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Cellosaurus MM370 (CVCL_2605)

[Text version]
Cell line name MM370
Synonyms MM 370
Accession CVCL_2605
Resource Identification Initiative To cite this cell line use: MM370 (RRID:CVCL_2605)
Comments Problematic cell line: Misidentified. Presence of a Y chromosome in cell line that was thought to be of female origin.
Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Omics: CNV analysis.
Omics: Deep exome analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis by microarray.
Derived from site: Metastatic; Lymph node; UBERON=UBERON_0000027.
Sequence variations
  • Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (PubMed=17363583).
  • Mutation; HGNC; 1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Unspecified (PubMed=15048078; PubMed=17363583; DepMap).
Disease Melanoma (NCIt: C3224)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling Age unspecified
Category Cancer cell line
STR profile Source(s): CBA

Markers:
AmelogeninX,Y
CSF1PO11,12
D2S133817
D3S135814,16
D5S81811,12
D7S82011,12
D8S117913,14
D13S31711,12
D16S5398
D18S5114,15
D19S43312,13
D21S1127,32
FGA21,24
TH019.3
TPOX8,9
vWA14,18

Run an STR similarity search on this cell line
Publications

PubMed=3756862
Maynard K., Parsons P.G.
Cross-sensitivity of methylating agents, hydroxyurea, and methotrexate in human tumor cells of the Mer- phenotype.
Cancer Res. 46:5009-5013(1986)

PubMed=9354451
Castellano M., Pollock P.M., Walters M.K., Sparrow L.E., Down L.M., Gabrielli B.G., Parsons P.G., Hayward N.K.
CDKN2A/p16 is inactivated in most melanoma cell lines.
Cancer Res. 57:4868-4875(1997)

PubMed=10070891; DOI=10.1038/sj.bjc.6690147
Zerp S.F., van Elsas A., Peltenburg L.T.C., Schrier P.I.
p53 mutations in human cutaneous melanoma correlate with sun exposure but are not always involved in melanomagenesis.
Br. J. Cancer 79:921-926(1999)

PubMed=15048078; DOI=10.1038/sj.onc.1207563
Pavey S., Johansson P., Packer L., Taylor J., Stark M.S., Pollock P.M., Walker G.J., Boyle G.M., Harper U., Cozzi S.-J., Hansen K., Yudt L., Schmidt C., Hersey P., Ellem K.A.O., O'Rourke M.G.E., Parsons P.G., Meltzer P.S., Ringner M., Hayward N.K.
Microarray expression profiling in melanoma reveals a BRAF mutation signature.
Oncogene 23:4060-4067(2004)

PubMed=17363583; DOI=10.1158/0008-5472.CAN-06-4152
Stark M.S., Hayward N.K.
Genome-wide loss of heterozygosity and copy number analysis in melanoma using high-density single-nucleotide polymorphism arrays.
Cancer Res. 67:2632-2642(2007)

PubMed=17516929; DOI=10.1111/j.1600-0749.2007.00375.x
Johansson P., Pavey S., Hayward N.K.
Confirmation of a BRAF mutation-associated gene expression signature in melanoma.
Pigment Cell Res. 20:216-221(2007)

Cross-references
Cell line collections (Providers) CBA; CBA-1348
ECACC; 10092316
Cell line databases/resources cancercelllines; CVCL_2605
Cell_Model_Passport; SIDM01355
DepMap; ACH-001566
Biological sample resources BioSample; SAMN07624426
Encyclopedic resources Wikidata; Q54906115
Gene expression databases GEO; GSM162929
GEO; GSM226658
Polymorphism and mutation databases Cosmic; 889018
Cosmic; 928747
Progenetix; CVCL_2605
Entry history
Entry creation04-Apr-2012
Last entry update05-Oct-2023
Version number23