Cellosaurus MCC13 (CVCL_2583)

Cell line name MCC13
Synonyms MCC13TC; MCC13 TC
Accession CVCL_2583
Resource Identification Initiative To cite this cell line use: MCC13 (RRID:CVCL_2583)
Comments Part of: COSMIC cell lines project.
Doubling time: 1 day (PubMed=20444890).
Omics: Deep exome analysis.
Sequence variations Heterozygous for TP53 p.Ser241Pro (c.721T>C) and p.Pro278Ser (c.832C>T) (PubMed=23563200).
Disease Merkel cell carcinoma (NCIt: C9231)
Derived from metastatic site: Cervical lymph node.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 80Y
Category Cancer cell line
STR profile Source(s): CBA

Markers:
AmelogeninX
CSF1PO12
D13S31712
D16S5399,11
D18S5116,17
D19S43315
D21S1130,31
D2S133819,20
D3S135816,18
D5S8189,12
D7S82010
D8S117913,14
FGA19,20
TH017,9.3
TPOX8
vWA17
Publications

PubMed=7814141; DOI=10.1002/ijc.2910600115
Leonard J.H., Dash P., Holland P., Kearsley J.H., Bell J.R.
Characterisation of four Merkel cell carcinoma adherent cell lines.
Int. J. Cancer 60:100-107(1995)

PubMed=12209990; DOI=10.1002/ijc.10591
Van Gele M., Leonard J.H., Van Roy N., Van Limbergen H., Van Belle S., Cocquyt V., Salwen H.R., De Paepe A., Speleman F.
Combined karyotyping, CGH and M-FISH analysis allows detailed characterization of unidentified chromosomal rearrangements in Merkel cell carcinoma.
Int. J. Cancer 101:137-145(2002)

PubMed=20444890; DOI=10.1128/JVI.02400-09
Houben R., Shuda M., Weinkam R., Schrama D., Feng H., Chang Y., Moore P.S., Becker J.C.
Merkel cell polyomavirus-infected Merkel cell carcinoma cells require expression of viral T antigens.
J. Virol. 84:7064-7072(2010)

PubMed=23563200; DOI=10.1038/jid.2013.169
Houben R., Dreher C., Angermeyer S., Borst A., Utikal J., Haferkamp S., Peitsch W.K., Schrama D., Hesbacher S.
Mechanisms of p53 restriction in Merkel cell carcinoma cells are independent of the Merkel cell polyoma virus T antigens.
J. Invest. Dermatol. 133:2453-2460(2013)

Cross-references
Cell line collections CBA; CBA-1338
ECACC; 10092302
Cell line databases/resources Cosmic-CLP; 1333003
GDSC; 1333003
Biological sample resources BioSample; SAMN07624419
Other Wikidata; Q54904252
Polymorphism and mutation databases Cosmic; 912929
Cosmic; 1693075
Cosmic; 1699815
Cosmic; 2273913