Cellosaurus P3HR-1 (CVCL_2676)

Cell line name P3HR-1
Synonyms P 3 HR 1; P3HR1; P3HRI; P3HR1-BL; P3J HR-1; P3J-HR-1; P3JHR-1; P3JHR1; P3J HR1-K; P3J.HR1K; HR-1; HR1K
Accession CVCL_2676
Resource Identification Initiative To cite this cell line use: P3HR-1 (RRID:CVCL_2676)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Part of: MD Anderson Cell Lines Project.
Part of: MYC genetic alteration cell panel (ATCC TCP-1035).
Sequence variation: TP53 p.Tyr163His and p.Glu287Ter (PubMed=2052620; PubMed=8344493).
Transformant: NCBI_TaxID; 10376; Epstein-Barr virus (EBV).
Omics: Protein expression by reverse-phase protein arrays.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Omics: Virome analysis using RNAseq.
Disease Epstein-Barr virus-related Burkitt lymphoma (NCIt: C27694)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1317 (Jiyoye)
Children: CVCL_X203 (D98/HR-1); CVCL_IU56 (FF452-3); CVCL_IU57 (GG618-13); CVCL_W740 (HH514-16); CVCL_W741 (HH543-5); CVCL_B066 (P3H3); CVCL_2697 (Putko); CVCL_6218 (RUD-PICAT-1); CVCL_6219 (RUDPUT-2); CVCL_8428 (TDL-1); CVCL_8429 (TDL-2)
Sex of cell Male
Category Cancer cell line
STR profile Source(s): ATCC; ECACC

Markers:
AmelogeninX,Y (ATCC)
X (ECACC)
CSF1PO10,11
D13S31712
D16S53910,11
D5S81812
D7S8208,10
TH017,9
TPOX6,8
vWA15,19
Web pages http://www.rccc.cytspb.rssi.ru/RussianCellBank/CellLinePerson/clP3HR-1%28P3J-HR1K%29.htm
http://tcpaportal.org/mclp/
Publications

PubMed=4912237
Hinuma Y., Konn M., Yamaguchi J., Wudarski D.J., Blakeslee J.R. Jr., Grace J.T. Jr.
Immunofluorescence and herpes-type virus particles in the P3HR-1 Burkitt lymphoma cell line.
J. Virol. 1:1045-1051(1967)

PubMed=4321974
Maurer B.A., Wilbert S.M., Imamura T.
Incidence of EB virus-containing cells in primary and secondary clones of several Burkitt lymphoma cell lines.
Cancer Res. 30:2870-2875(1970)

PubMed=4932228; DOI=10.1002/ijc.2910070214
Gergely L., Klein G., Ernberg I.
The action of DNA antagonists on Epstein-Barr virus (EBV)-associated early antigen (EA) in Burkitt lymphoma lines.
Int. J. Cancer 7:293-302(1971)

PubMed=4115493
Petit P., Verhest A., Lecluse van der Bilt F., Jongsma A.P.M.
The chromosomes of the EB virus-positive Burkitt cell line P3J.HR1K studied by the fluorescent staining technique.
Pathol. Eur. 7:17-21(1972)

PubMed=4122458; DOI=10.1002/ijc.2910100108
Klein G., Dombos L., Gothoskar B.
Sensitivity of Epstein-Barr virus (EBV) producer and non-producer human lymphoblastoid cell lines to superinfection with EB-virus.
Int. J. Cancer 10:44-57(1972)

PubMed=4364259; DOI=10.1002/ijc.2910110210
Klein G., Dombos L.
Relationship between the sensitivity of EBV-carrying lymphoblastoid lines to superinfection and the inducibility of the resident viral genome.
Int. J. Cancer 11:327-337(1973)

PubMed=170370; DOI=10.1099/0022-1317-28-2-207
Adams A., Strander H., Cantell K.
Sensitivity of the Epstein-Barr virus transformed human lymphoid cell lines to interferon.
J. Gen. Virol. 28:207-217(1975)

PubMed=327080; DOI=10.1093/jnci/59.1.221
Fogh J., Fogh J.M., Orfeo T.
One hundred and twenty-seven cultured human tumor cell lines producing tumors in nude mice.
J. Natl. Cancer Inst. 59:221-226(1977)

PubMed=6265077
Pizzo P.A., Chattopadhyay S.K., Magrath I.T., Del Giacco E., Sherrick D., Gray T.
Examination of Epstein-Barr virus and C-type proviral sequences in American and African lymphomas and derivative cell lines.
Cancer Res. 41:3165-3171(1981)

PubMed=6286763
Benjamin D., Magrath I.T., Maguire R.T., Janus C., Todd H.D., Parsons R.G.
Immunoglobulin secretion by cell lines derived from African and American undifferentiated lymphomas of Burkitt's and non-Burkitt's type.
J. Immunol. 129:1336-1342(1982)

PubMed=3518877; DOI=10.3109/07357908609038260
Fogh J.
Human tumor lines for cancer research.
Cancer Invest. 4:157-184(1986)

PubMed=1915267
Farrell P.J., Allan G.J., Shanahan F., Vousden K.H., Crook T.
p53 is frequently mutated in Burkitt's lymphoma cell lines.
EMBO J. 10:2879-2887(1991)

PubMed=2052620; DOI=10.1073/pnas.88.12.5413
Gaidano G., Ballerini P., Gong J.Z., Inghirami G., Neri A., Newcomb E.W., Magrath I.T., Knowles D.M., Dalla-Favera R.
p53 mutations in human lymphoid malignancies: association with Burkitt lymphoma and chronic lymphocytic leukemia.
Proc. Natl. Acad. Sci. U.S.A. 88:5413-5417(1991)

PubMed=8344493
Bhatia K., Goldschmidts W., Gutierrez M.I., Gaidano G., Dalla-Favera R., Magrath I.T.
Hemi- or homozygosity: a requirement for some but not other p53 mutant proteins to accumulate and exert a pathogenetic effect.
FASEB J. 7:951-956(1993)

PubMed=12967475; DOI=10.1111/j.1349-7006.2003.tb01518.x
Maesako Y., Uchiyama T., Ohno H.
Comparison of gene expression profiles of lymphoma cell lines from transformed follicular lymphoma, Burkitt's lymphoma and de novo diffuse large B-cell lymphoma.
Cancer Sci. 94:774-781(2003)

PubMed=19358282; DOI=10.1002/ijc.24351
Inagaki A., Ishida T., Yano H., Ishii T., Kusumoto S., Ito A., Ri M., Mori F., Ding J., Komatsu H., Iida S., Ueda R.
Expression of the ULBP ligands for NKG2D by B-NHL cells plays an important role in determining their susceptibility to rituximab-induced ADCC.
Int. J. Cancer 125:212-221(2009)

PubMed=22460905; DOI=10.1038/nature11003
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.K., Yu J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L., Winckler W., Reich M., Li N., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=25355872; DOI=10.1128/JVI.02570-14
Cao S., Strong M.J., Wang X., Moss W.N., Concha M., Lin Z., O'Grady T., Baddoo M., Fewell C., Renne R., Flemington E.K.
High-throughput RNA sequencing-based virome analysis of 50 lymphoma cell lines from the Cancer Cell Line Encyclopedia project.
J. Virol. 89:713-729(2015)

PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005
Li J., Zhao W., Akbani R., Liu W., Ju Z., Ling S., Vellano C.P., Roebuck P., Yu Q., Eterovic A.K., Byers L.A., Davies M.A., Deng W., Gopal Y.N.V., Chen G., von Euw E.M., Slamon D.J., Conklin D., Heymach J.V., Gazdar A.F., Minna J.D., Myers J.N., Lu Y., Mills G.B., Liang H.
Characterization of human cancer cell lines by reverse-phase protein arrays.
Cancer Cell 31:225-239(2017)

Cross-references
Cell line collections ATCC; HTB-62
BCRJ; 0338
ECACC; 86010701
IZSLER; BS TCL 99
Cell line databases/resources CLDB; cl3837
CLDB; cl5159
CLDB; cl5242
CCLE; P3HR1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE
CGH-DB; 9199-4
GDSC; 1330988
IGRhCellID; P3HR1
LINCS_LDP; LCL-2024
Ontologies CLO; CLO_0008282
CLO; CLO_0008331
EFO; EFO_0002312
Chemistry resources ChEMBL-Cells; CHEMBL3307242
ChEMBL-Targets; CHEMBL612705
Gene expression databases GEO; GSM887493
GEO; GSM888575
Polymorphism and mutation databases Cosmic; 724830
Cosmic; 1517661