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Cellosaurus FTC-238 (CVCL_2447)

[Text version]

Cell line name FTC-238
Synonyms FTC238
Accession CVCL_2447
Resource Identification Initiative To cite this cell line use: FTC-238 (RRID:CVCL_2447)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Characteristics: Highly invasive.
Microsatellite instability: Instable (MSI) (PubMed=31068700).
Omics: Deep exome analysis.
Omics: Deep RNAseq analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Misspelling: CFT-238; In PubMed=1384245 in the French and Spanish abstracts where the abbreviation 'FTC' was translated to 'CFT' and thus also the cell line names.
Sequence variations Homozygous for MSH6 p.Lys1045fs (c.3135delG) (PubMed=30737244).
Homozygous for PTEN p.Arg130Ter (c.388C>T) (PubMed=30737244).
Homozygous for RB1 p.Arg320Ter (c.958C>T) (PubMed=30737244; CCLE).
Homozygous for TERT c.228C>T (-124C>T); in promoter (PubMed=30737244).
Homozygous for TP53 p.Arg273His (c.818G>A) PubMed=14522906; PubMed=30737244).
Genome ancestry Source: PubMed=30894373

Origin% genome
African1.72
Native American2.05
East Asian, North2
East Asian, South0
South Asian0
European, North60.8
European, South33.42
Disease Thyroid gland follicular carcinoma (NCIt: C8054)
Derived from metastatic site: Lung.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_1219 ! FTC-133
CVCL_2446 ! FTC-236
Sex of cell Male
Age at sampling 42Y
Category Cancer cell line
STR profile Source(s): ECACC; PubMed=25877200; PubMed=30737244

Markers:
AmelogeninX
CSF1PO10,11
D2S133820
D3S135816
D5S81811,12
D7S8209,10
D8S117910
D13S31711
D16S53911,12
D18S5111,12
D19S43313
D21S1132.2
FGA21
Penta D12
Penta E13
TH019.3
TPOX9
vWA15,18

Run an STR similarity search on this cell line
Publications

PubMed=1384245; DOI=10.1007/BF02067383
Demeure M.J., Damsky C.H., Elfman F., Goretzki P.E., Wong M.G., Clark O.H.
Invasion by cultured human follicular thyroid cancer correlates with increased beta 1 integrins and production of proteases.
World J. Surg. 16:770-776(1992)

PubMed=14522906
Frasca F., Vella V., Aloisi A., Mandarino A., Mazzon E., Vigneri R., Vigneri P.
p73 tumor-suppressor activity is impaired in human thyroid cancer.
Cancer Res. 63:5829-5837(2003)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458
Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A.
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=30737244; DOI=10.1158/1078-0432.CCR-18-2953
Landa I., Pozdeyev N., Korch C., Marlow L.A., Smallridge R.C., Copland J.A., Henderson Y.C., Lai S.Y., Clayman G.L., Onoda N., Tan A.C., Garcia-Rendueles M.E.R., Knauf J.A., Haugen B.R., Fagin J.A., Schweppe R.E.
Comprehensive genetic characterization of human thyroid cancer cell lines: a validated panel for preclinical studies.
Clin. Cancer Res. 25:3141-3151(2019)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z., Monteiro A.N., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3
Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. III, Barretina J., Gelfand E.T., Bielski C.M., Li H., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R.
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

Cross-references
Cell line collections AddexBio; C0025001/38
ECACC; 94060902
ICLC; HTL96003
Cell line databases/resources CLDB; cl1400
CLDB; cl1401
CCLE; FTC238_THYROID
Cell_Model_Passport; SIDM00228
DepMap; ACH-000897
LINCS_LDP; LCL-1678
TOKU-E; 4078
Ontologies CLO; CLO_0003403
Biological sample resources BioSample; SAMN03470981
BioSample; SAMN10987981
Chemistry resources PharmacoDB; FTC238_369_2019
Gene expression databases ArrayExpress; E-MTAB-2770
GEO; GSM827316
Other Wikidata; Q54835219
Polymorphism and mutation databases Cosmic; 1239978
IARC_TP53; 27013
LiGeA; CCLE_558
Entry history
Entry creation04-Apr-2012
Last entry updated06-Sep-2019
Version number22