Cellosaurus MES-SA/Dx5 (CVCL_2598)

Cell line name MES-SA/Dx5
Synonyms MES-SA/Dx-5; MES-SA-Dx5; MES-SA Dx5; MESSA/Dx5; MESSA-DX5; MESSA Dx5; MESSADX5; Dx5
Accession CVCL_2598
Resource Identification Initiative To cite this cell line use: MES-SA/Dx5 (RRID:CVCL_2598)
Comments Part of: MD Anderson Cell Lines Project.
Doubling time: 30 hours (ECACC).
Selected for resistance to: ChEBI; CHEBI:28748; Doxorubicin (Adriablastin; Adriamycin).
Omics: Protein expression by reverse-phase protein arrays.
Omics: Proteome analysis by 2D-DE/MS.
Misspelling: MES-SA/DxS; In ChEMBL-Targets CHEMBL613827 and ChEMBL-Cells CHEMBL3308373.
Disease Uterine corpus sarcoma (NCIt: C6339)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1404 (MES-SA)
Children: CVCL_4T94 (MES-SA/DxP5002)
Sex of cell Female
Category Cancer cell line
STR profile Source(s): ATCC; PubMed=25877200

Markers:
AmelogeninX
CSF1PO11
D13S31713
D16S53911,12
D18S5115
D19S43314.2,15
D21S1129,30.2
D2S133817
D3S135814,17
D5S81813
D7S8207,11 (ATCC)
11 (PubMed=25877200)
D8S117914,15
FGA20,25
Penta D13,15
Penta E7,10
TH016
TPOX8,11
vWA18
Web pages http://tcpaportal.org/mclp/
Publications

PubMed=4028002
Harker W.G., Sikic B.I.
Multidrug (pleiotropic) resistance in doxorubicin-selected variants of the human sarcoma cell line MES-SA.
Cancer Res. 45:4091-4096(1985)

PubMed=22889595; DOI=10.1016/j.jprot.2012.07.047
Lin S.-T., Chou H.-C., Chang S.-J., Chen Y.-W., Lyu P.-C., Wang W.-C., Chang M.D.-T., Chan H.-L.
Proteomic analysis of proteins responsible for the development of doxorubicin resistance in human uterine cancer cells.
J. Proteomics 75:5822-5847(2012)

PubMed=26351324; DOI=10.1158/1535-7163.MCT-15-0074
Teicher B.A., Polley E., Kunkel M., Evans D., Silvers T.E., Delosh R.M., Laudeman J., Ogle C., Reinhart R., Selby M., Connelly J., Harris E., Monks A., Morris J.
Sarcoma cell line screen of oncology drugs and investigational agents identifies patterns associated with gene and microRNA expression.
Mol. Cancer Ther. 14:2452-2462(2015)

PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005
Li J., Zhao W., Akbani R., Liu W., Ju Z., Ling S., Vellano C.P., Roebuck P., Yu Q., Eterovic A.K., Byers L.A., Davies M.A., Deng W., Gopal Y.N.V., Chen G., von Euw E.M., Slamon D.J., Conklin D., Heymach J.V., Gazdar A.F., Minna J.D., Myers J.N., Lu Y., Mills G.B., Liang H.
Characterization of human cancer cell lines by reverse-phase protein arrays.
Cancer Cell 31:225-239(2017)

Cross-references
Cell line collections ATCC; CRL-1977 - Discontinued
BCRC; 60331
ECACC; 95051031
Cell line databases/resources CLDB; cl3449
IGRhCellID; MESSADX5
LINCS_LDP; LCL-1510
Ontologies CLO; CLO_0007678
Biological sample resources BioSample; SAMN03470985
BioSample; SAMN03471267
Chemistry resources ChEMBL-Cells; CHEMBL3308373
ChEMBL-Targets; CHEMBL613827
Gene expression databases GEO; GSM827348
GEO; GSM1676305
GEO; GSM1701640