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Cellosaurus COV362.4 (CVCL_2421)

[Text version]
Cell line name COV362.4
Synonyms COV362-4; COV-362.4
Accession CVCL_2421
Resource Identification Initiative To cite this cell line use: COV362.4 (RRID:CVCL_2421)
Comments Part of: OCCP ovarian cancer cell line panel.
Population: Caucasian.
Omics: Transcriptome analysis by microarray.
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Mutation; HGNC; 1100; BRCA1; Simple; p.Pro871fs (c.2611_2612ins1); Zygosity=Homozygous (PubMed=25230021).
  • Mutation; HGNC; 1100; BRCA1; Simple; c.4095+1G>T; Zygosity=Homozygous; Note=Splice donor mutation (PubMed=25230021).
  • Mutation; HGNC; 11998; TP53; Simple; p.Tyr220Cys (c.659A>G); ClinVar=VCV000127819; Zygosity=Homozygous (PubMed=25230021).
Disease High grade ovarian serous adenocarcinoma (NCIt: C105555)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_2420 (COV362)
Sex of cell Female
Age at sampling Age unspecified
Category Cancer cell line
STR profile Source(s): ECACC; PubMed=25230021; PubMed=25877200

Markers:
AmelogeninX
CSF1PO11,12
D2S133824,25
D3S135816,18
D5S81812,13 (PubMed=25877200)
13 (PubMed=25230021)
D7S82010,14
D8S117911
D13S31714
D16S53911
D18S5113
D19S43314
D21S1131,32.2
FGA24
Penta D9,11
Penta E7,11
TH019.3
TPOX11
vWA15,18

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Publications

PubMed=8436435; DOI=10.1002/ijc.2910530415
van den Berg-Bakker C.A.M., Hagemeijer A., Franken-Postma E.M., Smit V.T.H.B.M., Kuppen P.J.K., van Ravenswaay Claasen H.H., Cornelisse C.J., Schrier P.I.
Establishment and characterization of 7 ovarian carcinoma cell lines and one granulosa tumor cell line: growth features and cytogenetics.
Int. J. Cancer 53:613-620(1993)

PubMed=25230021; DOI=10.1371/journal.pone.0103988
Beaufort C.M., Helmijr J.C.A., Piskorz A.M., Hoogstraat M., Ruigrok-Ritstier K., Besselink N., Murtaza M., van IJcken W.F.J., Heine A.A.J., Smid M., Koudijs M.J., Brenton J.D., Berns E.M.J.J., Helleman J.
Ovarian cancer cell line panel (OCCP): clinical importance of in vitro morphological subtypes.
PLoS ONE 9:E103988-E103988(2014)

PubMed=25877200; DOI=10.1038/nature14397
Yu M., Selvaraj S.K., Liang-Chu M.M.Y., Aghajani S., Busse M., Yuan J., Lee G., Peale F.V., Klijn C., Bourgon R., Kaminker J.S., Neve R.M.
A resource for cell line authentication, annotation and quality control.
Nature 520:307-311(2015)

Cross-references
Cell line collections (Providers) ECACC; 07071904
Cell line databases/resources cancercelllines; CVCL_2421
Cell_Model_Passport; SIDM01630
Biological sample resources BioSample; SAMN03473272
Encyclopedic resources Wikidata; Q54814343
Gene expression databases GEO; GSM313709
GEO; GSM1291134
Polymorphism and mutation databases Progenetix; CVCL_2421
Entry history
Entry creation04-Apr-2012
Last entry update05-Oct-2023
Version number22