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Cellosaurus Ishikawa (CVCL_2529)

[Text version]

Cell line name Ishikawa
Synonyms ISHIKAWA; ISHI
Accession CVCL_2529
Resource Identification Initiative To cite this cell line use: Ishikawa (RRID:CVCL_2529)
Comments Part of: ENCODE project common cell types; tier 3.
Doubling time: 36 hours (at 9th passage), 29 hours (at 40th passage), 27 hours (at 50th passage) (DOI=10.1007/978-4-431-53981-0_2); 35.14 +- 2.68 hours (PubMed=23255909).
Omics: Array-based CGH.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Misspelling: Ischikawaa; Occasionally.
Sequence variations Heterozygous for PTEN p.Ser302fs*4 (c.906delC) and p.Thr319fs*1 (c.950_953delTACT) (V317fs*3) (PubMed=20944090).
Disease Endometrial adenocarcinoma (NCIt: C7359)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_W441 (EIIL)CVCL_N296 (IK-6)CVCL_9996 (IK-90)
CVCL_IR24 (ISH/DDP)CVCL_W420 (Ishikawa 1-A-12)CVCL_W421 (Ishikawa 1-A-9)
CVCL_W422 (Ishikawa 1-C-10)CVCL_W423 (Ishikawa 1-D-9)CVCL_W424 (Ishikawa 1-E-8)
CVCL_W425 (Ishikawa 1-F-6)CVCL_W426 (Ishikawa 1-H-6)CVCL_W427 (Ishikawa 2-B-12)
CVCL_W428 (Ishikawa 2-C-3)CVCL_W429 (Ishikawa 2-C-7)CVCL_W430 (Ishikawa 2-E-7)
CVCL_W431 (Ishikawa 2-F-4)CVCL_W432 (Ishikawa 3-D-7)CVCL_W433 (Ishikawa 3-D-9)
CVCL_D199 (Ishikawa 3-H-12)CVCL_W434 (Ishikawa 3-H-3)CVCL_W435 (Ishikawa 3-H-4)
CVCL_W436 (Ishikawa 3-H-7)CVCL_6543 (Ishikawa (Heraklio) 02 ER-)CVCL_8783 (Ishikawa (London) 02 ER+)
CVCL_IJ14 (Ishikawa-RP)
Sex of cell Female
Age at sampling 39Y
Category Cancer cell line
STR profile Source(s): ECACC; PubMed=25877200

Markers:
AmelogeninX
CSF1PO11,12
D2S133820
D3S135815,17
D5S81810,11
D7S8209,10
D8S117912,16
D13S3179,12
D16S5399
D18S5113,19
D19S43312.2,14
D21S1128
FGA21
Penta D10,11
Penta E11,19
TH019,10
TPOX8
vWA14,17
Web pages http://genome.ucsc.edu/ENCODE/protocols/cell/human/Ishikawa_Crawford_protocol.pdf
Publications

PubMed=4031568
Nishida M., Kasahara K., Kaneko M., Iwasaki H., Hayashi K.
Establishment of a new human endometrial adenocarcinoma cell line, Ishikawa cells, containing estrogen and progesterone receptors.
Nihon Sanka Fujinka Gakkai Zasshi 37:1103-1111(1985)

PubMed=12703541; DOI=10.1111/j.1749-0774.2002.tb00105.x
Nishida M.
The Ishikawa cells from birth to the present.
Hum. Cell 15:104-117(2002)

DOI=10.1007/978-4-431-53981-0_2
Nishida M.
Ishikawa cells: opening of in vitro hormone research on endometrial carcinoma.
(In) Cell and molecular biology of endometrial carcinoma; Kuramoto H., Nishida M. (eds.); pp.35-58; Springer; Tokyo (2003)

PubMed=15053063
Kamata Y., Watanabe J., Hata H., Hamano M., Kuramoto H.
Quantitative study on the correlation between p53 gene mutation and its expression in endometrial carcinoma cell lines.
Eur. J. Gynaecol. Oncol. 25:55-60(2004)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458
Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A.
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=20218740; DOI=10.1177/153303461000900207
Wang Y., Yang D., Cogdell D., Hu L., Xue F., Broaddus R., Zhang W.
Genomic characterization of gene copy-number aberrations in endometrial carcinoma cell lines derived from endometrioid-type endometrial adenocarcinoma.
Technol. Cancer Res. Treat. 9:179-189(2010)

PubMed=20944090; DOI=10.1126/scitranslmed.3001538
Dedes K.J., Wetterskog D., Mendes-Pereira A.M., Natrajan R., Lambros M.B., Geyer F.C., Vatcheva R., Savage K., Mackay A., Lord C.J., Ashworth A., Reis-Filho J.S.
PTEN deficiency in endometrioid endometrial adenocarcinomas predicts sensitivity to PARP inhibitors.
Sci. Transl. Med. 2:53ra75-53ra75(2010)

PubMed=22710073; DOI=10.1016/j.ygyno.2012.06.017
Korch C., Spillman M.A., Jackson T.A., Jacobsen B.M., Murphy S.K., Lessey B.A., Jordan V.C., Bradford A.P.
DNA profiling analysis of endometrial and ovarian cell lines reveals misidentification, redundancy and contamination.
Gynecol. Oncol. 127:241-248(2012)

PubMed=23255909; DOI=10.3892/ol.2012.975
Zhao S.-Z., Li G.-X., Yang L., Li L., Li H.-Y.
Response-specific progestin resistance in a newly characterized Ishikawa human endometrial cancer subcell line resulting from long-term exposure to medroxyprogesterone acetate.
Oncol. Lett. 5:139-144(2013)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

Cross-references
Cell line collections BCRJ; 0364
ECACC; 99040201
Cell line databases/resources Cell_Model_Passport; SIDM00038
LINCS_HMS; 50018
LINCS_LDP; LCL-1497
TOKU-E; 3966
Ontologies BTO; BTO:0003041
EFO; EFO_0005718
Biological sample resources BioSample; SAMN03471030
ENCODE; ENCBS228AAA
ENCODE; ENCBS229AAA
ENCODE; ENCBS230AAA
Chemistry resources ChEMBL-Cells; CHEMBL3307675
ChEMBL-Targets; CHEMBL614649
Gene expression databases ArrayExpress; E-MTAB-3610
GEO; GSM374972
GEO; GSM375431
GEO; GSM827370
GEO; GSM1008593
GEO; GSM1008594
GEO; GSM1669941
Other Wikidata; Q54898281
Polymorphism and mutation databases Cosmic; 713475
Cosmic; 713499
Cosmic; 809129
Cosmic; 846174
Cosmic; 1070811
Cosmic; 1152553
Cosmic; 1176597
Cosmic; 1177618
Cosmic; 1241344
Cosmic; 1622902
Cosmic; 1696753
Cosmic; 2030475
Cosmic; 2464666
Cosmic; 2646616