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Cellosaurus YMB-1 (CVCL_2814)

[Text version]

Cell line name YMB-1
Synonyms YMB1
Accession CVCL_2814
Resource Identification Initiative To cite this cell line use: YMB-1 (RRID:CVCL_2814)
Comments Problematic cell line: Contaminated. Shown to be a ZR-75-1 derivative (PubMed=23136038). Originally thought to originate from the primary breast carcinoma tissue of a 55 year old woman patient.
Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00391.
Doubling time: 44 hours (PubMed=6534930).
Omics: Deep RNAseq analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Sequence variations Homozygous for HRAS p.Glu162Lys (c.484G>A) (from parent cell line).
Homozygous for PTEN p.Leu108Arg (c.323T>G) (from parent cell line).
Has no TP53 mutation (PubMed=15900046).
Genome ancestry Source: PubMed=30894373

Origin% genome
African1.26
Native American0
East Asian, North3.7
East Asian, South0
South Asian0
European, North57.42
European, South37.62
Disease Invasive ductal carcinoma, not otherwise specified (NCIt: C4194)
Derived from metastatic site: Ascites.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0588 (ZR-75-1)
Children:
CVCL_B372 (YMB-1-C)CVCL_2815 (YMB-1-E)CVCL_0586 (YMB-A)
CVCL_D103 (YMB-S)
Sex of cell Female
Age at sampling 63Y
Category Cancer cell line
STR profile Source(s): JCRB

Markers:
AmelogeninX
CSF1PO10,11
D5S81813
D7S82010,11
D13S3179
D16S53911
TH017,9.3
TPOX8
vWA16,18

Run an STR similarity search on this cell line
Web pages http://iclac.org/wp-content/uploads/Cross-Contaminations_v10_distribution.xlsx
Publications

PubMed=6534930
Yamane M., Nishiki M., Kataoka T., Kishi N., Amano K., Nakagawa K., Okumichi T., Naito M., Ito A., Ezaki H.
Establishment and characterization of new cell line (YMB-1) derived from human breast carcinoma.
Hiroshima J. Med. Sci. 33:715-720(1984)

DOI=10.1016/B978-0-12-333530-2.50009-5
Leibovitz A.
Cell lines from human breast.
(In) Atlas of human tumor cell lines; Hay R.J., Park J.-G., Gazdar A.F. (eds.); pp.161-184; Academic Press; New York (1994)

PubMed=9290701; DOI=10.1002/(SICI)1098-2744(199708)19:4<243::AID-MC5>3.0.CO;2-D
Jia L.-Q., Osada M., Ishioka C., Gamo M., Ikawa S., Suzuki T., Shimodaira H., Niitani T., Kudo T., Akiyama M., Kimura N., Matsuo M., Mizusawa H., Tanaka N., Koyama H., Namba M., Kanamaru R., Kuroki T.
Screening the p53 status of human cell lines using a yeast functional assay.
Mol. Carcinog. 19:243-253(1997)

PubMed=15900046; DOI=10.1093/jnci/dji133
Mashima T., Oh-hara T., Sato S., Mochizuki M., Sugimoto Y., Yamazaki K., Hamada J., Tada M., Moriuchi T., Ishikawa Y., Kato Y., Tomoda H., Yamori T., Tsuruo T.
p53-defective tumors with a functional apoptosome-mediated pathway: a new therapeutic target.
J. Natl. Cancer Inst. 97:765-777(2005)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458
Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A.
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=22460905; DOI=10.1038/nature11003
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.K., Yu J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=23136038; DOI=10.1002/ijc.27931
Capes-Davis A., Reid Y.A., Kline M.C., Storts D.R., Strauss E., Dirks W.G., Drexler H.G., MacLeod R.A.F., Sykes G., Kohara A., Nakamura Y., Elmore E., Nims R.W., Alston-Roberts C., Barallon R., Los G.V., Nardone R.M., Price P.J., Steuer A., Thomson J., Masters J.R.W., Kerrigan L.
Match criteria for human cell line authentication: where do we draw the line?
Int. J. Cancer 132:2510-2519(2013)

PubMed=25485619; DOI=10.1038/nbt.3080
Klijn C., Durinck S., Stawiski E.W., Haverty P.M., Jiang Z., Liu H., Degenhardt J., Mayba O., Gnad F., Liu J., Pau G., Reeder J., Cao Y., Mukhyala K., Selvaraj S.K., Yu M., Zynda G.J., Brauer M.J., Wu T.D., Gentleman R.C., Manning G., Yauch R.L., Bourgon R., Stokoe D., Modrusan Z., Neve R.M., de Sauvage F.J., Settleman J., Seshagiri S., Zhang Z.
A comprehensive transcriptional portrait of human cancer cell lines.
Nat. Biotechnol. 33:306-312(2015)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z., Monteiro A.N., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3
Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. III, Barretina J., Gelfand E.T., Bielski C.M., Li H., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R.
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

Cross-references
Cell line collections JCRB; JCRB0823
Cell line databases/resources CCLE; YMB1_BREAST
Cell_Model_Passport; SIDM01260
DepMap; ACH-001249
LINCS_LDP; LCL-1488
Ontologies BTO; BTO:0002404
EFO; EFO_0006779
Biological sample resources BioSample; SAMN03152042
Chemistry resources PharmacoDB; YMB1_1686_2019
Gene expression databases ArrayExpress; E-MTAB-2706
GEO; GSM827238
GEO; GSM887749
GEO; GSM888844
Other Wikidata; Q54995442
Polymorphism and mutation databases IARC_TP53; 30191
Entry history
Entry creation04-Apr-2012
Last entry update02-Jul-2020
Version number26