ID   JHH-7
AC   CVCL_2805
SY   Jhh-7; JHH7; FLC-7; FLC7; Functional Liver Cell-7
DR   EFO; EFO_0006603
DR   ArrayExpress; E-MTAB-2706
DR   ArrayExpress; E-MTAB-2770
DR   ArrayExpress; E-MTAB-3610
DR   BioSample; SAMN03471923
DR   CCLE; JHH7_LIVER
DR   Cell_Model_Passport; SIDM00614
DR   Cosmic; 1187336
DR   Cosmic; 1995464
DR   Cosmic; 2023877
DR   Cosmic-CLP; 1240160
DR   GDSC; 1240160
DR   GEO; GSM887174
DR   GEO; GSM888246
DR   GEO; GSM936769
DR   GEO; GSM1669954
DR   JCRB; JCRB1031
DR   JCRB; NIHS0281
DR   LINCS_LDP; LCL-1931
DR   PRIDE; PXD002486
DR   Wikidata; Q54898645
RX   PubMed=1701409;
RX   PubMed=1707654;
RX   PubMed=9359923;
RX   PubMed=10523694;
RX   PubMed=10933057;
RX   PubMed=17241388;
RX   PubMed=22460905;
RX   PubMed=23505090;
RX   PubMed=25485619;
RX   PubMed=27397505;
RX   PubMed=28196595;
RX   PubMed=29892436;
RX   PubMed=30894373;
WW   http://tcpaportal.org/mclp/
CC   Part of: Cancer Cell Line Encyclopedia (CCLE) project.
CC   Part of: COSMIC cell lines project.
CC   Part of: MD Anderson Cell Lines Project.
CC   Characteristics: Contains 2 copies of integrated incomplete HBV genomes. Does not secrete hepatitis virus B surface antigen (HBsAg) (PubMed=1701409).
CC   Doubling time: ~29 hours (lot 10312012), 30 hours (lot 06252008), ~26 hours (lot 01182016) (JCRB).
CC   Microsatellite instability: Stable (MSS) (Sanger).
CC   Transformant: NCBI_TaxID; 10407; Hepatitis B virus (HBV).
CC   Omics: Deep exome analysis.
CC   Omics: Deep RNAseq analysis.
CC   Omics: DNA methylation analysis.
CC   Omics: Protein expression by reverse-phase protein arrays.
CC   Omics: SNP array analysis.
CC   Omics: Transcriptome analysis.
CC   Genome ancestry: African=0%; Native American=0%; East Asian, North=86.04%; East Asian, South=12.59%; South Asian=1.36%; European, North=0%; European, South=0% (PubMed=30894373).
CC   Discontinued: JCRB; NIHS0281; true.
ST   Source(s): Cosmic-CLP; JCRB; PubMed=25877200
ST   Amelogenin: X,Y
ST   CSF1PO: 13,14
ST   D13S317: 12
ST   D16S539: 13
ST   D18S51: 17
ST   D21S11: 29,33.2
ST   D3S1358: 15,17
ST   D5S818: 13
ST   D7S820: 8,11
ST   D8S1179: 10,11
ST   FGA: 22
ST   Penta D: 12
ST   Penta E: 10,11
ST   TH01: 6
ST   TPOX: 9,11
ST   vWA: 16,18
DI   NCIt; C3099; Hepatocellular carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens
SX   Male
AG   53Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 24-05-19; Version: 22
//
RX   PubMed=1701409;
RA   Fujise K., Nagamori S., Hasumura S., Homma S., Sujino H., Matsuura T.,
RA   Shimizu K., Niiya M., Kameda H., Fujita K., Ohno T.;
RT   "Integration of hepatitis B virus DNA into cells of six established
RT   human hepatocellular carcinoma cell lines.";
RL   Hepato-Gastroenterol. 37:457-460(1990).
//
RX   PubMed=1707654;
RA   Homma S., Nagamori S., Fujise K., Hasumura S., Sujino H., Matsuura T.,
RA   Shimizu K., Niiya M., Kameda H.;
RT   "Establishment and characterization of a human hepatocellular
RT   carcinoma cell line JHH-7 producing alpha -fetoprotein and
RT   carcinoembryonic antigen -- changes in secretion of AFP and CEA from
RT   JHH-7 cells after heat treatment.";
RL   Hum. Cell 3:152-157(1990).
//
RX   PubMed=9359923; DOI=10.18926/AMO/30789;
RA   Mihara K., Miyazaki M., Kondo T., Fushimi K., Tsuji T., Inoue Y.,
RA   Fukaya K.-I., Ishioka C., Namba M.;
RT   "Yeast functional assay of the p53 gene status in human cell lines
RT   maintained in our laboratory.";
RL   Acta Med. Okayama 51:261-265(1997).
//
RX   PubMed=10523694; DOI=10.3892/or.6.6.1267;
RA   Gao C., Ohashi R., Pu H., Inoue Y., Tsuji T., Miyazaki M., Namba M.;
RT   "Yeast functional assay of the p53 gene status in 11 cell lines and 26
RT   surgical specimens of human hepatocellular carcinoma.";
RL   Oncol. Rep. 6:1267-1271(1999).
//
RX   PubMed=10933057; DOI=10.1038/sj.neo.7900046;
RA   Murakami K., Sakukawa R., Ikeda T., Matsuura T., Hasumura S.,
RA   Nagamori S., Yamada Y., Saiki I.;
RT   "Invasiveness of hepatocellular carcinoma cell lines: contribution of
RT   membrane-type 1 matrix metalloproteinase.";
RL   Neoplasia 1:424-430(1999).
//
RX   PubMed=17241388; DOI=10.1111/j.1478-3231.2006.01410.x;
RA   Kosuge M., Takizawa H., Maehashi H., Matsuura T., Matsufuji S.;
RT   "A comprehensive gene expression analysis of human hepatocellular
RT   carcinoma cell lines as components of a bioartificial liver using a
RT   radial flow bioreactor.";
RL   Liver Int. 27:101-108(2007).
//
RX   PubMed=22460905; DOI=10.1038/nature11003;
RA   Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A.,
RA   Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A.,
RA   Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J.,
RA   Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E.,
RA   Raman P., Shipway A., Engels I.H., Cheng J., Yu G.K., Yu J.,
RA   Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C.,
RA   Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C.,
RA   Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N., Mesirov J.P.,
RA   Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L.,
RA   Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M., Golub T.R.,
RA   Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.;
RT   "The Cancer Cell Line Encyclopedia enables predictive modelling of
RT   anticancer drug sensitivity.";
RL   Nature 483:603-607(2012).
//
RX   PubMed=23505090; DOI=10.1002/hep.26402;
RA   Wang K., Lim H.Y., Shi S., Lee J., Deng S., Xie T., Zhu Z., Wang Y.,
RA   Pocalyko D., Yang W.J., Rejto P.A., Mao M., Park C.-K., Xu J.;
RT   "Genomic landscape of copy number aberrations enables the
RT   identification of oncogenic drivers in hepatocellular carcinoma.";
RL   Hepatology 58:706-717(2013).
//
RX   PubMed=25485619; DOI=10.1038/nbt.3080;
RA   Klijn C., Durinck S., Stawiski E.W., Haverty P.M., Jiang Z., Liu H.,
RA   Degenhardt J., Mayba O., Gnad F., Liu J., Pau G., Reeder J., Cao Y.,
RA   Mukhyala K., Selvaraj S.K., Yu M., Zynda G.J., Brauer M.J., Wu T.D.,
RA   Gentleman R.C., Manning G., Yauch R.L., Bourgon R., Stokoe D.,
RA   Modrusan Z., Neve R.M., de Sauvage F.J., Settleman J., Seshagiri S.,
RA   Zhang Z.;
RT   "A comprehensive transcriptional portrait of human cancer cell
RT   lines.";
RL   Nat. Biotechnol. 33:306-312(2015).
//
RX   PubMed=27397505; DOI=10.1016/j.cell.2016.06.017;
RA   Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P.,
RA   Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H.,
RA   Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H.,
RA   Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X.,
RA   Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M.,
RA   Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M.,
RA   Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A.,
RA   Saez-Rodriguez J., McDermott U., Garnett M.J.;
RT   "A landscape of pharmacogenomic interactions in cancer.";
RL   Cell 166:740-754(2016).
//
RX   PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005;
RA   Li J., Zhao W., Akbani R., Liu W., Ju Z., Ling S., Vellano C.P.,
RA   Roebuck P., Yu Q., Eterovic A.K., Byers L.A., Davies M.A., Deng W.,
RA   Gopal Y.N.V., Chen G., von Euw E.M., Slamon D.J., Conklin D.,
RA   Heymach J.V., Gazdar A.F., Minna J.D., Myers J.N., Lu Y., Mills G.B.,
RA   Liang H.;
RT   "Characterization of human cancer cell lines by reverse-phase protein
RT   arrays.";
RL   Cancer Cell 31:225-239(2017).
//
RX   PubMed=29892436; DOI=10.1098/rsos.172472;
RA   Shioda S., Kasai F., Watanabe K., Kawakami K., Ohtani A., Iemura M.,
RA   Ozawa M., Arakawa A., Hirayama N., Kawaguchi E., Tano T., Miyata S.,
RA   Satoh M., Shimizu N., Kohara A.;
RT   "Screening for 15 pathogenic viruses in human cell lines registered at
RT   the JCRB Cell Bank: characterization of in vitro human cells by viral
RT   infection.";
RL   R. Soc. Open Sci. 5:172472-172472(2018).
//
RX   PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747;
RA   Dutil J., Chen Z., Monteiro A.N., Teer J.K., Eschrich S.A.;
RT   "An interactive resource to probe genetic diversity and estimated
RT   ancestry in cancer cell lines.";
RL   Cancer Res. 79:1263-1273(2019).
//