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Cellosaurus GR-M (CVCL_2451)

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Cell line name GR-M
Synonyms GRM
Accession CVCL_2451
Resource Identification Initiative To cite this cell line use: GR-M (RRID:CVCL_2451)
Comments Problematic cell line: Contaminated. Shown to be a PSN1 derivative (PubMed=25877200). Originally thought to originate from the thorax of a 36 year old male melanoma patient with skin metastases.
Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00538.
Omics: Deep exome analysis.
Omics: Deep RNAseq analysis.
Omics: SNP array analysis.
Sequence variations Homozygous for CDKN2A deletion (from parent cell line).
Heterozygous for KRAS p.Gly12Arg (c.34G>C) (CCLE).
Homozygous for SMAD4 deletion (from parent cell line).
TP53 p.Lys132Gln (c.394A>C) (CCLE).
HLA typing Source: PubMed=15592718
Class I
HLA-AA*24:02,24:02
HLA-BB*52:01:01,52:01:01
HLA-CC*12:02,12:02
Class II
HLA-DPDPB1*09:01
HLA-DQDQB1*06:02,06:01:01
HLA-DRDRB1*15:01
Genome ancestry Source: PubMed=30894373

Origin% genome
African0
Native American0
East Asian, North83.55
East Asian, South15.04
South Asian1.41
European, North0
European, South0
Disease Pancreatic adenocarcinoma (NCIt: C8294)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1644 (PSN1)
Sex of cell Male
Age at sampling Age unspecified
Category Cancer cell line
STR profile Source(s): PubMed=25877200

Markers:
AmelogeninX
CSF1PO12
D3S135815
D5S81811,13
D7S82010
D8S117910,14
D13S31710
D16S53910,11
D18S5121
D21S1129,30
FGA23
Penta D9,12
Penta E14,15
TH016
TPOX8,11
vWA17

Run an STR similarity search on this cell line
Web pages http://iclac.org/wp-content/uploads/Cross-Contaminations_v9_distribution.xlsx
Publications

PubMed=7780963
Easty D.J., Guthrie B.A., Maung K., Farr C.J., Lindberg R.A., Toso R.J., Herlyn M., Bennett D.C.
Protein B61 as a new growth factor: expression of B61 and up-regulation of its receptor epithelial cell kinase during melanoma progression.
Cancer Res. 55:2528-2532(1995)

PubMed=15592718; DOI=10.1007/s00262-004-0561-5
Rodriguez T., Mendez R., Roberts C.H., Ruiz-Cabello F., Dodi I.A., Lopez Nevot M.A., Paco L., Maleno I., Marsh S.G.E., Pawelec G., Garrido F.
High frequency of homozygosity of the HLA region in melanoma cell lines reveals a pattern compatible with extensive loss of heterozygosity.
Cancer Immunol. Immunother. 54:141-148(2005)

PubMed=25485619; DOI=10.1038/nbt.3080
Klijn C., Durinck S., Stawiski E.W., Haverty P.M., Jiang Z., Liu H., Degenhardt J., Mayba O., Gnad F., Liu J., Pau G., Reeder J., Cao Y., Mukhyala K., Selvaraj S.K., Yu M., Zynda G.J., Brauer M.J., Wu T.D., Gentleman R.C., Manning G., Yauch R.L., Bourgon R., Stokoe D., Modrusan Z., Neve R.M., de Sauvage F.J., Settleman J., Seshagiri S., Zhang Z.
A comprehensive transcriptional portrait of human cancer cell lines.
Nat. Biotechnol. 33:306-312(2015)

PubMed=25877200; DOI=10.1038/nature14397
Yu M., Selvaraj S.K., Liang-Chu M.M.Y., Aghajani S., Busse M., Yuan J., Lee G., Peale F., Klijn C., Bourgon R., Kaminker J.S., Neve R.M.
A resource for cell line authentication, annotation and quality control.
Nature 520:307-311(2015)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z., Monteiro A.N., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3
Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. III, Barretina J., Gelfand E.T., Bielski C.M., Li H., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R.
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

Cross-references
Cell line collections ECACC; 95032301
Cell line databases/resources CLDB; cl1513
CCLE; GRM_SKIN
Cell_Model_Passport; SIDM00468
DepMap; ACH-001072
ESTDAB; ESTDAB-036 - Discontinued
Ontologies CLO; CLO_0003564
EFO; EFO_0006577
Biological sample resources BioSample; SAMN03472907
BioSample; SAMN10988055
Chemistry resources PharmacoDB; GRM_412_2019
Gene expression databases ArrayExpress; E-MTAB-2706
Other Wikidata; Q54871656
Polymorphism and mutation databases Cosmic; 2163785
IARC_TP53; 21349
Entry history
Entry creation04-Apr-2012
Last entry updated06-Sep-2019
Version number19