ID   BICR 3
AC   CVCL_2311
SY   BICR-3; BICR3; Beatson Institute for Cancer Research 3
DR   cancercelllines; CVCL_2311
DR   CancerTools; 152845
DR   Cosmic; 848752
DR   ECACC; 06032203
DR   Wikidata; Q54796529
DR   Ximbio; 152845
RX   PubMed=7646764;
RX   PubMed=8390283;
RX   PubMed=9150362;
RX   PubMed=10523844;
CC   Population: Caucasian.
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Arg282Pro (c.845G>C); ClinVar=VCV000376659; Zygosity=Unspecified (PubMed=8390283).
CC   Derived from site: In situ; Oral cavity, alveolar ridge; UBERON=UBERON_0004102.
ST   Source(s): ECACC
ST   Amelogenin: X
ST   CSF1PO: 11,12
ST   D13S317: 8,13
ST   D16S539: 11
ST   D5S818: 11,12
ST   D7S820: 10,13
ST   TH01: 6,7
ST   TPOX: 8
ST   vWA: 14,19
DI   NCIt; C170774; Alveolar ridge squamous cell carcinoma
DI   ORDO; Orphanet_502363; Squamous cell carcinoma of the oral cavity
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   Age unspecified
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 05-10-23; Version: 18
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RX   PubMed=7646764; DOI=10.1002/mc.2940130408;
RA   Edington K.G., Loughran O.P., Berry I.J., Parkinson E.K.;
RT   "Cellular immortality: a late event in the progression of human
RT   squamous cell carcinoma of the head and neck associated with p53
RT   alteration and a high frequency of allele loss.";
RL   Mol. Carcinog. 13:254-265(1995).
//
RX   PubMed=8390283; DOI=10.1038/bjc.1993.238;
RA   Burns J.E., Baird M.C., Clark L.J., Burns P.A., Edington K.G.,
RA   Chapman C., Mitchell R., Robertson G., Soutar D., Parkinson E.K.;
RT   "Gene mutations and increased levels of p53 protein in human squamous
RT   cell carcinomas and their cell lines.";
RL   Br. J. Cancer 67:1274-1284(1993).
//
RX   PubMed=9150362; DOI=10.1038/sj.onc.1201028;
RA   Loughran O.P., Clark L.J., Bond J., Baker A., Berry I.J., Edington K.G.,
RA   Ly I.-S., Simmons R., Haw R., Black D.M., Newbold R.F.,
RA   Parkinson E.K.;
RT   "Evidence for the inactivation of multiple replicative lifespan genes
RT   in immortal human squamous cell carcinoma keratinocytes.";
RL   Oncogene 14:1955-1964(1997).
//
RX   PubMed=10523844; DOI=10.1038/sj.onc.1202957;
RA   Agochiya M., Brunton V.G., Owens D.W., Parkinson E.K., Paraskeva C.,
RA   Keith W.N., Frame M.C.;
RT   "Increased dosage and amplification of the focal adhesion kinase gene
RT   in human cancer cells.";
RL   Oncogene 18:5646-5653(1999).
//