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Cellosaurus J45.01 (CVCL_2530)

[Text version]

Cell line name J45.01
Accession CVCL_2530
Resource Identification Initiative To cite this cell line use: J45.01 (RRID:CVCL_2530)
Comments Characteristics: CD45-deficient.
Derived from sampling site: Peripheral blood.
Sequence variations Heterozygous for BAX p.Glu41Argfs*19 (c.121delG) (ClinVar=VCV000009512) (from parent cell line).
Heterozygous for BAX p.Glu41Glyfs*33 (c.121dupG) (ClinVar=VCV000009511) (from parent cell line).
Heterozygous for FBXW7 p.Arg505Cys (c.1513C>T) (ClinVar=VCV000069961) (from parent cell line).
Heterozygous for INPP5D p.Gln345Ter (c.1033C>T) (from parent cell line).
Heterozygous for INPP5D c.1097+1065_1097+1112del47 (from parent cell line).
Homozygous for MSH2 p.Arg711Ter (c.2131C>T) (ClinVar=VCV000090903) (from parent cell line).
Homozygous for MSH6 p.Phe1088Serfs*2 (c.3261delC) (ClinVar=VCV000089363) (from parent cell line).
Heterozygous for SYK p.Met34Hisfs*3 (c.98_99insG) (from parent cell line).
Heterozygous for TP53 p.Arg196Ter (c.586C>T) (ClinVar=VCV000043589) (from parent cell line).
Disease Childhood T acute lymphoblastic leukemia (NCIt: C7953)
Precursor T-cell acute lymphoblastic leukemia (ORDO: Orphanet_99861)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0367 (Jurkat E6.1)
Sex of cell Male
Age at sampling 14Y
Category Cancer cell line
STR profile Source(s): ATCC; PubMed=25877200

Markers:
AmelogeninX,Y
CSF1PO11,12
D3S135814,17
D5S8189
D7S8208,9.3,10.3
D8S117914,15
D13S3178,11,12
D16S53911
D18S5113,21,22
D21S1131.2,33.2,34.2
FGA20,21
Penta D11,13
Penta E10,12
TH016,9.3
TPOX8,10
vWA18

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Publications

PubMed=1672451; DOI=10.1073/pnas.88.6.2037
Koretzky G.A., Picus J., Schultz T., Weiss A.
Tyrosine phosphatase CD45 is required for T-cell antigen receptor and CD2-mediated activation of a protein tyrosine kinase and interleukin 2 production.
Proc. Natl. Acad. Sci. U.S.A. 88:2037-2041(1991)

Cross-references
Cell line collections ATCC; CRL-1990
BCRC; 60255
ECACC; 93031145
Cell line databases/resources CLDB; cl2921
LINCS_LDP; LCL-1029
Ontologies CLO; CLO_0006998
Biological sample resources BioSample; SAMN03470881
Other Wikidata; Q54898471
Entry history
Entry creation04-Apr-2012
Last entry update12-Jan-2021
Version number23