ID   WIL2 NS
AC   CVCL_2761
SY   WIL2-NS; WIL-2NS; WIL-2-NS; WI-L2-NS; WI-L2 NS; WIL2NS; WIL2 Non-Secreting
DR   BTO; BTO:0001524
DR   CLO; CLO_0009601
DR   CLO; CLO_0009604
DR   CLDB; cl4717
DR   ArrayExpress; E-MTAB-3610
DR   ATCC; CRL-8155
DR   BioSample; SAMN03471196
DR   BioSample; SAMN03472416
DR   cancercelllines; CVCL_2761
DR   Cell_Model_Passport; SIDM01102
DR   ChEMBL-Cells; CHEMBL3308012
DR   ChEMBL-Targets; CHEMBL612810
DR   Cosmic-CLP; 1331049
DR   DepMap; ACH-002316
DR   ECACC; 90112121
DR   EGA; EGAS00001000978
DR   GDSC; 1331049
DR   GEO; GSM827461
DR   GEO; GSM1670575
DR   GEO; GSM4288411
DR   IARC_TP53; 4041
DR   IPD-IMGT/HLA; 11561
DR   JCRB; JCRB9063
DR   PharmacoDB; WIL2NS_1661_2019
DR   PRIDE; PXD030304
DR   Progenetix; CVCL_2761
DR   PubChem_Cell_line; CVCL_2761
DR   RCB; RCB2285
DR   TKG; TKG 0374
DR   Wikidata; Q54994065
RX   Patent=US4806476;
RX   PubMed=1677771;
RX   PubMed=7798274;
RX   PubMed=20215515;
RX   PubMed=27397505;
RX   PubMed=29892436;
RX   PubMed=30894373;
RX   PubMed=33198927;
RX   PubMed=35839778;
CC   Group: Hybridoma fusion partner cell line.
CC   Group: Patented cell line.
CC   Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
CC   Part of: COSMIC cell lines project.
CC   Registration: International Depositary Authority, American Type Culture Collection (ATCC); CRL-8155.
CC   Population: Caucasian.
CC   Characteristics: Does not secrete immunoglobulins.
CC   HLA typing: DPA1*02:02:02 (IPD-IMGT/HLA=11561).
CC   Microsatellite instability: Stable (MSS) (Sanger).
CC   Sequence variation: Mutation; HGNC; 11272; SPTA1; Simple; p.Ser1163Ala (c.3487T>G); ClinVar=VCV000258929; Zygosity=Homozygous (PubMed=33198927).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Met237Ile (c.711G>A); ClinVar=VCV000142714; Zygosity=Homozygous (PubMed=7798274; PubMed=33198927).
CC   Transformant: NCBI_TaxID; 10376; Epstein-Barr virus (EBV).
CC   Omics: Deep exome analysis.
CC   Omics: Deep quantitative proteome analysis.
CC   Omics: DNA methylation analysis.
CC   Omics: SNP array analysis.
CC   Omics: Transcriptome analysis by microarray.
CC   Genome ancestry: African=0%; Native American=0.61%; East Asian, North=0%; East Asian, South=0%; South Asian=1.47%; European, North=69.86%; European, South=28.06% (PubMed=30894373).
CC   Discontinued: RCB; RCB2285; true.
CC   Discontinued: TKG; TKG 0374; probable.
CC   Derived from site: In situ; Spleen; UBERON=UBERON_0002106.
ST   Source(s): ATCC; Cosmic-CLP; ECACC; JCRB; RCB
ST   Amelogenin: X,Y
ST   CSF1PO: 11,12
ST   D13S317: 11
ST   D16S539: 11,12
ST   D5S818: 12,13
ST   D7S820: 9,12
ST   F13A01: 6,7
ST   F13B: 10
ST   FESFPS: 11,12
ST   LPL: 9,10
ST   TH01: 8,9.3 (ATCC; Cosmic-CLP; ECACC; RCB)
ST   TH01: 8,10 (JCRB)
ST   TPOX: 8,11
ST   vWA: 17,20
DI   NCIt; C97074; Hereditary spherocytosis
DI   ORDO; Orphanet_822; Hereditary spherocytosis
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_6544 ! WIL2
SX   Male
AG   5Y
CA   Transformed cell line
DT   Created: 04-04-12; Last updated: 05-10-23; Version: 33
//
RX   Patent=US4806476;
RA   Coons T., Avner B.;
RT   "Efficient cell fusion process.";
RL   Patent number US4806476, 21-Feb-1989.
//
RX   PubMed=1677771; DOI=10.1073/pnas.88.15.6652;
RA   Benjamin M.B., Potter H., Yandell D.W., Little J.B.;
RT   "A system for assaying homologous recombination at the endogenous
RT   human thymidine kinase gene.";
RL   Proc. Natl. Acad. Sci. U.S.A. 88:6652-6656(1991).
//
RX   PubMed=7798274; DOI=10.1016/S0021-9258(18)31687-9;
RA   Carrier F., Smith M.L., Bae I., Kilpatrick K.E., Lansing T.J.,
RA   Chen C.-Y., Engelstein M., Friend S.H., Henner W.D., Gilmer T.M.,
RA   Kastan M.B., Fornace A.J. Jr.;
RT   "Characterization of human Gadd45, a p53-regulated protein.";
RL   J. Biol. Chem. 269:32672-32677(1994).
//
RX   PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458;
RA   Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P.,
RA   Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J.,
RA   Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C.,
RA   Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J.,
RA   Haber D.A.;
RT   "A genome-wide screen for microdeletions reveals disruption of
RT   polarity complex genes in diverse human cancers.";
RL   Cancer Res. 70:2158-2164(2010).
//
RX   PubMed=27397505; DOI=10.1016/j.cell.2016.06.017;
RA   Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P.,
RA   Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H.,
RA   Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H.,
RA   Deng X.-M., Egan R.K., Liu Q.-S., Mironenko T., Mitropoulos X.,
RA   Richardson L., Wang J.-H., Zhang T.-H., Moran S., Sayols S.,
RA   Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P.,
RA   Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H.,
RA   Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.;
RT   "A landscape of pharmacogenomic interactions in cancer.";
RL   Cell 166:740-754(2016).
//
RX   PubMed=29892436; DOI=10.1098/rsos.172472;
RA   Shioda S., Kasai F., Watanabe K., Kawakami K., Ohtani A., Iemura M.,
RA   Ozawa M., Arakawa A., Hirayama N., Kawaguchi E., Tano T., Miyata S.,
RA   Satoh M., Shimizu N., Kohara A.;
RT   "Screening for 15 pathogenic viruses in human cell lines registered at
RT   the JCRB Cell Bank: characterization of in vitro human cells by viral
RT   infection.";
RL   R. Soc. Open Sci. 5:172472-172472(2018).
//
RX   PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747;
RA   Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.;
RT   "An interactive resource to probe genetic diversity and estimated
RT   ancestry in cancer cell lines.";
RL   Cancer Res. 79:1263-1273(2019).
//
RX   PubMed=33198927; DOI=10.1016/j.mrgentox.2020.503236;
RA   Kasai F., Hirayama N., Kohara A.;
RT   "TK6 genome profile compared with WIL2-NS: reference data to improve
RT   the reproducibility of genotoxicity studies.";
RL   Mutat. Res. 858:503236.1-503236.7(2020).
//
RX   PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010;
RA   Goncalves E., Poulos R.C., Cai Z.-X., Barthorpe S., Manda S.S., Lucas N.,
RA   Beck A., Bucio-Noble D., Dausmann M., Hall C., Hecker M., Koh J.,
RA   Lightfoot H., Mahboob S., Mali I., Morris J., Richardson L.,
RA   Seneviratne A.J., Shepherd R., Sykes E., Thomas F., Valentini S.,
RA   Williams S.G., Wu Y.-X., Xavier D., MacKenzie K.L., Hains P.G., Tully B.,
RA   Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.;
RT   "Pan-cancer proteomic map of 949 human cell lines.";
RL   Cancer Cell 40:835-849.e8(2022).
//