ID   H69V
AC   CVCL_2466
AS   CVCL_S829
SY   H69v; MOG-H69V
DR   CLO; CLO_0003611
DR   CLDB; cl1554
DR   cancercelllines; CVCL_2466
DR   ECACC; 91091803
DR   GEO; GSM827449
DR   LINCS_LDP; LCL-1875
DR   Progenetix; CVCL_2466
DR   Wikidata; Q54872208
RX   PubMed=1662924;
RX   PubMed=8712684;
RX   PubMed=20215515;
CC   Population: Caucasian.
CC   Doubling time: 34.0 hours (PubMed=1662924).
CC   Sequence variation: Mutation; HGNC; 8975; PIK3CA; Simple; p.Gly106_Arg108del (c.317_325delGGCAACCGT); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 9884; RB1; Simple; p.Glu748Ter (c.2242G>T); ClinVar=VCV000013078; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Glu171Ter (c.511G>T); ClinVar=VCV000634771; Zygosity=Homozygous (from parent cell line).
CC   Omics: SNP array analysis.
CC   Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
ST   Source(s): ECACC
ST   Amelogenin: X,Y
ST   CSF1PO: 10,12
ST   D13S317: 12
ST   D16S539: 11
ST   D5S818: 11,13
ST   D7S820: 9
ST   TH01: 8,9
ST   TPOX: 10
ST   vWA: 16,17
DI   NCIt; C4917; Lung small cell carcinoma
DI   ORDO; Orphanet_70573; Small cell lung cancer
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_1579 ! NCI-H69
SX   Male
AG   55Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 05-10-23; Version: 24
//
RX   PubMed=1662924;
RA   Khan M.Z., Freshney R.I., Murray A.M.B., Merry S., Plumb J.A.,
RA   McNicol A.M.;
RT   "Identification and characterisation in vitro of cells with a non-SCLC
RT   cell-like phenotype derived from a continuous SCLC cell line.";
RL   Anticancer Res. 11:1687-1695(1991).
//
RX   PubMed=8712684;
RA   Khan M.Z., McNicol A.M., Freshney R.I.;
RT   "Tumorigenicity, invasion and metastasis of the small cell lung cancer
RT   cell line NCI-H69 and two derivative lines MOG-H69V and MOG-H69VZ.";
RL   Anticancer Res. 16:1659-1669(1996).
//
RX   PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458;
RA   Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P.,
RA   Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J.,
RA   Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C.,
RA   Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J.,
RA   Haber D.A.;
RT   "A genome-wide screen for microdeletions reveals disruption of
RT   polarity complex genes in diverse human cancers.";
RL   Cancer Res. 70:2158-2164(2010).
//