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Cellosaurus CMK-86 (CVCL_2804)

[Text version]

Cell line name CMK-86
Synonyms CMK86
Accession CVCL_2804
Resource Identification Initiative To cite this cell line use: CMK-86 (RRID:CVCL_2804)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Omics: SNP array analysis.
Derived from sampling site: Peripheral blood.
Sequence variations Has a TP53-FXR2 gene fusion (PubMed=16778363).
Heterozygous for TP53 p.Asp49His (c.145G>C) (from parent cell line).
Disease Down syndrome (NCIt: C2993)
Myeloid leukemia associated with Down syndrome (NCIt: C43223)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0216 (CMK)
Children:
CVCL_0217 (CMK-11-5)
Sex of cell Male
Age at sampling 10M
Category Cancer cell line
STR profile Source(s): JCRB

Markers:
AmelogeninX,Y
CSF1PO11,13
D5S81811,12
D7S82011,12
D13S31711
D16S5399,11
TH017
TPOX9,11
vWA18
Publications

PubMed=16778363; DOI=10.1620/tjem.209.169
Kanezaki R., Toki T., Xu G., Narayanan R., Ito E.
Cloning and characterization of the novel chimeric gene p53/FXR2 in the acute megakaryoblastic leukemia cell line CMK11-5.
Tohoku J. Exp. Med. 209:169-180(2006)

PubMed=22460905; DOI=10.1038/nature11003
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.K., Yu J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=23955599; DOI=10.1038/ng.2731
Kon A., Shih L.-Y., Minamino M., Sanada M., Shiraishi Y., Nagata Y., Yoshida K., Okuno Y., Bando M., Nakato R., Ishikawa S., Sato-Otsubo A., Nagae G., Nishimoto A., Haferlach C., Nowak D., Sato Y., Alpermann T., Nagasaki M., Shimamura T., Tanaka H., Chiba K., Yamamoto R., Yamaguchi T., Otsu M., Obara N., Sakata-Yanagimoto M., Nakamaki T., Ishiyama K., Nolte F., Hofmann W.K., Miyawaki S., Chiba S., Mori H., Nakauchi H., Koeffler H.P., Aburatani H., Haferlach T., Shirahige K., Miyano S., Ogawa S.
Recurrent mutations in multiple components of the cohesin complex in myeloid neoplasms.
Nat. Genet. 45:1232-1237(2013)

Cross-references
Cell line collections JCRB; IFO50428
Cell line databases/resources CCLE; CMK86_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE
Ontologies BTO; BTO:0004960
Gene expression databases GEO; GSM888004
Other Wikidata; Q54813774
Polymorphism and mutation databases Cosmic; 2089670