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Cellosaurus FTC-236 (CVCL_2446)

[Text version]
Cell line name FTC-236
Synonyms FTC236
Accession CVCL_2446
Resource Identification Initiative To cite this cell line use: FTC-236 (RRID:CVCL_2446)
Comments Population: Caucasian.
Characteristics: Has a near-homozygous genome (NHG) (PubMed=29066502).
Omics: Mitochondrial genome sequenced.
Omics: Transcriptome analysis by microarray.
Misspelling: CFT-236; PubMed=1384245; Note=In the French and Spanish abstracts where the abbreviation 'FTC' was translated to 'CFT' and thus also the cell line names.
Derived from site: Metastatic; Cervical lymph node; UBERON=UBERON_0002429.
Sequence variations
  • Mutation; HGNC; 7329; MSH6; Simple; p.Lys1045fs (c.3135delG); Zygosity=Homozygous (PubMed=30737244).
  • Mutation; HGNC; 9588; PTEN; Simple; p.Arg130Ter (c.388C>T); ClinVar=VCV000007819; Zygosity=Homozygous (PubMed=30737244).
  • Mutation; HGNC; 9884; RB1; Simple; p.Arg320Ter (c.958C>T); ClinVar=VCV000126824; Zygosity=Homozygous (PubMed=30737244).
  • Mutation; HGNC; 11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Homozygous; Note=In promoter (PubMed=30737244).
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg273His (c.818G>A); ClinVar=VCV000012366; Zygosity=Homozygous (PubMed=30737244).
Disease Thyroid gland follicular carcinoma (NCIt: C8054)
Differentiated thyroid carcinoma (ORDO: Orphanet_146)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_1219 ! FTC-133
CVCL_2447 ! FTC-238
Sex of cell Male
Age at sampling 42Y
Category Cancer cell line
STR profile Source(s): ECACC; PubMed=30737244

Markers:
AmelogeninX
CSF1PO10,11
D3S135815,16
D5S81811,12
D7S8209,10
D8S117910
D13S31711
D16S53911,12
D18S5111,12
D21S1132.2
FGA21
TH019.3
TPOX9
vWA15,18

Run an STR similarity search on this cell line
Publications

PubMed=1384245; DOI=10.1007/BF02067383
Demeure M.J., Damsky C.H., Elfman F., Goretzki P.E., Wong M.G., Clark O.H.
Invasion by cultured human follicular thyroid cancer correlates with increased beta 1 integrins and production of proteases.
World J. Surg. 16:770-776(1992)

PubMed=29066502; DOI=10.1530/ERC-17-0288
Corver W.E., Demmers J., Oosting J., Sahraeian S., Boot A., Ruano D., van Wezel T., Morreau H.
ROS-induced near-homozygous genomes in thyroid cancer.
Endocr. Relat. Cancer 25:83-97(2018)

PubMed=30737244; DOI=10.1158/1078-0432.CCR-18-2953
Landa I., Pozdeyev N., Korch C.T., Marlow L.A., Smallridge R.C., Copland J.A. III, Henderson Y.C., Lai S.Y., Clayman G.L., Onoda N., Tan A.-C., Garcia-Rendueles M.E.R., Knauf J.A., Haugen B.R., Fagin J.A., Schweppe R.E.
Comprehensive genetic characterization of human thyroid cancer cell lines: a validated panel for preclinical studies.
Clin. Cancer Res. 25:3141-3151(2019)

PubMed=31443247; DOI=10.3390/cancers11081185
Aydemirli M.D., Corver W.E., Beuk R., Roepman P., Solleveld-Westerink N., van Wezel T., Kapiteijn E.H.W., Morreau H.
Targeted treatment options of recurrent radioactive iodine refractory Hurthle cell cancer.
Cancers (Basel) 11:1185.1-1185.16(2019)

Cross-references
Cell line collections (Providers) ECACC; 06030202
Cell line databases/resources cancercelllines; CVCL_2446
Cell_Model_Passport; SIDM00229
Anatomy/cell type resources BTO; BTO:0003875
Encyclopedic resources Wikidata; Q54835218
Polymorphism and mutation databases Cosmic; 1239977
Entry history
Entry creation04-Apr-2012
Last entry update05-Oct-2023
Version number19