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Cellosaurus MCC13 (CVCL_2583)

[Text version]

Cell line name MCC13
Synonyms MCC13TC; MCC13 TC
Accession CVCL_2583
Resource Identification Initiative To cite this cell line use: MCC13 (RRID:CVCL_2583)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Part of: COSMIC cell lines project.
Doubling time: 1 day (PubMed=20444890).
Omics: Deep exome analysis.
Sequence variations Heterozygous for TP53 p.Ser241Pro (c.721T>C) and p.Pro278Ser (c.832C>T) (PubMed=10732753; PubMed=23563200).
Genome ancestry Source: PubMed=30894373

Origin% genome
African0
Native American0
East Asian, North0
East Asian, South1.16
South Asian3.02
European, North64.74
European, South31.08
Disease Merkel cell carcinoma (NCIt: C9231)
Derived from metastatic site: Cervical lymph node.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 80Y
Category Cancer cell line
STR profile Source(s): CBA

Markers:
AmelogeninX
CSF1PO12
D2S133819,20
D3S135816,18
D5S8189,12
D7S82010
D8S117913,14
D13S31712
D16S5399,11
D18S5116,17
D19S43315
D21S1130,31
FGA19,20
TH017,9.3
TPOX8
vWA17

Run an STR similarity search on this cell line
Publications

PubMed=8026890; DOI=10.1002/ijc.2910580223
Thomson J.A.F., Leonard J.H., McGregor K., Sturm R.A., Parsons P.G.
A nonconsensus octamer-recognition sequence (TAATGARAT-motif) identifies a novel DNA binding protein in human Merkel cell carcinoma cell lines.
Int. J. Cancer 58:285-290(1994)

PubMed=7814141; DOI=10.1002/ijc.2910600115
Leonard J.H., Dash P., Holland P., Kearsley J.H., Bell J.R.
Characterisation of four Merkel cell carcinoma adherent cell lines.
Int. J. Cancer 60:100-107(1995)

PubMed=10732753; DOI=10.1054/bjoc.1999.1006
Van Gele M., Kaghad M., Leonard J.H., Van Roy N., Naeyaert J.M., Geerts M.L., Van Belle S., Cocquyt V., Bridge J., Sciot R., De Wolf-Peeters C., De Paepe A., Caput D., Speleman F.
Mutation analysis of P73 and TP53 in Merkel cell carcinoma.
Br. J. Cancer 82:823-826(2000)

PubMed=11433400; DOI=10.1002/ijc.1352
Cook A.L., Pollock P.M., Welch J., Walsh M.D., Bowman R.V., Baumann K.C., Hayward N.K., Leonard J.H.
CDKN2A is not the principal target of deletions on the short arm of chromosome 9 in neuroendocrine (Merkel cell) carcinoma of the skin.
Int. J. Cancer 93:361-367(2001)

PubMed=12209986; DOI=10.1002/ijc.10554
Leonard J.H., Cook A.L., Van Gele M., Boyle G.M., Inglis K.J., Speleman F., Sturm R.A.
Proneural and proneuroendocrine transcription factor expression in cutaneous mechanoreceptor (Merkel) cells and Merkel cell carcinoma.
Int. J. Cancer 101:103-110(2002)

PubMed=12209990; DOI=10.1002/ijc.10591
Van Gele M., Leonard J.H., Van Roy N., Van Limbergen H., Van Belle S., Cocquyt V., Salwen H.R., De Paepe A., Speleman F.
Combined karyotyping, CGH and M-FISH analysis allows detailed characterization of unidentified chromosomal rearrangements in Merkel cell carcinoma.
Int. J. Cancer 101:137-145(2002)

PubMed=20444890; DOI=10.1128/JVI.02400-09
Houben R., Shuda M., Weinkam R., Schrama D., Feng H., Chang Y., Moore P.S., Becker J.C.
Merkel cell polyomavirus-infected Merkel cell carcinoma cells require expression of viral T antigens.
J. Virol. 84:7064-7072(2010)

PubMed=22363598; DOI=10.1371/journal.pone.0031255
Hafner C., Houben R., Baeurle A., Ritter C., Schrama D., Landthaler M., Becker J.C.
Activation of the PI3K/AKT pathway in Merkel cell carcinoma.
PLoS ONE 7:E31255-E31255(2012)

PubMed=23563200; DOI=10.1038/jid.2013.169
Houben R., Dreher C., Angermeyer S., Borst A., Utikal J., Haferkamp S., Peitsch W.K., Schrama D., Hesbacher S.
Mechanisms of p53 restriction in Merkel cell carcinoma cells are independent of the Merkel cell polyoma virus T antigens.
J. Invest. Dermatol. 133:2453-2460(2013)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z., Monteiro A.N., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

Cross-references
Cell line collections CBA; CBA-1338
ECACC; 10092302
Cell line databases/resources CCLE; MCC13_SKIN
Cell_Model_Passport; SIDM00007
Cosmic-CLP; 1333003
DepMap; ACH-001550
GDSC; 1333003
Biological sample resources BioSample; SAMN07624419
Other Wikidata; Q54904252
Polymorphism and mutation databases Cosmic; 912929
Cosmic; 1693075
Cosmic; 1699815
Cosmic; 2273913
IARC_TP53; 12477
Entry history
Entry creation04-Apr-2012
Last entry updated05-Jul-2019
Version number18