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Cellosaurus OE21 (CVCL_2661)

[Text version]

Cell line name OE21
Synonyms OE-21; JROECL 21; JROECL21
Accession CVCL_2661
Resource Identification Initiative To cite this cell line use: OE21 (RRID:CVCL_2661)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Part of: COSMIC cell lines project.
Part of: KuDOS 95 cell line panel.
Part of: TCGA-110-CL cell line panel.
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Deep exome analysis.
Omics: Deep RNAseq analysis.
Omics: DNA methylation analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Genome ancestry Source: PubMed=30894373

Origin% genome
African0
Native American0
East Asian, North1.35
East Asian, South0.2
South Asian0
European, North64.63
European, South33.81
Disease Esophageal squamous cell carcinoma (NCIt: C4024)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 74Y
Category Cancer cell line
STR profile Source(s): Cosmic-CLP; ECACC; PubMed=25877200

Markers:
AmelogeninX (Cosmic-CLP)
X,Y (ECACC; PubMed=25877200)
CSF1PO11,12
D2S133817,19
D3S135817
D5S81813 (Cosmic-CLP)
12,13 (ECACC; PubMed=25877200)
D7S82011,12
D8S117912
D13S31712
D16S53912,13 (Cosmic-CLP; PubMed=25877200)
13 (ECACC)
D18S5119
D19S43315.2
D21S1130,31
FGA20
Penta D11,12
Penta E12
TH017,8 (Cosmic-CLP)
8 (ECACC; PubMed=25877200)
TPOX8,11
vWA15,16 (Cosmic-CLP)
16,17 (ECACC; PubMed=25877200)

Run an STR similarity search on this cell line
Publications

PubMed=9010035; DOI=10.1038/bjc.1997.42
Rockett J.C., Larkin K., Darnton S.J., Morris A.G., Matthews H.R.
Five newly established oesophageal carcinoma cell lines: phenotypic and immunological characterization.
Br. J. Cancer 75:258-263(1997)

PubMed=16364037; DOI=10.1111/j.1442-2050.2006.00530.x
Su M., Chin S.-F., Li X.-Y., Edwards P., Caldas C., Fitzgerald R.C.
Comparative genomic hybridization of esophageal adenocarcinoma and squamous cell carcinoma cell lines.
Dis. Esophagus 19:10-14(2006)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458
Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A.
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=22460905; DOI=10.1038/nature11003
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.K., Yu J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=26512696; DOI=10.3390/cancers7040881
O'Callaghan C., Fanning L.J., Barry O.P.
Hypermethylation of MAPK13 promoter in oesophageal squamous cell carcinoma is associated with loss of p38delta MAPK expression.
Cancers (Basel) 7:2124-2133(2015)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z., Monteiro A.N., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3
Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. III, Barretina J., Gelfand E.T., Bielski C.M., Li H., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R.
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

PubMed=31395879; DOI=10.1038/s41467-019-11415-2
Yu K., Chen B., Aran D., Charalel J., Yau C., Wolf D.M., van 't Veer L.J., Butte A.J., Goldstein T., Sirota M.
Comprehensive transcriptomic analysis of cell lines as models of primary tumors across 22 tumor types.
Nat. Commun. 10:3574-3574(2019)

Cross-references
Cell line collections ECACC; 96062201
Cell line databases/resources CLDB; cl5089
CCLE; OE21_OESOPHAGUS
Cell_Model_Passport; SIDM00478
Cosmic-CLP; 1298359
DepMap; ACH-000544
IGRhCellID; OE21
LINCS_LDP; LCL-1558
Ontologies BTO; BTO:0004489
CLO; CLO_0008239
EFO; EFO_0002309
Biological sample resources BioSample; SAMN03472891
BioSample; SAMN10989579
Chemistry resources GDSC; 1298359
PharmacoDB; OE21_1195_2019
Gene expression databases ArrayExpress; E-MTAB-2770
ArrayExpress; E-MTAB-3610
GEO; GSM827300
GEO; GSM888556
GEO; GSM1374796
GEO; GSM1374797
GEO; GSM1375727
GEO; GSM1375728
GEO; GSM1375729
GEO; GSM1375730
GEO; GSM1375739
GEO; GSM1375740
GEO; GSM1375741
GEO; GSM1375742
GEO; GSM1375751
GEO; GSM1375752
GEO; GSM1375753
GEO; GSM1375754
GEO; GSM1670303
Other Wikidata; Q54931864
Polymorphism and mutation databases Cosmic; 1339912
Cosmic; 1995601
Cosmic; 2009522
LiGeA; CCLE_787
Entry history
Entry creation04-Apr-2012
Last entry updated19-Dec-2019
Version number27