ID   RCC4/VHL
AC   CVCL_2706
SY   RCC4plusVHL; RCC4 VHL(+); RCC4-pVHL
DR   cancercelllines; CVCL_2706
DR   Cell_Model_Passport; SIDM01920
DR   ChEMBL-Cells; CHEMBL4483154
DR   ChEMBL-Targets; CHEMBL4483265
DR   ECACC; 03112703
DR   PubChem_Cell_line; CVCL_2706
DR   Wikidata; Q54949465
RX   PubMed=10353251;
RX   PubMed=21258414;
RX   PubMed=22949125;
CC   Population: Caucasian.
CC   Sequence variation: Mutation; HGNC; 12687; VHL; Simple; p.Ser65Trp (c.194C>G); ClinVar=VCV000043597; Zygosity=Hemizygous (from parent cell line).
CC   Transfected with: HGNC; 12687; VHL.
CC   Transfected with: UniProtKB; P00552; Transposon Tn5 neo.
CC   Derived from site: In situ; Kidney; UBERON=UBERON_0002113.
ST   Source(s): ECACC
ST   Amelogenin: X
ST   CSF1PO: 10,12
ST   D13S317: 11,12
ST   D16S539: 11
ST   D5S818: 12
ST   D7S820: 8.2
ST   TH01: 9.3
ST   TPOX: 11
ST   vWA: 16
DI   NCIt; C4033; Clear cell renal cell carcinoma
DI   ORDO; Orphanet_319276; Clear cell renal carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0498 ! RCC4
SX   Sex unspecified
AG   Age unspecified
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 05-10-23; Version: 17
//
RX   PubMed=10353251; DOI=10.1038/20459;
RA   Maxwell P.H., Wiesener M.S., Chang G.-W., Clifford S.C., Vaux E.C.,
RA   Cockman M.E., Wykoff C.C., Pugh C.W., Maher E.R., Ratcliffe P.J.;
RT   "The tumour suppressor protein VHL targets hypoxia-inducible factors
RT   for oxygen-dependent proteolysis.";
RL   Nature 399:271-275(1999).
//
RX   PubMed=21258414; DOI=10.1038/onc.2010.638;
RA   Perier A., Fregni G., Wittnebel S., Gad S., Allard M.,
RA   Gervois-Segain N., Escudier B.J., Azzarone B., Caignard A.;
RT   "Mutations of the von Hippel-Lindau gene confer increased
RT   susceptibility to natural killer cells of clear-cell renal cell
RT   carcinoma.";
RL   Oncogene 30:2622-2632(2011).
//
RX   PubMed=22949125; DOI=10.1002/ijc.27822;
RA   Pawlowski R., Muhl S.M., Sulser T., Krek W., Moch H., Schraml P.;
RT   "Loss of PBRM1 expression is associated with renal cell carcinoma
RT   progression.";
RL   Int. J. Cancer 132:E11-E17(2013).
//