ID   COR-L24
AC   CVCL_2409
SY   COR L24; Cor L24; CORL24
DR   CLO; CLO_0002588
DR   CLDB; cl879
DR   ArrayExpress; E-MTAB-2770
DR   BioSample; SAMN10988002
DR   cancercelllines; CVCL_2409
DR   Cell_Model_Passport; SIDM01490
DR   DepMap; ACH-000382
DR   ECACC; 96020717
DR   GEO; GSM886957
DR   GEO; GSM888025
DR   IARC_TP53; 28322
DR   LiGeA; CCLE_722
DR   PharmacoDB; CORL24_242_2019
DR   Progenetix; CVCL_2409
DR   Wikidata; Q54814275
RX   PubMed=2998422;
RX   PubMed=3034934;
RX   PubMed=8383976;
RX   PubMed=12397641;
RX   PubMed=22460905;
RX   PubMed=30894373;
RX   PubMed=31068700;
CC   Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
CC   Population: Caucasian.
CC   Sequence variation: Mutation; HGNC; 583; APC; Simple; p.Glu1554Ter (c.4660G>T); ClinVar=VCV000433664; Zygosity=Homozygous (DepMap).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Tyr234Cys (c.701A>G); ClinVar=VCV000127820; Zygosity=Heterozygous (DepMap).
CC   Omics: Deep exome analysis.
CC   Omics: SNP array analysis.
CC   Omics: Transcriptome analysis by microarray.
CC   Omics: Transcriptome analysis by RNAseq.
CC   Genome ancestry: African=3.16%; Native American=0%; East Asian, North=4.31%; East Asian, South=0%; South Asian=0%; European, North=57.22%; European, South=35.31% (PubMed=30894373).
CC   Derived from site: Metastatic; Lymph node; UBERON=UBERON_0000027.
ST   Source(s): ECACC
ST   Amelogenin: X
ST   CSF1PO: 11
ST   D13S317: 12
ST   D16S539: 12
ST   D5S818: 11
ST   D7S820: 11
ST   TH01: 7,9.3
ST   TPOX: 8
ST   vWA: 16,17
DI   NCIt; C4917; Lung small cell carcinoma
DI   ORDO; Orphanet_70573; Small cell lung cancer
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
OI   CVCL_D744 ! COR-L103
SX   Male
AG   71Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 05-10-23; Version: 26
//
RX   PubMed=2998422; DOI=10.1038/bjc.1985.220;
RA   Baillie-Johnson H., Twentyman P.R., Fox N.E., Walls G.A., Workman P.,
RA   Watson J.V., Johnson N., Reeve J.G., Bleehen N.M.;
RT   "Establishment and characterisation of cell lines from patients with
RT   lung cancer (predominantly small cell carcinoma).";
RL   Br. J. Cancer 52:495-504(1985).
//
RX   PubMed=3034934; DOI=10.1002/jcb.240330405;
RA   Ibson J.M., Waters J.J., Twentyman P.R., Bleehen N.M., Rabbitts P.H.;
RT   "Oncogene amplification and chromosomal abnormalities in small cell
RT   lung cancer.";
RL   J. Cell. Biochem. 33:267-288(1987).
//
RX   PubMed=8383976; DOI=10.1677/jme.0.0100025;
RA   Farrell W.E., Stewart M.F., Clark A.J.L., Crosby S.R., Davis J.R.E.,
RA   White A.;
RT   "Glucocorticoid inhibition of ACTH peptides: small cell lung cancer
RT   cell lines are more resistant than pituitary corticotroph adenoma
RT   cells.";
RL   J. Mol. Endocrinol. 10:25-32(1993).
//
RX   PubMed=12397641; DOI=10.1002/ijc.10704;
RA   Ashman J.N., Brigham J., Cowen M.E., Bahia H., Greenman J., Lind M.,
RA   Cawkwell L.;
RT   "Chromosomal alterations in small cell lung cancer revealed by
RT   multicolour fluorescence in situ hybridization.";
RL   Int. J. Cancer 102:230-236(2002).
//
RX   PubMed=22460905; DOI=10.1038/nature11003;
RA   Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A.,
RA   Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A.,
RA   Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J.,
RA   Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E.,
RA   Raman P., Shipway A., Engels I.H., Cheng J., Yu G.-Y.K., Yu J.-J.,
RA   Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C.,
RA   Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C.,
RA   Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N.-X., Mesirov J.P.,
RA   Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L.,
RA   Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M.L., Golub T.R.,
RA   Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.;
RT   "The Cancer Cell Line Encyclopedia enables predictive modelling of
RT   anticancer drug sensitivity.";
RL   Nature 483:603-607(2012).
//
RX   PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747;
RA   Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.;
RT   "An interactive resource to probe genetic diversity and estimated
RT   ancestry in cancer cell lines.";
RL   Cancer Res. 79:1263-1273(2019).
//
RX   PubMed=31068700; DOI=10.1038/s41586-019-1186-3;
RA   Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C.,
RA   McDonald E.R. III, Barretina J.G., Gelfand E.T., Bielski C.M., Li H.-X.,
RA   Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F.,
RA   Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R.,
RA   Lu Y.-L., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C.,
RA   Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A.,
RA   Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D.,
RA   Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L.,
RA   Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A.,
RA   Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D.,
RA   Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M.,
RA   Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R.,
RA   Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A.,
RA   Sellers W.R.;
RT   "Next-generation characterization of the Cancer Cell Line
RT   Encyclopedia.";
RL   Nature 569:503-508(2019).
//