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Cellosaurus MES-SA/MX2 (CVCL_2599)

[Text version]
Cell line name MES-SA/MX2
Synonyms MES-SA/Mx2; MES-SA-MX2; MESSA/MX2; MESSAMX2
Accession CVCL_2599
Resource Identification Initiative To cite this cell line use: MES-SA/MX2 (RRID:CVCL_2599)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI:50729; Mitoxantrone.
Omics: SNP array analysis.
Derived from site: In situ; Uterus; UBERON=UBERON_0000995.
Sequence variations
  • Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 11110; ARID1A; Simple; p.Gly1610Trpfs*38 (c.4826dupC) (p.S1609fs) (c.4825_4826insC); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 11110; ARID1A; Simple; p.Thr1690Asnfs*8 (c.5068dupA) (c.5067_5068insA); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 9588; PTEN; Simple; p.His272Thrfs*4 (c.813delT) (p.Phe271fs) (c.811delT); ClinVar=VCV000428208; Zygosity=Heterozygous (from parent cell line).
Disease Uterine corpus sarcoma (NCIt: C6339)
Sarcoma of the corpus uteri (ORDO: Orphanet_213620)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1404 (MES-SA)
Sex of cell Female
Age at sampling 56Y
Category Cancer cell line
STR profile Source(s): ATCC

Markers:
AmelogeninX
CSF1PO11
D5S81813
D7S8207,11
D13S31713
D16S53911,12
TH016
TPOX8,12
vWA18

Run an STR similarity search on this cell line
Publications

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458
Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A.
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

Cross-references
Cell line collections (Providers) ATCC; CRL-2274
Cell line databases/resources CLO; CLO_0007679
cancercelllines; CVCL_2599
Cell_Model_Passport; SIDM01239
IGRhCellID; MESSAMX2
Biological sample resources BioSample; SAMN03471858
Encyclopedic resources Wikidata; Q54905252
Gene expression databases ArrayExpress; E-MTAB-38
Polymorphism and mutation databases Progenetix; CVCL_2599
Entry history
Entry creation04-Apr-2012
Last entry update05-Oct-2023
Version number19