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Cellosaurus BICR 56 (CVCL_2313)

Cell line name BICR 56
Synonyms BICR-56; BICR56; Beatson Institute for Cancer Research 56
Accession CVCL_2313
Resource Identification Initiative To cite this cell line use: BICR 56 (RRID:CVCL_2313)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Omics: Deep RNAseq analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Sequence variations TP53 p.Tyr126_Asn131del (c.376_393del18) (PubMed=8390283).
Disease Tongue squamous cell carcinoma (NCIt: C4648)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling Age unspecified
Category Cancer cell line
STR profile Source(s): ECACC

Markers:
AmelogeninX
CSF1PO12
D13S31712
D16S53911
D5S81811,12
D7S8208,12
TH019,9.3
TPOX8,9
vWA15,16
Publications

PubMed=8390283; DOI=10.1038/bjc.1993.238
Burns J.E., Baird M.C., Clark L.J., Burns P.A., Edington K., Chapman C., Mitchell R., Robertson G., Soutar D., Parkinson E.K.
Gene mutations and increased levels of p53 protein in human squamous cell carcinomas and their cell lines.
Br. J. Cancer 67:1274-1284(1993)

PubMed=7646764; DOI=10.1002/mc.2940130408
Edington K.G., Loughran O.P., Berry I.J., Parkinson E.K.
Cellular immortality: a late event in the progression of human squamous cell carcinoma of the head and neck associated with p53 alteration and a high frequency of allele loss.
Mol. Carcinog. 13:254-265(1995)

PubMed=9150362; DOI=10.1038/sj.onc.1201028
Loughran O., Clark L.J., Bond J., Baker A., Berry I.J., Edington K.G., Ly I.-S., Simmons R., Haw R., Black D.M., Newbold R.F., Parkinson E.K.
Evidence for the inactivation of multiple replicative lifespan genes in immortal human squamous cell carcinoma keratinocytes.
Oncogene 14:1955-1964(1997)

PubMed=9307265
McGregor F., Wagner E., Felix D., Soutar D., Parkinson K., Harrison P.R.
Inappropriate retinoic acid receptor-beta expression in oral dysplasias: correlation with acquisition of the immortal phenotype.
Cancer Res. 57:3886-3889(1997)

PubMed=10523844; DOI=10.1038/sj.onc.1202957
Agochiya M., Brunton V.G., Owens D.W., Parkinson E.K., Paraskeva C., Keith W.N., Frame M.C.
Increased dosage and amplification of the focal adhesion kinase gene in human cancer cells.
Oncogene 18:5646-5653(1999)

PubMed=22460905; DOI=10.1038/nature11003
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.K., Yu J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L., Winckler W., Reich M., Li N., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

Cross-references
Cell line collections ECACC; 06031002
Ximbio; 152847
Cell line databases/resources CCLE; BICR56_UPPER_AERODIGESTIVE_TRACT
Gene expression databases ArrayExpress; E-MTAB-2770
GEO; GSM886887
GEO; GSM887952
Other Wikidata; Q54796532