
ST   D5S818: 9,11
ST   D7S820: 10,11
ST   D8S1179: 14,15
ST   FGA: 25
ST   Penta D: 9,13
ST   Penta E: 19
ST   TH01: 9.3
ST   TPOX: 10,11
ST   vWA: 14
DI   NCIt; C27676; Human papillomavirus-related cervical squamous cell carcinoma
DI   ORDO; Orphanet_213767; Squamous cell carcinoma of the cervix uteri
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
OI   CVCL_1095 ! C-4-II
SX   Female
AG   41Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 05-10-23; Version: 34
//
RX   PubMed=77569; DOI=10.1111/j.1399-0039.1978.tb01259.x;
RA   Espmark J.A., Ahlqvist-Roth L., Sarne L., Persson A.;
RT   "Tissue typing of cells in culture. III. HLA antigens of established
RT   human cell lines. Attempts at typing by the mixed hemadsorption
RT   technique.";
RL   Tissue Antigens 11:279-286(1978).
//
RX   PubMed=327080; DOI=10.1093/jnci/59.1.221;
RA   Fogh J., Fogh J.M., Orfeo T.;
RT   "One hundred and twenty-seven cultured human tumor cell lines
RT   producing tumors in nude mice.";
RL   J. Natl. Cancer Inst. 59:221-226(1977).
//
RX   PubMed=560251;
RA   Herz F., Miller O.J., Miller D.A., Auersperg N., Koss L.G.;
RT   "Chromosome analysis and alkaline phosphatase of C41, a cell line of
RT   human cervical origin distinct from HeLa.";
RL   Cancer Res. 37:3209-3213(1977).
//
RX   PubMed=833871; DOI=10.1093/jnci/58.2.209;
RA   Fogh J., Wright W.C., Loveless J.D.;
RT   "Absence of HeLa cell contamination in 169 cell lines derived from
RT   human tumors.";
RL   J. Natl. Cancer Inst. 58:209-214(1977).
//
RX   PubMed=2983228; DOI=10.1038/314111a0;
RA   Schwarz E., Freese U.-K., Gissmann L., Mayer W., Roggenbuck B.,
RA   Stremlau A., zur Hausen H.;
RT   "Structure and transcription of human papillomavirus sequences in
RT   cervical carcinoma cells.";
RL   Nature 314:111-114(1985).
//
RX   PubMed=2990217;
RA   Yee C., Krishnan-Hewlett I., Baker C.C., Schlegel R., Howley P.M.;
RT   "Presence and expression of human papillomavirus sequences in human
RT   cervical carcinoma cell lines.";
RL   Am. J. Pathol. 119:361-366(1985).
//
RX   PubMed=3029760; DOI=10.1073/pnas.84.4.1070;
RA   Durst M., Croce C.M., Gissmann L., Schwarz E., Huebner K.;
RT   "Papillomavirus sequences integrate near cellular oncogenes in some
RT   cervical carcinomas.";
RL   Proc. Natl. Acad. Sci. U.S.A. 84:1070-1074(1987).
//
RX   PubMed=3518877; DOI=10.3109/07357908609038260;
RA   Fogh J.;
RT   "Human tumor lines for cancer research.";
RL   Cancer Invest. 4:157-184(1986).
//
RX   PubMed=5796380; DOI=10.1093/jnci/43.1.151;
RA   Auersperg N.;
RT   "Histogenetic behavior of tumors. I. Morphologic variation in vitro
RT   and in vivo of two related human carcinoma cell lines.";
RL   J. Natl. Cancer Inst. 43:151-173(1969).
//
RX   PubMed=6935474; DOI=10.1093/jnci/66.2.239;
RA   Wright W.C., Daniels W.P., Fogh J.;
RT   "Distinction of seventy-one cultured human tumor cell lines by
RT   polymorphic enzyme analysis.";
RL   J. Natl. Cancer Inst. 66:239-247(1981).
//
RX   PubMed=7459858;
RA   Rousset M., Zweibaum A., Fogh J.;
RT   "Presence of glycogen and growth-related variations in 58 cultured
RT   human tumor cell lines of various tissue origins.";
RL   Cancer Res. 41:1165-1170(1981).
//
RX   PubMed=12661003; DOI=10.1002/gcc.10196;
RA   Seitz S., Wassmuth P., Plaschke J., Schackert H.K., Karsten U.,
RA   Santibanez-Koref M.F., Schlag P.M., Scherneck S.;
RT   "Identification of microsatellite instability and mismatch repair gene
RT   mutations in breast cancer cell lines.";
RL   Genes Chromosomes Cancer 37:29-35(2003).
//
RX   PubMed=13863218; DOI=10.1093/jnci/28.3.605;
RA   Auersperg N., Hawryluk A.P.;
RT   "Chromosome observations on three epithelial-cell cultures derived
RT   from carcinomas of the human cervix.";
RL   J. Natl. Cancer Inst. 28:605-627(1962).
//
RX   PubMed=14114965; DOI=10.1093/jnci/32.1.135;
RA   Auersperg N.;
RT   "Long-term cultivation of hypodiploid human tumor cells.";
RL   J. Natl. Cancer Inst. 32:135-163(1964).
//
RX   PubMed=15531914; DOI=10.1038/sj.onc.1208235;
RA   Baldus S.E., Schwarz E., Lohrey C., Zapatka M., Landsberg S.,
RA   Hahn S.A., Schmidt D., Dienes H.-P., Schmiegel W.H.,
RA   Schwarte-Waldhoff I.;
RT   "Smad4 deficiency in cervical carcinoma cells.";
RL   Oncogene 24:810-819(2005).
//
RX   PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458;
RA   Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P.,
RA   Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J.,
RA   Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C.,
RA   Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J.,
RA   Haber D.A.;
RT   "A genome-wide screen for microdeletions reveals disruption of
RT   polarity complex genes in diverse human cancers.";
RL   Cancer Res. 70:2158-2164(2010).
//
RX   PubMed=27397505; DOI=10.1016/j.cell.2016.06.017;
RA   Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P.,
RA   Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H.,
RA   Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H.,
RA   Deng X.-M., Egan R.K., Liu Q.-S., Mironenko T., Mitropoulos X.,
RA   Richardson L., Wang J.-H., Zhang T.-H., Moran S., Sayols S.,
RA   Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P.,
RA   Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H.,
RA   Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.;
RT   "A landscape of pharmacogenomic interactions in cancer.";
RL   Cell 166:740-754(2016).
//
RX   PubMed=29156801; DOI=10.18632/oncotarget.21174;
RA   Kalu N.N., Mazumdar T., Peng S.-H., Shen L., Sambandam V., Rao X.-Y.,
RA   Xi Y.-X., Li L.-R., Qi Y., Gleber-Netto F.O., Patel A., Wang J.,
RA   Frederick M.J., Myers J.N., Pickering C.R., Johnson F.M.;
RT   "Genomic characterization of human papillomavirus-positive and
RT   -negative human squamous cell cancer cell lines.";
RL   Oncotarget 8:86369-86383(2017).
//
RX   PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747;
RA   Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.;
RT   "An interactive resource to probe genetic diversity and estimated
RT   ancestry in cancer cell lines.";
RL   Cancer Res. 79:1263-1273(2019).
//
RX   PubMed=35692560; DOI=10.1080/23723556.2022.2078628;
RA   de Lourdes Zuniga-Martinez M., Lopez-Mendoza C.M., Tenorio-Salazar J.,
RA   Garcia-Carranca A.M., Cerbon-Cervantes M.A., Alcantara-Quintana L.E.;
RT   "Establishment, authenticity, and characterization of cervical cancer
RT   cell lines.";
RL   Mol. Cell. Oncol. 9:2078628.1-2078628.10(2022).
//
RX   PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010;
RA   Goncalves E., Poulos R.C., Cai Z.-X., Barthorpe S., Manda S.S., Lucas N.,
RA   Beck A., Bucio-Noble D., Dausmann M., Hall C., Hecker M., Koh J.,
RA   Lightfoot H., Mahboob S., Mali I., Morris J., Richardson L.,
RA   Seneviratne A.J., Shepherd R., Sykes E., Thomas F., Valentini S.,
RA   Williams S.G., Wu Y.-X., Xavier D., MacKenzie K.L., Hains P.G., Tully B.,
RA   Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.;
RT   "Pan-cancer proteomic map of 949 human cell lines.";
RL   Cancer Cell 40:835-849.e8(2022).
//