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Cellosaurus RCC4/VHL (CVCL_2706)

[Text version]

Cell line name RCC4/VHL
Synonyms RCC4plusVHL; RCC4 VHL(+); RCC4-pVHL
Accession CVCL_2706
Resource Identification Initiative To cite this cell line use: RCC4/VHL (RRID:CVCL_2706)
Comments Transfected with: HGNC; 12687; VHL.
Transfected with: UniProtKB; P00552; Transposon Tn5 neo.
Sequence variations Hemizygous for VHL p.Ser65Trp (c.194C>G) (from parent cell line).
Disease Clear cell renal cell carcinoma (NCIt: C4033)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0498 (RCC4)
Category Cancer cell line
STR profile Source(s): ECACC

Markers:
AmelogeninX
CSF1PO10,12
D5S81812
D7S8208.2
D13S31711,12
D16S53911
TH019.3
TPOX11
vWA16

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Publications

PubMed=10353251; DOI=10.1038/20459
Maxwell P.H., Wiesener M.S., Chang G.-W., Clifford S.C., Vaux E.C., Cockman M.E., Wykoff C.C., Pugh C.W., Maher E.R., Ratcliffe P.J.
The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis.
Nature 399:271-275(1999)

PubMed=21258414; DOI=10.1038/onc.2010.638
Perier A., Fregni G., Wittnebel S., Gad S., Allard M., Gervois N., Escudier B., Azzarone B., Caignard A.
Mutations of the von Hippel-Lindau gene confer increased susceptibility to natural killer cells of clear-cell renal cell carcinoma.
Oncogene 30:2622-2632(2011)

PubMed=22949125; DOI=10.1002/ijc.27822
Pawlowski R., Muhl S.M., Sulser T., Krek W., Moch H., Schraml P.
Loss of PBRM1 expression is associated with renal cell carcinoma progression.
Int. J. Cancer 132:E11-E17(2013)

Cross-references
Cell line collections ECACC; 03112703
Other Wikidata; Q54949465
Entry history
Entry creation04-Apr-2012
Last entry updated24-May-2019
Version number10