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Cellosaurus BICR 3 (CVCL_2311)

[Text version]
Cell line name BICR 3
Synonyms BICR-3; BICR3; Beatson Institute for Cancer Research 3
Accession CVCL_2311
Resource Identification Initiative To cite this cell line use: BICR 3 (RRID:CVCL_2311)
Comments Population: Caucasian.
Derived from site: In situ; Oral cavity, alveolar ridge; UBERON=UBERON_0004102.
Sequence variations
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg282Pro (c.845G>C); ClinVar=VCV000376659; Zygosity=Unspecified (PubMed=8390283).
Disease Alveolar ridge squamous cell carcinoma (NCIt: C170774)
Squamous cell carcinoma of the oral cavity (ORDO: Orphanet_502363)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling Age unspecified
Category Cancer cell line
STR profile Source(s): ECACC

Markers:
AmelogeninX
CSF1PO11,12
D5S81811,12
D7S82010,13
D13S3178,13
D16S53911
TH016,7
TPOX8
vWA14,19

Run an STR similarity search on this cell line
Publications

PubMed=8390283; DOI=10.1038/bjc.1993.238
Burns J.E., Baird M.C., Clark L.J., Burns P.A., Edington K.G., Chapman C., Mitchell R., Robertson G., Soutar D., Parkinson E.K.
Gene mutations and increased levels of p53 protein in human squamous cell carcinomas and their cell lines.
Br. J. Cancer 67:1274-1284(1993)

PubMed=7646764; DOI=10.1002/mc.2940130408
Edington K.G., Loughran O.P., Berry I.J., Parkinson E.K.
Cellular immortality: a late event in the progression of human squamous cell carcinoma of the head and neck associated with p53 alteration and a high frequency of allele loss.
Mol. Carcinog. 13:254-265(1995)

PubMed=9150362; DOI=10.1038/sj.onc.1201028
Loughran O.P., Clark L.J., Bond J., Baker A., Berry I.J., Edington K.G., Ly I.-S., Simmons R., Haw R., Black D.M., Newbold R.F., Parkinson E.K.
Evidence for the inactivation of multiple replicative lifespan genes in immortal human squamous cell carcinoma keratinocytes.
Oncogene 14:1955-1964(1997)

PubMed=10523844; DOI=10.1038/sj.onc.1202957
Agochiya M., Brunton V.G., Owens D.W., Parkinson E.K., Paraskeva C., Keith W.N., Frame M.C.
Increased dosage and amplification of the focal adhesion kinase gene in human cancer cells.
Oncogene 18:5646-5653(1999)

Cross-references
Cell line collections (Providers) CancerTools; 152845
ECACC; 06032203
Ximbio; 152845
Cell line databases/resources cancercelllines; CVCL_2311
Encyclopedic resources Wikidata; Q54796529
Polymorphism and mutation databases Cosmic; 848752
Entry history
Entry creation04-Apr-2012
Last entry update05-Oct-2023
Version number18