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Cellosaurus 3A(tPA-30-1) (CVCL_2820)

[Text version]
Cell line name 3A(tPA-30-1)
Synonyms TPA30-1; TPA 30-1; tPA30-1
Accession CVCL_2820
Resource Identification Initiative To cite this cell line use: 3A(tPA-30-1) (RRID:CVCL_2820)
Comments Characteristics: Expresses the transformed phenotype at the permissive temperature (33 Celsius) and the non-transformed phenotype at the restrictive temperature (40 Celsius).
Senescence: Has a limited life expectancy of 15 to 18 passages before entering the crisis stage (ATCC=CRL-1583).
Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40) [Note=ts30].
Derived from site: In situ; Placenta; UBERON=UBERON_0001987.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_2287 (3A sub E)
Originate from same individual CVCL_H646 ! TPA30-6
CVCL_H645 ! TPWT-2
Sex of cell Female
Category Transformed cell line
STR profile Source(s): ATCC=CRL-1583

Markers:
AmelogeninX
CSF1PO10,12
D2S133820,22
D3S135814,15
D5S81811,13
D7S82010
D8S117913,14
D13S31711
D16S5399,12
D18S5112,20
D19S43314,16.2
D21S1128,29
FGA21,25
Penta D8,9
Penta E7,14
TH019,9.3
TPOX8,11
vWA16,17

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Publications

PubMed=206898; DOI=10.1073/pnas.75.3.1409
Chou J.Y.
Human placental cells transformed by tsA mutants of simian virus 40: a model system for the study of placental functions.
Proc. Natl. Acad. Sci. U.S.A. 75:1409-1413(1978)

PubMed=3493529; DOI=10.1126/science.3493529
Wong G.G., Temple P.A., Leary A.C., Witek-Giannotti J.S., Yang Y.-C., Brennan A., Chung M., Murtha P., Kriz R., Kaufman R.J., Ferenz C.R., Sibley B.S., Turner K.J., Hewick R.M., Clark S.C., Yanai N., Yokota H., Yamada M., Saito M., Motoyoshi K., Takaku F.
Human CSF-1: molecular cloning and expression of 4-kb cDNA encoding the human urinary protein.
Science 235:1504-1508(1987)

PubMed=33043158; DOI=10.1016/j.heliyon.2020.e04759
Ono A., Benny P., Griffith M., Litton C., Lee M.-J.
Appropriate citation of placenta cell lines 3A(tPA-30-1) and 3A-sub E [post crisis of 3A(tPA-30-1)] in medical literature.
Heliyon 6:e04759.1-e04759.9(2020)

Cross-references
Cell line collections (Providers) ATCC; CRL-1583
ECACC; 96020926
Cell line databases/resources CLO; CLO_0001325
Biological sample resources BioSample; SAMN03471399
Encyclopedic resources Wikidata; Q54585261
Entry history
Entry creation04-Apr-2012
Last entry update02-May-2024
Version number16