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Cellosaurus ASH-3 (CVCL_2856)

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Cell line name ASH-3
Synonyms ASH3
Accession CVCL_2856
Resource Identification Initiative To cite this cell line use: ASH-3 (RRID:CVCL_2856)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Part of: COSMIC cell lines project.
Doubling time: 84 hours (PubMed=11686581).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Deep exome analysis.
Omics: DNA methylation analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Sequence variations NRAS p.Gln61Lys (c.181C>A) (PubMed=23833040).
Heterozygous for NRAS p.Gln61Arg (c.181A>G) (PubMed=30737244).
Homozygous for PTEN p.Phe241fs (c.724dupG) (PubMed=30737244).
Heterozygous for TERT c.250C>T (-146C>T); in promoter (PubMed=23833040; PubMed=30737244).
Homozygous for TP53 p.His179Arg (c.536A>G) (PubMed=30737244).
Genome ancestry Source: PubMed=30894373

Origin% genome
African0
Native American0.08
East Asian, North79.16
East Asian, South20.41
South Asian0.34
European, North0
European, South0
Disease Thyroid gland undifferentiated (anaplastic) carcinoma (NCIt: C3878)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 68Y
Category Cancer cell line
STR profile Source(s): Cosmic-CLP; JCRB; PubMed=25877200; PubMed=30737244

Markers:
AmelogeninX
CSF1PO10,14
D2S133819,23
D3S135815
D5S81811,13
D7S82011
D8S117916
D13S31712
D16S5399
D18S5113,17
D19S43313,15.2
D21S1128
FGA20,22
Penta D10,11
Penta E5
TH019
TPOX8,11
vWA16,17

Run an STR similarity search on this cell line
Publications

PubMed=11686581; DOI=10.1016/S0753-3322(01)00087-7
Sekiguchi M., Shiroko Y., Arai T., Kishino T., Sugawara I., Kusakabe T., Suzuki T., Yamashita T., Obara T., Ito K., Hasumi K.
Biological characteristics and chemosensitivity profile of four human anaplastic thyroid carcinoma cell lines.
Biomed. Pharmacother. 55:466-474(2001)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458
Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A.
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=23833040; DOI=10.1210/jc.2013-2383
Landa I., Ganly I., Chan T.A., Mitsutake N., Matsuse M., Ibrahimpasic T., Ghossein R.A., Fagin J.A.
Frequent somatic TERT promoter mutations in thyroid cancer: higher prevalence in advanced forms of the disease.
J. Clin. Endocrinol. Metab. 98:E1562-E1566(2013)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=30737244; DOI=10.1158/1078-0432.CCR-18-2953
Landa I., Pozdeyev N., Korch C., Marlow L.A., Smallridge R.C., Copland J.A., Henderson Y.C., Lai S.Y., Clayman G.L., Onoda N., Tan A.C., Garcia-Rendueles M.E.R., Knauf J.A., Haugen B.R., Fagin J.A., Schweppe R.E.
Comprehensive genetic characterization of human thyroid cancer cell lines: a validated panel for preclinical studies.
Clin. Cancer Res. 25:3141-3151(2019)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z., Monteiro A.N., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

Cross-references
Cell line collections JCRB; JCRB1073
JCRB; NIHS0269 - Discontinued
Cell line databases/resources CCLE; ASH3_THYROID
Cell_Model_Passport; SIDM00491
Cosmic-CLP; 1290722
DepMap; ACH-001443
GDSC; 1290722
LINCS_LDP; LCL-1682
Biological sample resources BioSample; SAMN03470933
Chemistry resources PharmacoDB; ASH3_65_2019
Gene expression databases ArrayExpress; E-MTAB-3610
GEO; GSM827189
GEO; GSM1669602
Other Wikidata; Q54750715
Polymorphism and mutation databases Cosmic; 2054110
Entry history
Entry creation04-Apr-2012
Last entry updated06-Sep-2019
Version number22