ID   BICR 10
AC   CVCL_2307
SY   BICR-10; BICR10; BICR-10 R; Beatson Institute for Cancer Research 10
DR   EFO; EFO_0006540
DR   ArrayExpress; E-MTAB-2706
DR   ArrayExpress; E-MTAB-3610
DR   BioSample; SAMN03473143
DR   CCLE; BICR10_UPPER_AERODIGESTIVE_TRACT
DR   Cell_Model_Passport; SIDM00077
DR   Cosmic-CLP; 1290724
DR   DepMap; ACH-001331
DR   ECACC; 04072103
DR   GDSC; 1290724
DR   GEO; GSM827321
DR   GEO; GSM1669621
DR   LINCS_LDP; LCL-1203
DR   PharmacoDB; BICR10_93_2019
DR   Progenetix; CVCL_2307
DR   Wikidata; Q54796517
DR   Ximbio; 152841
RX   PubMed=7646764;
RX   PubMed=8390283;
RX   PubMed=9307265;
RX   PubMed=10523844;
RX   PubMed=20215515;
RX   PubMed=25485619;
RX   PubMed=27397505;
RX   PubMed=30894373;
CC   Part of: Cancer Cell Line Encyclopedia (CCLE) project.
CC   Part of: COSMIC cell lines project.
CC   Microsatellite instability: Stable (MSS) (Sanger).
CC   Omics: Deep exome analysis.
CC   Omics: Deep RNAseq analysis.
CC   Omics: DNA methylation analysis.
CC   Omics: SNP array analysis.
CC   Omics: Transcriptome analysis.
CC   Genome ancestry: African=0.05%; Native American=0%; East Asian, North=0.01%; East Asian, South=0%; South Asian=0.82%; European, North=71.25%; European, South=27.87% (PubMed=30894373).
ST   Source(s): Cosmic-CLP; ECACC; PubMed=25877200
ST   Amelogenin: X
ST   CSF1PO: 12,14
ST   D13S317: 8,14
ST   D16S539: 9,13
ST   D18S51: 14,19
ST   D21S11: 30.2,32.2
ST   D3S1358: 17
ST   D5S818: 11,13
ST   D7S820: 11,12
ST   D8S1179: 13,14
ST   FGA: 21,22
ST   Penta D: 9,12
ST   Penta E: 7,18
ST   TH01: 9.3
ST   TPOX: 8
ST   vWA: 17
DI   NCIt; C4040; Buccal mucosa squamous cell carcinoma
DI   ORDO; Orphanet_502363; Squamous cell carcinoma of the oral cavity
OX   NCBI_TaxID=9606; ! Homo sapiens
SX   Female
AG   Age unspecified
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 29-10-20; Version: 25
//
RX   PubMed=7646764; DOI=10.1002/mc.2940130408;
RA   Edington K.G., Loughran O.P., Berry I.J., Parkinson E.K.;
RT   "Cellular immortality: a late event in the progression of human
RT   squamous cell carcinoma of the head and neck associated with p53
RT   alteration and a high frequency of allele loss.";
RL   Mol. Carcinog. 13:254-265(1995).
//
RX   PubMed=8390283; DOI=10.1038/bjc.1993.238;
RA   Burns J.E., Baird M.C., Clark L.J., Burns P.A., Edington K.G.,
RA   Chapman C., Mitchell R., Robertson G., Soutar D., Parkinson E.K.;
RT   "Gene mutations and increased levels of p53 protein in human squamous
RT   cell carcinomas and their cell lines.";
RL   Br. J. Cancer 67:1274-1284(1993).
//
RX   PubMed=9307265;
RA   McGregor F., Wagner E., Felix D.H., Soutar D., Parkinson E.K.,
RA   Harrison P.R.;
RT   "Inappropriate retinoic acid receptor-beta expression in oral
RT   dysplasias: correlation with acquisition of the immortal phenotype.";
RL   Cancer Res. 57:3886-3889(1997).
//
RX   PubMed=10523844; DOI=10.1038/sj.onc.1202957;
RA   Agochiya M., Brunton V.G., Owens D.W., Parkinson E.K., Paraskeva C.,
RA   Keith W.N., Frame M.C.;
RT   "Increased dosage and amplification of the focal adhesion kinase gene
RT   in human cancer cells.";
RL   Oncogene 18:5646-5653(1999).
//
RX   PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458;
RA   Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P.,
RA   Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J.,
RA   Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C.,
RA   Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J.,
RA   Haber D.A.;
RT   "A genome-wide screen for microdeletions reveals disruption of
RT   polarity complex genes in diverse human cancers.";
RL   Cancer Res. 70:2158-2164(2010).
//
RX   PubMed=25485619; DOI=10.1038/nbt.3080;
RA   Klijn C., Durinck S., Stawiski E.W., Haverty P.M., Jiang Z., Liu H.,
RA   Degenhardt J., Mayba O., Gnad F., Liu J., Pau G., Reeder J., Cao Y.,
RA   Mukhyala K., Selvaraj S.K., Yu M., Zynda G.J., Brauer M.J., Wu T.D.,
RA   Gentleman R.C., Manning G., Yauch R.L., Bourgon R., Stokoe D.,
RA   Modrusan Z., Neve R.M., de Sauvage F.J., Settleman J., Seshagiri S.,
RA   Zhang Z.;
RT   "A comprehensive transcriptional portrait of human cancer cell
RT   lines.";
RL   Nat. Biotechnol. 33:306-312(2015).
//
RX   PubMed=27397505; DOI=10.1016/j.cell.2016.06.017;
RA   Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P.,
RA   Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H.,
RA   Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H.,
RA   Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X.,
RA   Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M.,
RA   Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M.,
RA   Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A.,
RA   Saez-Rodriguez J., McDermott U., Garnett M.J.;
RT   "A landscape of pharmacogenomic interactions in cancer.";
RL   Cell 166:740-754(2016).
//
RX   PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747;
RA   Dutil J., Chen Z., Monteiro A.N., Teer J.K., Eschrich S.A.;
RT   "An interactive resource to probe genetic diversity and estimated
RT   ancestry in cancer cell lines.";
RL   Cancer Res. 79:1263-1273(2019).
//