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Cellosaurus BICR 22 (CVCL_2310)

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Cell line name BICR 22
Synonyms BICR-22; BICR22; BICR-22 M; Beatson Institute for Cancer Research 22
Accession CVCL_2310
Resource Identification Initiative To cite this cell line use: BICR 22 (RRID:CVCL_2310)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Part of: COSMIC cell lines project.
Part of: OPC-22 oral and pharyngeal cancer cell line panel.
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Deep exome analysis.
Omics: Deep RNAseq analysis.
Omics: DNA methylation analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Sequence variations TP53 p.Gly325_Ile332del (PubMed=25275298).
Genome ancestry Source: PubMed=30894373

Origin% genome
African9.32
Native American0
East Asian, North10.18
East Asian, South0
South Asian0
European, North36.79
European, South43.71
Disease Tongue squamous cell carcinoma (NCIt: C4648)
Derived from metastatic site: Lymph node.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 88Y
Category Cancer cell line
STR profile Source(s): Cosmic-CLP; ECACC; PubMed=25275298; PubMed=25877200

Markers:
AmelogeninX
CSF1PO11
D3S135815
D5S81811,12
D7S82011,12
D8S117910,15
D13S31711,13
D16S53911,12
D18S5114
D21S1128,31
FGA24 (PubMed=25275298)
23,24 (PubMed=25877200)
Penta D9,13
Penta E12,14
TH016,7
TPOX8
vWA16,19

Run an STR similarity search on this cell line
Publications

PubMed=8390283; DOI=10.1038/bjc.1993.238
Burns J.E., Baird M.C., Clark L.J., Burns P.A., Edington K.G., Chapman C., Mitchell R., Robertson G., Soutar D., Parkinson E.K.
Gene mutations and increased levels of p53 protein in human squamous cell carcinomas and their cell lines.
Br. J. Cancer 67:1274-1284(1993)

PubMed=7646764; DOI=10.1002/mc.2940130408
Edington K.G., Loughran O.P., Berry I.J., Parkinson E.K.
Cellular immortality: a late event in the progression of human squamous cell carcinoma of the head and neck associated with p53 alteration and a high frequency of allele loss.
Mol. Carcinog. 13:254-265(1995)

PubMed=9150362; DOI=10.1038/sj.onc.1201028
Loughran O.P., Clark L.J., Bond J., Baker A., Berry I.J., Edington K.G., Ly I.-S., Simmons R., Haw R., Black D.M., Newbold R.F., Parkinson E.K.
Evidence for the inactivation of multiple replicative lifespan genes in immortal human squamous cell carcinoma keratinocytes.
Oncogene 14:1955-1964(1997)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458
Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A.
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=22460905; DOI=10.1038/nature11003
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.K., Yu J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=25275298; DOI=10.18632/oncotarget.2417
Martin D., Abba M.C., Molinolo A.A., Vitale-Cross L., Wang Z., Zaida M., Delic N.C., Samuels Y., Lyons J.G., Gutkind J.S.
The head and neck cancer cell oncogenome: a platform for the development of precision molecular therapies.
Oncotarget 5:8906-8923(2014)

PubMed=25485619; DOI=10.1038/nbt.3080
Klijn C., Durinck S., Stawiski E.W., Haverty P.M., Jiang Z., Liu H., Degenhardt J., Mayba O., Gnad F., Liu J., Pau G., Reeder J., Cao Y., Mukhyala K., Selvaraj S.K., Yu M., Zynda G.J., Brauer M.J., Wu T.D., Gentleman R.C., Manning G., Yauch R.L., Bourgon R., Stokoe D., Modrusan Z., Neve R.M., de Sauvage F.J., Settleman J., Seshagiri S., Zhang Z.
A comprehensive transcriptional portrait of human cancer cell lines.
Nat. Biotechnol. 33:306-312(2015)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z., Monteiro A.N., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3
Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. III, Barretina J., Gelfand E.T., Bielski C.M., Li H., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R.
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

Cross-references
Cell line collections ECACC; 04072106
Ximbio; 152844
Cell line databases/resources CCLE; BICR22_UPPER_AERODIGESTIVE_TRACT
Cell_Model_Passport; SIDM00485
Cosmic-CLP; 1240121
DepMap; ACH-000794
GDSC; 1240121
LINCS_LDP; LCL-1213
Ontologies EFO; EFO_0006541
Biological sample resources BioSample; SAMN03473144
BioSample; SAMN10987716
Chemistry resources PharmacoDB; BICR22_96_2019
Gene expression databases ArrayExpress; E-MTAB-2706
ArrayExpress; E-MTAB-2770
ArrayExpress; E-MTAB-3610
GEO; GSM827154
GEO; GSM886885
GEO; GSM887950
GEO; GSM1669622
Other Wikidata; Q54796527
Polymorphism and mutation databases Cosmic; 1995345
Cosmic; 2296291
LiGeA; CCLE_493
Entry history
Entry creation04-Apr-2012
Last entry updated06-Sep-2019
Version number24