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Cellosaurus H157 (CVCL_2458)

[Text version]
Cell line name H157
Accession CVCL_2458
Resource Identification Initiative To cite this cell line use: H157 (RRID:CVCL_2458)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Derived from site: In situ; Oral cavity, buccal mucosa; UBERON=UBERON_0006956.
Sequence variations
  • Mutation; HGNC; 1787; CDKN2A; Simple; p.Arg80Ter (c.237_238CC>TT) (c.237_238delinsTT) (p.Pro94Leu, c.280_281CC>TT); Zygosity=Homozygous (DepMap).
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg306Ter (c.916C>T); ClinVar=VCV000142144; Zygosity=Homozygous (PubMed=7633286; DepMap).
Disease Buccal mucosa squamous cell carcinoma (NCIt: C4040)
Squamous cell carcinoma of the oral cavity (ORDO: Orphanet_502363)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 84Y
Category Cancer cell line
STR profile Source(s): CCRID; DepMap; ECACC

Markers:
AmelogeninX,Y
CSF1PO10
D3S135815,18
D5S81810,11
D7S8209
D8S117913,15
D13S3178,12
D16S53911
D18S5120,22
D21S1128,29
FGA19,20
Penta D12
Penta E7,11
TH019.3
TPOX8
vWA16

Run an STR similarity search on this cell line
Publications

PubMed=1692339; DOI=10.1002/path.1711600313
Prime S.S., Nixon S.V.R., Crane I.J., Stone A., Matthews J.B., Maitland N.J., Remnant L., Powell S.K., Game S.M., Scully C.
The behaviour of human oral squamous cell carcinoma in cell culture.
J. Pathol. 160:259-269(1990)

PubMed=1744799; DOI=10.1002/path.1711650208
Mutlu S., Matthews J.B., Midda M., Scully C., Prime S.S.
MHC antigen expression in human oral squamous carcinoma cell lines.
J. Pathol. 165:129-136(1991)

PubMed=7633286; DOI=10.1016/0964-1955(94)00030-8
Yeudall W.A., Paterson I.C., Patel V., Prime S.S.
Presence of human papillomavirus sequences in tumour-derived human oral keratinocytes expressing mutant p53.
Eur. J. Cancer B Oral Oncol. 31:136-143(1995)

Cross-references
Cell line collections (Providers) CancerTools; 153420
ECACC; 07030901
KCB; KCB 2015028YJ
Ximbio; 153420
Cell line databases/resources cancercelllines; CVCL_2458
CCRID; 5301HUM-KCB15028YJ
Cell_Model_Passport; SIDM01808
DepMap; ACH-001347
Encyclopedic resources Wikidata; Q54871942
Polymorphism and mutation databases Cosmic; 716674
Cosmic; 916368
Cosmic; 928235
Entry history
Entry creation04-Apr-2012
Last entry update05-Oct-2023
Version number21