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Cellosaurus 1301 (CVCL_2265)

[Text version]

Cell line name 1301
Accession CVCL_2265
Resource Identification Initiative To cite this cell line use: 1301 (RRID:CVCL_2265)
Comments Population: Caucasian.
Characteristics: Has unusually long telomeres.
Derived from sampling site: Peripheral blood. Cell type=T-cell.
Sequence variations
  • Gene fusion; HGNC; 13222; BCL11B + HGNC; 2488; NKX2-5; Name(s)=NKX2.5-BCL11B (from parent cell line).
  • Mutation; HGNC; 16712; FBXW7; Simple; p.Arg465Cys (c.1393C>T); ClinVar=VCV000376414; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 3765; FLT3; Simple; p.Ala627Thr (c.1879G>A); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 6407; KRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000012582; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 7881; NOTCH1; Simple; p.Leu1593_Arg1594insProArgLeuProHisAsnSerSerPheHisPheLeu (c.4780_4781ins36); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 7881; NOTCH1; Simple; p.Pro2412Thr (c.7234C>A); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg175His (c.524G>A); ClinVar=VCV000012374; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Heterozygous (from parent cell line).
Disease Childhood T acute lymphoblastic leukemia (NCIt: C7953)
Precursor T-cell acute lymphoblastic leukemia (ORDO: Orphanet_99861)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0207 (CCRF-CEM)
Children:
CVCL_IS05 (1301-U1 )CVCL_IS06 (1301-U2 )
Sex of cell Female
Age at sampling 3Y11M
Category Cancer cell line
STR profile Source(s): ICLC

Markers:
AmelogeninX
CSF1PO10,13
D5S81812,14,15
D7S82010
D13S3179
D16S53910,13
D21S1130,32.2,33.2
TH016,7
TPOX8
vWA17,18,19

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Publications

PubMed=223921
Larsson I., Lundgren E., Nilsson K., Strannegard O.
A human neoplastic hematopoietic cell line producing a fibroblast type of interferon.
Dev. Biol. Stand. 42:193-197(1979)

PubMed=9685479; DOI=10.1093/nar/26.16.3651
Hultdin M., Gronlund E., Norrback K.-F., Eriksson-Lindstrom E., Just T., Roos G.
Telomere analysis by fluorescence in situ hybridization and flow cytometry.
Nucleic Acids Res. 26:3651-3656(1998)

Cross-references
Cell line collections ECACC; 01051619
ICLC; HTL01004
NCBI_Iran; C512
Cell line databases/resources CLO; CLO_0001010
CLDB; cl5401
Encyclopedic resources Wikidata; Q54581450
Polymorphism and mutation databases Cosmic; 2402466
IARC_TP53; 21147
Entry history
Entry creation04-Apr-2012
Last entry update23-Jun-2022
Version number24