Home  |  Contact

Cellosaurus HEL 92.1.7 (CVCL_2481)

[Text version]

Cell line name HEL 92.1.7
Synonyms HEL92.1.7; HEL-92.1.7; HEL-92-1-7; HEL-92_1_7; HEL-92; HEL9217
Accession CVCL_2481
Resource Identification Initiative To cite this cell line use: HEL 92.1.7 (RRID:CVCL_2481)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Part of: Tumor Immunology Bank (TIB) collection from Salk (transferred to ATCC in 1981).
Omics: Deep exome analysis.
Omics: Deep RNAseq analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Miscellaneous: Originally the patient was suffering from Hodgkin lymphoma.
Derived from sampling site: Peripheral blood.
Sequence variations Homozygous for JAK2 p.Val617Phe (c.1849G>T) (from parent cell line).
Homozygous for TP53 p.Met133Lys (c.398T>A) (CCLE).
HLA typing Source: CLS
Class I
HLA-AA*03,w32
HLA-BB*w35
Genome ancestry Source: PubMed=30894373

Origin% genome
African0
Native American2.04
East Asian, North1.78
East Asian, South0.21
South Asian6.68
European, North17.09
European, South72.21
Disease Erythroleukemia (NCIt: C7152)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0001 (HEL)
Children:
CVCL_4Z61 (HEL/TGR)
Sex of cell Male
Age at sampling 30Y
Category Cancer cell line
STR profile Source(s): ATCC; CLS; ECACC

Markers:
AmelogeninX,Y
CSF1PO10
D3S135815
D5S81811
D7S8207
D8S117913,15
D13S3179,11
D16S53911
D18S5112,16
D21S1129,30.2
FGA22,23
Penta D11,13
Penta E13,18
TH017
TPOX11
vWA14,17

Run an STR similarity search on this cell line
Publications

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458
Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A.
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=22460905; DOI=10.1038/nature11003
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.K., Yu J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=30285677; DOI=10.1186/s12885-018-4840-5
Tan K.-T., Ding L.-W., Sun Q.-Y., Lao Z.-T., Chien W., Ren X., Xiao J.-F., Loh X.-Y., Xu L., Lill M., Mayakonda A., Lin D.-C., Yang H., Koeffler H.P.
Profiling the B/T cell receptor repertoire of lymphocyte derived cell lines.
BMC Cancer 18:940-940(2018)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z., Monteiro A.N., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3
Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. III, Barretina J., Gelfand E.T., Bielski C.M., Li H., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R.
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

Cross-references
Cell line collections ATCC; TIB-180
BCRC; 60370
BCRJ; 0308
CLS; 300462/p465_HEL_9217
ECACC; 92111706
ICLC; HTL03002
Cell line databases/resources CLDB; cl5067
CLDB; cl7132
CCLE; HEL9217_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE
Cell_Model_Passport; SIDM00593
DepMap; ACH-000005
IGRhCellID; HEL9217
LINCS_LDP; LCL-1076
Lonza; 1042
Ontologies BTO; BTO:0003320
CLO; CLO_0003682
CLO; CLO_0003683
EFO; EFO_0002193
Biological sample resources BioSample; SAMN10987842
Chemistry resources PharmacoDB; HEL92.1.7_535_2019
Gene expression databases ArrayExpress; E-MTAB-2770
GEO; GSM887076
GEO; GSM888146
GEO; GSM1374526
GEO; GSM1374527
Other Wikidata; Q54882504
Polymorphism and mutation databases Cosmic; 683543
Cosmic; 976723
IARC_TP53; 21369
LiGeA; CCLE_672
Entry history
Entry creation04-Apr-2012
Last entry updated06-Sep-2019
Version number23