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Cellosaurus AZ-521 (CVCL_2862)

[Text version]

Cell line name AZ-521
Synonyms AZ 521; AZ521
Accession CVCL_2862
Resource Identification Initiative To cite this cell line use: AZ-521 (RRID:CVCL_2862)
Comments Problematic cell line: Contaminated. Shown to be a Hutu 80 derivative (see JCRB web site).
Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Part of: JFCR45 cancer cell line panel.
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00369.
Doubling time: ~30 hours (lot 11162006) (JCRB).
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Sequence variations Heterozygous for CTNNB1 p.Ser37Phe (c.110C>T) (ClinVar=VCV000017586) (from parent cell line).
Has no TP53 mutation (PubMed=1370612).
Genome ancestry Source: PubMed=30894373

Origin% genome
African78.39
Native American0
East Asian, North1.7
East Asian, South0
South Asian0.23
European, North10.56
European, South9.12
Disease Duodenal adenocarcinoma (NCIt: C7889)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1301 (HuTu 80)
Children:
CVCL_9480 (AZ-H3c)CVCL_9479 (AZ-H6c)
Sex of cell Male
Age at sampling 53Y
Category Cancer cell line
STR profile Source(s): JCRB; RCB; TKG

Markers:
AmelogeninX,Y
CSF1PO11,13
D5S81812,13
D7S8209,11
D13S3178,11
D16S53910,11
TH017
TPOX9,11
vWA16,18

Run an STR similarity search on this cell line
Web pages http://iclac.org/wp-content/uploads/Cross-Contaminations_v10_distribution.xlsx
https://cell.brc.riken.jp/en/announcement/az521
Publications

PubMed=1370612; DOI=10.1016/S0006-291X(05)80133-0
Matozaki T., Sakamoto C., Matsuda K., Suzuki T., Konda Y., Nakano O., Wada K., Uchida T., Nishisaki H., Nagao M., Kasuga M.
Missense mutations and a deletion of the p53 gene in human gastric cancer.
Biochem. Biophys. Res. Commun. 182:215-223(1992)

PubMed=15723654; DOI=10.1111/j.1349-7006.2005.00016.x
Takada H., Imoto I., Tsuda H., Sonoda I., Ichikura T., Mochizuki H., Okanoue T., Inazawa J.
Screening of DNA copy-number aberrations in gastric cancer cell lines by array-based comparative genomic hybridization.
Cancer Sci. 96:100-110(2005)

PubMed=15767549; DOI=10.1158/1535-7163.MCT-04-0234
Nakatsu N., Yoshida Y., Yamazaki K., Nakamura T., Dan S., Fukui Y., Yamori T.
Chemosensitivity profile of cancer cell lines and identification of genes determining chemosensitivity by an integrated bioinformatical approach using cDNA arrays.
Mol. Cancer Ther. 4:399-412(2005)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458
Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A.
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=22460905; DOI=10.1038/nature11003
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.K., Yu J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z., Monteiro A.N., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3
Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. III, Barretina J., Gelfand E.T., Bielski C.M., Li H., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R.
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

Cross-references
Cell line collections JCRB; JCRB0061
RCB; RCB2087 - Discontinued
TKG; TKG 0185
Cell line databases/resources CCLE; AZ521_SMALL_INTESTINE
CGH-DB; 136-1
DepMap; ACH-001015
LINCS_LDP; LCL-1533
Ontologies CLO; CLO_0050792
EFO; EFO_0002814
Biological sample resources BioSample; SAMN03151798
Chemistry resources ChEMBL-Cells; CHEMBL3307904
ChEMBL-Targets; CHEMBL614274
PharmacoDB; AZ521_72_2019
Gene expression databases GEO; GSM552355
GEO; GSM562393
GEO; GSM827401
GEO; GSM843443
GEO; GSM886872
GEO; GSM887937
GEO; GSM1374397
Other Wikidata; Q54752018
Polymorphism and mutation databases Cosmic; 877047
Cosmic; 889108
Cosmic; 918495
Cosmic; 1066228
Cosmic; 1077281
Cosmic; 1187267
Cosmic; 1482080
Cosmic; 1518246
Cosmic; 2484969
IARC_TP53; 21179
Entry history
Entry creation04-Apr-2012
Last entry update02-Jul-2020
Version number25