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Cellosaurus HRT-18 (CVCL_2514)

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Cell line name HRT-18
Synonyms HRT18
Accession CVCL_2514
Resource Identification Initiative To cite this cell line use: HRT-18 (RRID:CVCL_2514)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Microsatellite instability: Instable (MSI) (PubMed=31068700).
Omics: Deep exome analysis.
Omics: SNP array analysis.
Sequence variations Heterozygous for KRAS p.Gly13Asp (c.38G>A) (PubMed=12068308; CCLE).
Heterozygous for PIK3CA p.Glu545Lys (c.1633G>A) (CCLE).
Genome ancestry Source: PubMed=30894373

Origin% genome
African0
Native American0.15
East Asian, North0.34
East Asian, South1.05
South Asian1.84
European, North63.7
European, South32.91
Disease Colon adenocarcinoma (NCIt: C4349)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_3449 (__Parent_cell_line_of_DLD-1/HCT 8/HCT 15/HRT-18)
Children:
CVCL_2515 (HRT-18G)
Sex of cell Male
Age at sampling 67Y
Category Cancer cell line
STR profile Source(s): ATCC; CLS; ECACC

Markers:
AmelogeninX,Y
CSF1PO12
D3S135817
D5S81813
D7S82010,11.3,12 (ATCC)
10,12 (CLS; ECACC)
D8S117915
D13S3178,11
D16S53912,13
D18S5111,17
D21S1129,32.2
FGA22
Penta D9,14
Penta E7,14
TH017,9.3
TPOX8,11
vWA18,19

Run an STR similarity search on this cell line
Publications

PubMed=3349466
Chantret I., Barbat A., Dussaulx E., Brattain M.G., Zweibaum A.
Epithelial polarity, villin expression, and enterocytic differentiation of cultured human colon carcinoma cells: a survey of twenty cell lines.
Cancer Res. 48:1936-1942(1988)

PubMed=9809040; DOI=10.1016/S0165-4608(98)00081-8
Vermeulen S.J., Chen T.-R., Speleman F., Nollet F., van Roy F.M., Mareel M.M.
Did the four human cancer cell lines DLD-1, HCT-15, HCT-8, and HRT-18 originate from one and the same patient?
Cancer Genet. Cytogenet. 107:76-79(1998)

PubMed=12068308; DOI=10.1038/nature00766
Davies H., Bignell G.R., Cox C., Stephens P., Edkins S., Clegg S., Teague J.W., Woffendin H., Garnett M.J., Bottomley W., Davis N., Dicks E., Ewing R., Floyd Y., Gray K., Hall S., Hawes R., Hughes J., Kosmidou V., Menzies A., Mould C., Parker A., Stevens C., Watt S., Hooper S., Wilson R., Jayatilake H., Gusterson B.A., Cooper C., Shipley J.M., Hargrave D., Pritchard-Jones K., Maitland N.J., Chenevix-Trench G., Riggins G.J., Bigner D.D., Palmieri G., Cossu A., Flanagan A.M., Nicholson A., Ho J.W.C., Leung S.Y., Yuen S.T., Weber B.L., Seigler H.F., Darrow T.L., Paterson H., Marais R., Marshall C.J., Wooster R., Stratton M.R., Futreal P.A.
Mutations of the BRAF gene in human cancer.
Nature 417:949-954(2002)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458
Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A.
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z., Monteiro A.N., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3
Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. III, Barretina J., Gelfand E.T., Bielski C.M., Li H., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R.
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

Cross-references
Cell line collections ATCC; CCL-244
BCRC; 60303
BCRJ; 0106
CCLV; CCLV-RIE 0108
CLS; 300210/p475_HCT-8_(HRT-18)
ECACC; 86040306
IZSLER; BS TCL 26
Cell line databases/resources CLDB; cl1710
CLDB; cl1711
CCLE; HRT18_LARGE_INTESTINE
Cell_Model_Passport; SIDM00788
ColonAtlas; HRT18
DepMap; ACH-001091
LINCS_LDP; LCL-1289
Ontologies BTO; BTO:0001947
CLO; CLO_0003668
CLO; CLO_0003836
Biological sample resources BioSample; SAMN03471480
BioSample; SAMN10989582
Chemistry resources ChEMBL-Cells; CHEMBL3308672
ChEMBL-Targets; CHEMBL614834
PharmacoDB; HRT18_567_2019
Gene expression databases GEO; GSM827431
Other Wikidata; Q54895337
Polymorphism and mutation databases Cosmic; 724841
Entry history
Entry creation04-Apr-2012
Last entry updated06-Sep-2019
Version number21