ID   UM-RC-6
AC   CVCL_2741
SY   UMRC-6; UMRC6; University of Michigan-Renal Carcinoma-6
DR   BioSample; SAMN03470958
DR   cancercelllines; CVCL_2741
DR   CancerTools; 160448
DR   Cell_Model_Passport; SIDM01829
DR   Cosmic; 972873
DR   Cosmic; 972913
DR   Cosmic; 1779196
DR   DepMap; ACH-001225
DR   ECACC; 08090513
DR   GEO; GSM374477
DR   PharmacoDB; UMRC6_1646_2019
DR   Progenetix; CVCL_2741
DR   Wikidata; Q54990787
DR   Ximbio; 160448
RX   PubMed=4038766;
RX   PubMed=7915601;
RX   PubMed=8493574;
RX   PubMed=25877200;
RX   PubMed=28489074;
RX   PubMed=30894373;
RX   PubMed=31068700;
WW   https://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/u/cell-lines-detail-317.html
CC   Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
CC   Population: African American.
CC   Doubling time: ~43 hours (PubMed=4038766).
CC   Sequence variation: Mutation; HGNC; 12687; VHL; Simple; p.Ser168Argfs*3 (c.504_511del); Zygosity=Unspecified (PubMed=7915601).
CC   Sequence variation: Mutation; HGNC; 12687; VHL; Simple; p.Val170Argfs*29 (c.502_511del10); Zygosity=Unspecified (PubMed=8493574).
CC   Genome ancestry: African=81.78%; Native American=0.05%; East Asian, North=2.02%; East Asian, South=0%; South Asian=0%; European, North=4.24%; European, South=11.91% (PubMed=30894373).
CC   Derived from site: In situ; Kidney; UBERON=UBERON_0002113.
ST   Source(s): ECACC; PubMed=25877200
ST   Amelogenin: X,Y
ST   CSF1PO: 8,12
ST   D13S317: 12
ST   D16S539: 9,10
ST   D18S51: 18
ST   D19S433: 14,18.2
ST   D21S11: 28
ST   D2S1338: 19,22
ST   D3S1358: 16
ST   D5S818: 12
ST   D7S820: 10,12
ST   D8S1179: 12,13
ST   FGA: 22
ST   Penta D: 7
ST   Penta E: 8
ST   TH01: 6
ST   TPOX: 10
ST   vWA: 18
DI   NCIt; C9385; Renal cell carcinoma
DI   ORDO; Orphanet_217071; Renal cell carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   Age unspecified
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 05-10-23; Version: 24
//
RX   PubMed=4038766; DOI=10.1002/jso.2930280320;
RA   Grossman H.B., Wedemeyer G., Ren L.-Q.;
RT   "Human renal carcinoma: characterization of five new cell lines.";
RL   J. Surg. Oncol. 28:237-244(1985).
//
RX   PubMed=7915601; DOI=10.1038/ng0594-85;
RA   Gnarra J.R., Tory K., Weng Y., Schmidt L.S., Wei M.H., Li H., Latif F.,
RA   Liu S., Chen F., Duh F.-M., Lubensky I.A., Duan D.R., Florence C.,
RA   Pozzatti R., Walther M.M., Bander N.H., Grossman H.B., Brauch H.,
RA   Pomer S., Brooks J.D., Isaacs W.B., Lerman M.I., Zbar B.,
RA   Linehan W.M.;
RT   "Mutations of the VHL tumour suppressor gene in renal carcinoma.";
RL   Nat. Genet. 7:85-90(1994).
//
RX   PubMed=8493574; DOI=10.1126/science.8493574;
RA   Latif F., Tory K., Gnarra J.R., Yao M., Duh F.-M., Orcutt M.L.,
RA   Stackhouse T., Kuzmin I.A., Modi W., Geil L., Schmidt L.S., Zhou F.-W.,
RA   Li H., Wei M.H., Chen F., Glenn G., Choyke P., Walther M.M., Weng Y.-K.,
RA   Duan D.-S.R., Dean M., Glavac D., Richards F.M., Crossey P.A.,
RA   Ferguson-Smith M.A., Le Paslier D., Chumakov I., Cohen D.,
RA   Chinault A.C., Maher E.R., Linehan W.M., Zbar B., Lerman M.I.;
RT   "Identification of the von Hippel-Lindau disease tumor suppressor
RT   gene.";
RL   Science 260:1317-1320(1993).
//
RX   PubMed=25877200; DOI=10.1038/nature14397;
RA   Yu M., Selvaraj S.K., Liang-Chu M.M.Y., Aghajani S., Busse M.,
RA   Yuan J., Lee G., Peale F.V., Klijn C., Bourgon R., Kaminker J.S.,
RA   Neve R.M.;
RT   "A resource for cell line authentication, annotation and quality
RT   control.";
RL   Nature 520:307-311(2015).
//
RX   PubMed=28489074; DOI=10.1038/ncomms15165;
RA   Sinha R., Winer A.G., Chevinsky M., Jakubowski C., Chen Y.-B., Dong Y.-Y.,
RA   Tickoo S.K., Reuter V.E., Russo P., Coleman J.A., Sander C.,
RA   Hsieh J.J.-D., Hakimi A.A.;
RT   "Analysis of renal cancer cell lines from two major resources enables
RT   genomics-guided cell line selection.";
RL   Nat. Commun. 8:15165.1-15165.10(2017).
//
RX   PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747;
RA   Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.;
RT   "An interactive resource to probe genetic diversity and estimated
RT   ancestry in cancer cell lines.";
RL   Cancer Res. 79:1263-1273(2019).
//
RX   PubMed=31068700; DOI=10.1038/s41586-019-1186-3;
RA   Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C.,
RA   McDonald E.R. III, Barretina J.G., Gelfand E.T., Bielski C.M., Li H.-X.,
RA   Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F.,
RA   Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R.,
RA   Lu Y.-L., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C.,
RA   Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A.,
RA   Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D.,
RA   Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L.,
RA   Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A.,
RA   Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D.,
RA   Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M.,
RA   Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R.,
RA   Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A.,
RA   Sellers W.R.;
RT   "Next-generation characterization of the Cancer Cell Line
RT   Encyclopedia.";
RL   Nature 569:503-508(2019).
//