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Cellosaurus OV17R (CVCL_2672)

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Cell line name OV17R
Synonyms OV-17R
Accession CVCL_2672
Resource Identification Initiative To cite this cell line use: OV17R (RRID:CVCL_2672)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Part of: COSMIC cell lines project.
Part of: OCCP ovarian cancer cell line panel.
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Deep exome analysis.
Omics: Deep RNAseq analysis.
Omics: DNA methylation analysis.
Omics: Transcriptome analysis.
Sequence variations Mutation; HGNC; 583; APC; Simple; p.Glu1317Gln (c.3949G>C); ClinVar=VCV000000829; Zygosity=Unspecified (PubMed=25230021).
Mutation; HGNC; 11998; TP53; Simple; p.Val216Met (c.646G>A); ClinVar=VCV000182965; Zygosity=Unspecified (PubMed=25230021; PubMed=28273451; CCLE).
Genome ancestry Source: PubMed=30894373

Origin% genome
Native American0
East Asian, North1.99
East Asian, South0
South Asian0
European, North60.17
European, South35.44
Disease Ovarian adenocarcinoma (NCIt: C7700)
Adenocarcinoma of ovary (ORDO: Orphanet_213504)
Derived from metastatic site: Ascites.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 50Y
Category Cancer cell line
STR profile Source(s): Cosmic-CLP; DepMap; ECACC; PubMed=25230021

Penta D10,13
Penta E14
TH019 (Cosmic-CLP; ECACC)
9,9.3 (DepMap; PubMed=25230021)

Run an STR similarity search on this cell line

PubMed=7707437; DOI=10.1093/jnci/87.7.506
Boocock C.A., Charnock-Jones D.S., Sharkey A.M., McLaren J., Barker P.J., Wright K.A., Twentyman P.R., Smith S.K.
Expression of vascular endothelial growth factor and its receptors flt and KDR in ovarian carcinoma.
J. Natl. Cancer Inst. 87:506-516(1995)

PubMed=25230021; DOI=10.1371/journal.pone.0103988
Beaufort C.M., Helmijr J.C.A., Piskorz A.M., Hoogstraat M., Ruigrok-Ritstier K., Besselink N., Murtaza M., van IJcken W.F.J., Heine A.A.J., Smid M., Koudijs M.J., Brenton J.D., Berns E.M.J.J., Helleman J.
Ovarian cancer cell line panel (OCCP): clinical importance of in vitro morphological subtypes.
PLoS ONE 9:E103988-E103988(2014)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=28273451; DOI=10.1016/j.celrep.2017.02.028
Medrano M., Communal L., Brown K.R., Iwanicki M., Normand J., Paterson J., Sircoulomb F., Krzyzanowski P.M., Novak M., Doodnauth S.A., Suarez Saiz F.J., Cullis J., Al-Awar R., Neel B.G., McPherson J., Drapkin R.I., Ailles L., Mes-Masson A.-M., Rottapel R.
Interrogation of functional cell-surface markers identifies CD151 dependency in high-grade serous ovarian cancer.
Cell Rep. 18:2343-2358(2017)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

Cell line collections ECACC; 96020763
Cell line databases/resources CCLE; OV17R_OVARY
Cell_Model_Passport; SIDM00476
Cosmic-CLP; 1480361
DepMap; ACH-001373
Chemistry resources GDSC; 1480361
PharmacoDB; OV17R_1209_2019
Gene expression databases ArrayExpress; E-MTAB-3610
GEO; GSM711699
GEO; GSM1291145
GEO; GSM1670311
GEO; GSM2474981
Other Wikidata; Q54936883
Entry history
Entry creation04-Apr-2012
Last entry update20-May-2021
Version number21