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Cellosaurus 143B (CVCL_2270)

[Text version]

Cell line name 143B
Synonyms 143b; 143 B; 143B TK-; 143BTK-; 143TK-; HOS-143B; HOS-143b; GM05887; GM05887A
Accession CVCL_2270
Resource Identification Initiative To cite this cell line use: 143B (RRID:CVCL_2270)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Omics: Deep exome analysis.
Omics: H3K4me1 ChIP-seq epigenome analysis.
Omics: H3K27ac ChIP-seq epigenome analysis.
Omics: Deep RNAseq analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Caution: Could be identical to HTK- (CVCL_2522).
Misspelling: I43B; In Cosmic 1529910.
Sequence variations Homozygous for CDKN2A deletion (PubMed=19787792).
Heterozygous for KRAS p.Gly12Ser (c.34G>A) and p.Ala59Thr (c.175G>A) (DepMap).
Homozygous for TP53 p.Arg156Pro (c.467G>C) (PubMed=19787792; DepMap).
Genome ancestry Source: PubMed=30894373

Origin% genome
African0
Native American0
East Asian, North0
East Asian, South4.02
South Asian37
European, North0
European, South58.98
Disease Osteosarcoma (NCIt: C9145)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0312 (HOS)
Children:
CVCL_3476 (143.98.2)CVCL_3477 (143B pML BK TK)CVCL_XF76 (143B rho-0#25)
CVCL_9W36 (143BTK-)CVCL_U923 (143B.206)CVCL_IW03 (GM16530)
Sex of cell Female
Age at sampling 13Y
Category Cancer cell line
STR profile Source(s): ATCC; CCRID; ECACC; PubMed=19787792; PubMed=25877200

Markers:
AmelogeninX
CSF1PO12
D2S133824,25
D3S135815
D5S81813 (ATCC; CCRID; ECACC; PubMed=25877200)
13,14 (PubMed=19787792)
D7S82011,12
D8S117911,14
D13S31712
D16S53910,13
D18S5117
D19S43313
D21S1131.2,32.2
FGA24
Penta D9,10
Penta E7,12
SE3321
TH016
TPOX11
vWA18 (ATCC; CCRID; ECACC; PubMed=25877200)
18,19 (PubMed=19787792)

Run an STR similarity search on this cell line
Web pages http://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/1/cell-lines-detail-310.html
http://www.cellresource.cn/fdetail.aspx?id=843
http://www.cellresource.cn/fdetail.aspx?id=1552
Publications

CLPUB00447
Mulivor R.A., Suchy S.F.
1992/1993 catalog of cell lines. NIGMS human genetic mutant cell repository. 16th edition. October 1992.
(In) Institute for Medical Research (Camden, N.J.) NIH 92-2011; pp.1-918; National Institutes of Health; Bethesda (1992)

PubMed=19787792; DOI=10.1002/gcc.20717
Ottaviano L., Schaefer K.-L., Gajewski M., Huckenbeck W., Baldus S., Rogel U., Mackintosh C., de Alava E., Myklebost O., Kresse S.H., Meza-Zepeda L.A., Serra M., Cleton-Jansen A.-M., Hogendoorn P.C.W., Buerger H., Aigner T., Gabbert H.E., Poremba C.
Molecular characterization of commonly used cell lines for bone tumor research: a trans-European EuroBoNet effort.
Genes Chromosomes Cancer 49:40-51(2010)

PubMed=21519327; DOI=10.1038/labinvest.2011.72
Mohseny A.B., Machado I., Cai Y., Schaefer K.-L., Serra M., Hogendoorn P.C.W., Llombart-Bosch A., Cleton-Jansen A.-M.
Functional characterization of osteosarcoma cell lines provides representative models to study the human disease.
Lab. Invest. 91:1195-1205(2011)

PubMed=22460905; DOI=10.1038/nature11003
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.K., Yu J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=25485619; DOI=10.1038/nbt.3080
Klijn C., Durinck S., Stawiski E.W., Haverty P.M., Jiang Z., Liu H., Degenhardt J., Mayba O., Gnad F., Liu J., Pau G., Reeder J., Cao Y., Mukhyala K., Selvaraj S.K., Yu M., Zynda G.J., Brauer M.J., Wu T.D., Gentleman R.C., Manning G., Yauch R.L., Bourgon R., Stokoe D., Modrusan Z., Neve R.M., de Sauvage F.J., Settleman J., Seshagiri S., Zhang Z.
A comprehensive transcriptional portrait of human cancer cell lines.
Nat. Biotechnol. 33:306-312(2015)

PubMed=26320182; DOI=10.18632/oncotarget.5177
Ren L., Mendoza A., Zhu J., Briggs J.W., Halsey C., Hong E.S., Burkett S.S., Morrow J., Lizardo M.M., Osborne T., Li S.Q., Luu H.H., Meltzer P., Khanna C.
Characterization of the metastatic phenotype of a panel of established osteosarcoma cells.
Oncotarget 6:29469-29481(2015)

PubMed=29334376; DOI=10.1038/nm.4475
Morrow J.J., Bayles I., Funnell A.P.W., Miller T.E., Saiakhova A., Lizardo M.M., Bartels C.F., Kapteijn M.Y., Hung S., Mendoza A., Dhillon G., Chee D.R., Myers J.T., Allen F., Gambarotti M., Righi A., DiFeo A., Rubin B.P., Huang A.Y., Meltzer P.S., Helman L.J., Picci P., Versteeg H.H., Stamatoyannopoulos J.A., Khanna C., Scacheri P.C.
Positively selected enhancer elements endow osteosarcoma cells with metastatic competence.
Nat. Med. 24:176-185(2018)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z., Monteiro A.N., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3
Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. III, Barretina J., Gelfand E.T., Bielski C.M., Li H., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R.
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

Cross-references
Cell line collections ATCC; CRL-8303
BCRC; 60439
CCTCC; GDC0076
Coriell; GM05887
ECACC; 91112502
IZSLER; BS TCL 77
Cell line databases/resources CLDB; cl10
CLDB; cl11
CCLE; 143B_BONE
CCRID; 3111C0001CCC000363
CCRID; 3142C0001000000075
Cell_Model_Passport; SIDM00804
DepMap; ACH-001001
LINCS_LDP; LCL-1417
Lonza; 136
TOKU-E; 132
Ontologies BTO; BTO:0003167
CLO; CLO_0001084
CLO; CLO_0001088
CLO; CLO_0024221
EFO; EFO_0006355
Biological sample resources BioSample; SAMN03471904
Chemistry resources ChEMBL-Cells; CHEMBL3307382
ChEMBL-Targets; CHEMBL614508
PharmacoDB; 143B_3_2019
Gene expression databases ArrayExpress; E-MTAB-2706
GEO; GSM320829
GEO; GSM879206
GEO; GSM886836
GEO; GSM887899
GEO; GSM1914980
GEO; GSM1914981
GEO; GSM1914982
GEO; GSM1914983
GEO; GSM1915018
GEO; GSM1915019
GEO; GSM1915020
GEO; GSM1915021
GEO; GSM1915022
GEO; GSM2635309
GEO; GSM2635310
Other Wikidata; Q54581813
Polymorphism and mutation databases Cosmic; 1074398
Cosmic; 1529910
Cosmic; 2009541
IARC_TP53; 21149
IARC_TP53; 27023
Entry history
Entry creation04-Apr-2012
Last entry updated06-Sep-2019
Version number27