ID   AZ-521
AC   CVCL_2862
SY   AZ 521; AZ521
DR   CLO; CLO_0050792
DR   EFO; EFO_0002814
DR   BioSample; SAMN03151798
DR   CCLE; AZ521_SMALL_INTESTINE
DR   CGH-DB; 136-1
DR   ChEMBL-Cells; CHEMBL3307904
DR   ChEMBL-Targets; CHEMBL614274
DR   Cosmic; 877047
DR   Cosmic; 889108
DR   Cosmic; 918495
DR   Cosmic; 1066228
DR   Cosmic; 1077281
DR   Cosmic; 1187267
DR   Cosmic; 1482080
DR   Cosmic; 1518246
DR   Cosmic; 2484969
DR   DepMap; ACH-001015
DR   GEO; GSM552355
DR   GEO; GSM562393
DR   GEO; GSM827401
DR   GEO; GSM843443
DR   GEO; GSM886872
DR   GEO; GSM887937
DR   GEO; GSM1374397
DR   IARC_TP53; 21179
DR   JCRB; JCRB0061
DR   LINCS_LDP; LCL-1533
DR   PharmacoDB; AZ521_72_2019
DR   RCB; RCB2087
DR   TKG; TKG 0185
DR   Wikidata; Q54752018
RX   PubMed=1370612;
RX   PubMed=15723654;
RX   PubMed=15767549;
RX   PubMed=20215515;
RX   PubMed=22460905;
RX   PubMed=30894373;
RX   PubMed=31068700;
WW   http://iclac.org/wp-content/uploads/Cross-Contaminations_v10_distribution.xlsx
WW   https://cell.brc.riken.jp/en/announcement/az521
CC   Problematic cell line: Contaminated. Shown to be a Hutu 80 derivative (see JCRB web site).
CC   Part of: Cancer Cell Line Encyclopedia (CCLE) project.
CC   Part of: JFCR45 cancer cell line panel.
CC   Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00369.
CC   Doubling time: ~30 hours (lot 11162006) (JCRB).
CC   Sequence variation: Heterozygous for CTNNB1 p.Ser37Phe (c.110C>T) (ClinVar=VCV000017586) (from parent cell line).
CC   Sequence variation: Has no TP53 mutation (PubMed=1370612).
CC   Omics: SNP array analysis.
CC   Omics: Transcriptome analysis.
CC   Genome ancestry: African=78.39%; Native American=0%; East Asian, North=1.7%; East Asian, South=0%; South Asian=0.23%; European, North=10.56%; European, South=9.12% (PubMed=30894373).
CC   Discontinued: RCB; RCB2087; true.
ST   Source(s): JCRB; RCB; TKG
ST   Amelogenin: X,Y
ST   CSF1PO: 11,13
ST   D13S317: 8,11
ST   D16S539: 10,11
ST   D5S818: 12,13
ST   D7S820: 9,11
ST   TH01: 7
ST   TPOX: 9,11
ST   vWA: 16,18
DI   NCIt; C7889; Duodenal adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens
HI   CVCL_1301 ! HuTu 80
SX   Male
AG   53Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 02-07-20; Version: 25
//
RX   PubMed=1370612; DOI=10.1016/S0006-291X(05)80133-0;
RA   Matozaki T., Sakamoto C., Matsuda K., Suzuki T., Konda Y., Nakano O.,
RA   Wada K., Uchida T., Nishisaki H., Nagao M., Kasuga M.;
RT   "Missense mutations and a deletion of the p53 gene in human gastric
RT   cancer.";
RL   Biochem. Biophys. Res. Commun. 182:215-223(1992).
//
RX   PubMed=15723654; DOI=10.1111/j.1349-7006.2005.00016.x;
RA   Takada H., Imoto I., Tsuda H., Sonoda I., Ichikura T., Mochizuki H.,
RA   Okanoue T., Inazawa J.;
RT   "Screening of DNA copy-number aberrations in gastric cancer cell lines
RT   by array-based comparative genomic hybridization.";
RL   Cancer Sci. 96:100-110(2005).
//
RX   PubMed=15767549; DOI=10.1158/1535-7163.MCT-04-0234;
RA   Nakatsu N., Yoshida Y., Yamazaki K., Nakamura T., Dan S., Fukui Y.,
RA   Yamori T.;
RT   "Chemosensitivity profile of cancer cell lines and identification of
RT   genes determining chemosensitivity by an integrated bioinformatical
RT   approach using cDNA arrays.";
RL   Mol. Cancer Ther. 4:399-412(2005).
//
RX   PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458;
RA   Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P.,
RA   Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J.,
RA   Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C.,
RA   Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J.,
RA   Haber D.A.;
RT   "A genome-wide screen for microdeletions reveals disruption of
RT   polarity complex genes in diverse human cancers.";
RL   Cancer Res. 70:2158-2164(2010).
//
RX   PubMed=22460905; DOI=10.1038/nature11003;
RA   Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A.,
RA   Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A.,
RA   Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J.,
RA   Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E.,
RA   Raman P., Shipway A., Engels I.H., Cheng J., Yu G.K., Yu J.,
RA   Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C.,
RA   Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C.,
RA   Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N., Mesirov J.P.,
RA   Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L.,
RA   Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M., Golub T.R.,
RA   Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.;
RT   "The Cancer Cell Line Encyclopedia enables predictive modelling of
RT   anticancer drug sensitivity.";
RL   Nature 483:603-607(2012).
//
RX   PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747;
RA   Dutil J., Chen Z., Monteiro A.N., Teer J.K., Eschrich S.A.;
RT   "An interactive resource to probe genetic diversity and estimated
RT   ancestry in cancer cell lines.";
RL   Cancer Res. 79:1263-1273(2019).
//
RX   PubMed=31068700; DOI=10.1038/s41586-019-1186-3;
RA   Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C.,
RA   McDonald E.R. III, Barretina J., Gelfand E.T., Bielski C.M., Li H.,
RA   Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F.,
RA   Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R.,
RA   Lu Y., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C.,
RA   Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A.,
RA   Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D.,
RA   Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L.,
RA   Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A.,
RA   Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D.,
RA   Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M.,
RA   Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R.,
RA   Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A.,
RA   Sellers W.R.;
RT   "Next-generation characterization of the Cancer Cell Line
RT   Encyclopedia.";
RL   Nature 569:503-508(2019).
//