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Cellosaurus TR146 (CVCL_2736)

[Text version]

Cell line name TR146
Synonyms Tr146; TR-146; TR 146
Accession CVCL_2736
Resource Identification Initiative To cite this cell line use: TR146 (RRID:CVCL_2736)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: MD Anderson Cell Lines Project.
Doubling time: 22 hours (PubMed=2413234).
Omics: Deep exome analysis.
Omics: Deep RNAseq analysis.
Omics: Protein expression by reverse-phase protein arrays.
Sequence variations
  • Mutation; HGNC; 1787; CDKN2A; Simple; p.Arg80Ter (c.237_238CC>TT) (c.237_238delinsTT) (p.Pro94Leu, c.280_281CC>TT); Zygosity=Homozygous (DepMap).
Disease Buccal mucosa squamous cell carcinoma (NCIt: C4040)
Squamous cell carcinoma of the oral cavity (ORDO: Orphanet_502363)
Derived from metastatic site: Cervical lymph node.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 67Y
Category Cancer cell line
STR profile Source(s): DepMap; ECACC; PubMed=21868764

Markers:
AmelogeninX
CSF1PO11,13
D3S135815
D5S81810,11
D7S82010,12
D8S117913
D13S31711,14
D16S53913
D18S5122
D21S1130,33.2
FGA21,23
Penta D10,12
Penta E13,17
TH016,9 (DepMap)
9 (ECACC; PubMed=21868764)
TPOX8,9
vWA15,18

Run an STR similarity search on this cell line
Web pages https://tcpaportal.org/mclp/
Publications

PubMed=2413234; DOI=10.1093/jnci/75.4.621
Rupniak H.T., Rowlatt C., Lane E.B., Steele J.G., Trejdosiewicz L.K., Laskiewicz B., Povey S., Hill B.T.
Characteristics of four new human cell lines derived from squamous cell carcinomas of the head and neck.
J. Natl. Cancer Inst. 75:621-635(1985)

DOI=10.1016/B978-0-12-333530-2.50007-1
Carey T.E.
Head and neck tumor cell lines.
(In) Atlas of human tumor cell lines; Hay R.J., Park J.-G., Gazdar A.F. (eds.); pp.79-120; Academic Press; New York (1994)

PubMed=21868764; DOI=10.1158/1078-0432.CCR-11-0690
Zhao M., Sano D., Pickering C.R., Jasser S.A., Henderson Y.C., Clayman G.L., Sturgis E.M., Ow T.J., Lotan R., Carey T.E., Sacks P.G., Grandis J.R., Sidransky D., Heldin N.-E., Myers J.N.
Assembly and initial characterization of a panel of 85 genomically validated cell lines from diverse head and neck tumor sites.
Clin. Cancer Res. 17:7248-7264(2011)

PubMed=26754630; DOI=10.1186/s13046-016-0284-4
Hyakusoku H., Sano D., Takahashi H., Hatano T., Isono Y., Shimada S., Ito Y., Myers J.N., Oridate N.
JunB promotes cell invasion, migration and distant metastasis of head and neck squamous cell carcinoma.
J. Exp. Clin. Cancer Res. 35:6.1-6.12(2016)

PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005
Li J., Zhao W., Akbani R., Liu W.-B., Ju Z.-L., Ling S.-Y., Vellano C.P., Roebuck P., Yu Q.-H., Eterovic A.K., Byers L.A., Davies M.A., Deng W.-L., Gopal Y.N.V., Chen G., von Euw E.M., Slamon D.J., Conklin D., Heymach J.V., Gazdar A.F., Minna J.D., Myers J.N., Lu Y.-L., Mills G.B., Liang H.
Characterization of human cancer cell lines by reverse-phase protein arrays.
Cancer Cell 31:225-239(2017)

PubMed=29156801; DOI=10.18632/oncotarget.21174
Kalu N.N., Mazumdar T., Peng S., Shen L., Sambandam V., Rao X., Xi Y., Li L., Qi Y., Gleber-Netto F.O., Patel A., Wang J., Frederick M.J., Myers J.N., Pickering C.R., Johnson F.M.
Genomic characterization of human papillomavirus-positive and -negative human squamous cell cancer cell lines.
Oncotarget 8:86369-86383(2017)

Cross-references
Cell line collections CancerTools; 151425
ECACC; 10032305
Ximbio; 151425
Cell line databases/resources DepMap; ACH-001675
Anatomy/cell type resources BTO; BTO:0002718
Encyclopedic resources Wikidata; Q54972930
Polymorphism and mutation databases Cosmic; 948039
Cosmic; 2131857
Entry history
Entry creation04-Apr-2012
Last entry update23-Jun-2022
Version number21