ID   B2-17
AC   CVCL_2864
DR   CLO; CLO_0009881
DR   ArrayExpress; E-MTAB-783
DR   BioSample; SAMN03151975
DR   cancercelllines; CVCL_2864
DR   Cell_Model_Passport; SIDM00110
DR   Cosmic; 911904
DR   Cosmic; 2367508
DR   IARC_TP53; 21180
DR   JCRB; IFO50361
DR   LINCS_LDP; LCL-1367
DR   Wikidata; Q54752556
RX   CelloPub=CLPUB00152;
RX   PubMed=20164919;
CC   Population: Caucasian.
CC   Doubling time: 48 hours (CelloPub=CLPUB00152).
CC   Selected for resistance to: ChEBI; CHEBI:472552; 5-bromo-2'-deoxyuridine (Bromodeoxyuridine; BrdU; BUdR).
CC   Sequence variation: Mutation; HGNC; 9588; PTEN; Simple; p.Glu242Valfs*15 (c.723_724dupTG); ClinVar=VCV000536553; Zygosity=Unspecified (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Arg273His (c.818G>A); ClinVar=VCV000012366; Zygosity=Unspecified (from parent cell line).
CC   Omics: SNP array analysis.
CC   Omics: Transcriptome analysis by microarray.
CC   Caution: Was incorrectly reported to be a U-251MG contaminated cell line by ICLAC while it was specifically derived from U-251MG as described in the original publication (CelloPub=CLPUB00152).
CC   Derived from site: In situ; Brain, parietal lobe; UBERON=UBERON_0001872.
ST   Source(s): JCRB
ST   Amelogenin: X
ST   CSF1PO: 11,12
ST   D13S317: 10,11
ST   D16S539: 12
ST   D5S818: 11,12
ST   D7S820: 10,12
ST   TH01: 9.3
ST   TPOX: 8
ST   vWA: 16,18
DI   NCIt; C60781; Astrocytoma
DI   ORDO; Orphanet_94; Astrocytoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0021 ! U-251MG
SX   Male
AG   75Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 05-10-23; Version: 27
//
RX   CelloPub=CLPUB00152;
RA   Takeshita I., Takaki T., Nakamura T., Maeyama R., Fukui M.,
RA   Kitamura K.;
RT   "Established cell lines derived from human gliomas.";
RL   Hum. Cell 3:255-256(1990).
//
RX   PubMed=20164919; DOI=10.1038/nature08768;
RA   Bignell G.R., Greenman C.D., Davies H., Butler A.P., Edkins S.,
RA   Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S.,
RA   Hinton J., Fahey C., Fu B.-Y., Swamy S., Dalgliesh G.L., Teh B.T.,
RA   Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.;
RT   "Signatures of mutation and selection in the cancer genome.";
RL   Nature 463:893-898(2010).
//