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Cellosaurus HO-1-u-1 (CVCL_2784)

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Cell line name HO-1-u-1
Synonyms HO-1-U-1; Ho-1-u-1; HO1-U-1; HO1-U1; HO1U1; HO1u1; Ho1u1; Ueda-1
Accession CVCL_2784
Resource Identification Initiative To cite this cell line use: HO-1-u-1 (RRID:CVCL_2784)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: COSMIC cell lines project.
Population: Japanese.
Characteristics: Suitable for in vitro sublingual drug delivery screening involving passive diffusion (PubMed=17079100; PubMed=19071203).
Doubling time: ~23 hours (DOI=10.5794/jjoms.31.1347).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Deep exome analysis.
Omics: DNA methylation analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Misspelling: HO1-UI; In Cosmic 2546834.
Derived from sampling site: Salivary gland; sublingual gland.
Genome ancestry Source: PubMed=30894373

Origin% genome
Native American0
East Asian, North76.45
East Asian, South19.98
South Asian0.41
European, North1.61
European, South0
Disease Floor of mouth squamous cell carcinoma (NCIt: C4041)
Squamous cell carcinoma of the oral cavity (ORDO: Orphanet_502363)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 72Y
Category Cancer cell line
STR profile Source(s): Cosmic-CLP; JCRB; RCB; TKG


Run an STR similarity search on this cell line

Miyauchi S., Moroyama T., Sakamoto T., Okamoto T., Takada K.
Establishment of human tumor cell line (Ueda-1) derived from squamous cell carcinoma of the floor of the mouth.
Nihon Koku Geka Gakkai Zasshi 31:1347-1351(1985)

PubMed=9290701; DOI=10.1002/(SICI)1098-2744(199708)19:4<243::AID-MC5>3.0.CO;2-D
Jia L.-Q., Osada M., Ishioka C., Gamo M., Ikawa S., Suzuki T., Shimodaira H., Niitani T., Kudo T., Akiyama M., Kimura N., Matsuo M., Mizusawa H., Tanaka N., Koyama H., Namba M., Kanamaru R., Kuroki T.
Screening the p53 status of human cell lines using a yeast functional assay.
Mol. Carcinog. 19:243-253(1997)

PubMed=12738951; DOI=10.1067/moe.2003.36
Sugiyama M., Bhawal U.K., Dohmen T., Ono S., Miyauchi M., Ishikawa T.
Detection of human papillomavirus-16 and HPV-18 DNA in normal, dysplastic, and malignant oral epithelium.
Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod. 95:594-600(2003)

PubMed=17079100; DOI=10.1016/j.ijpharm.2006.10.012
Wang Y.-F., Zuo Z., Lee K.K.-H., Chow M.S.-S.
Evaluation of HO-1-u-1 cell line as an in vitro model for sublingual drug delivery involving passive diffusion -- Initial validation studies.
Int. J. Pharm. 334:27-34(2007)

PubMed=17325662; DOI=10.1038/sj.onc.1210330
Nakaya K., Yamagata H.D., Arita N., Nakashiro K.-I., Nose M., Miki T., Hamakawa H.
Identification of homozygous deletions of tumor suppressor gene FAT in oral cancer using CGH-array.
Oncogene 26:5300-5308(2007)

PubMed=19071203; DOI=10.1016/j.ijpharm.2008.11.010
Wang Y.-F., Zuo Z., Chow M.S.-S.
HO-1-u-1 model for screening sublingual drug delivery -- influence of pH, osmolarity and permeation enhancer.
Int. J. Pharm. 370:68-74(2009)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458
Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A.
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=25448555; DOI=10.1016/j.ijpharm.2014.11.040
Vacher G., Sublet E., Gurny R., Borchard G.
Establishment and first characterization of a sublingual epithelial and immune cell co-culture model.
Int. J. Pharm. 482:61-67(2015)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X.-M., Egan R.K., Liu Q.-S., Mironenko T., Mitropoulos X., Richardson L., Wang J.-H., Zhang T.-H., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

Cell line collections JCRB; JCRB0828
RCB; RCB2102
TKG; TKG 0455
Cell line databases/resources CLO; CLO_0051384
Cell_Model_Passport; SIDM00591
Cosmic-CLP; 753561
DepMap; ACH-002045
Anatomy/cell type resources BTO; BTO:0005948
Biological sample resources BioSample; SAMN01821683
BioSample; SAMN03472521
Chemistry resources GDSC; 753561
PharmacoDB; HO1u1_560_2019
Encyclopedic resources Wikidata; Q54890083
Gene expression databases ArrayExpress; E-MTAB-3610
GEO; GSM827216
GEO; GSM850381
GEO; GSM1669889
Polymorphism and mutation databases Cosmic; 753561
Cosmic; 1118792
Cosmic; 1120707
Cosmic; 1530742
Cosmic; 1571800
Cosmic; 1995441
Cosmic; 2266788
Cosmic; 2546834
Progenetix; CVCL_2784
Sequence databases EGA; EGAS00001000978
Entry history
Entry creation04-Apr-2012
Last entry update16-Dec-2021
Version number31