Cellosaurus HARA [Human squamous cell lung carcinoma] (CVCL_2914)

Cell line name HARA [Human squamous cell lung carcinoma]
Synonyms KCC-C1
Accession CVCL_2914
Resource Identification Initiative To cite this cell line use: HARA [Human squamous cell lung carcinoma] (RRID:CVCL_2914)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Characteristics: Produces high level of parathyroid hormone-related peptide (PTHrP).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Deep exome analysis.
Omics: DNA methylation analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Disease Squamous cell lung carcinoma (NCIt: C3493)
Derived from metastatic site: Pleural effusion.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children: CVCL_2915 (HARA-B); CVCL_JG55 (HARA/CMV-Luc)
Sex of cell Male
Category Cancer cell line
STR profile Source(s): Cosmic-CLP; JCRB

Markers:
AmelogeninX,Y
CSF1PO13
D13S3179
D16S53910
D5S81812
D7S82012
TH017
TPOX8,9
vWA16,17
Publications

PubMed=8287365; DOI=10.1016/0304-3835(93)90053-C
Ichinose Y., Iguchi H., Ohta M., Katakami H.
Establishment of lung cancer cell line producing parathyroid hormone-related protein.
Cancer Lett. 74:119-124(1993)

PubMed=8752176
Iguchi H., Tanaka S., Ozawa Y., Kashiwakuma T., Kimura T., Hiraga T., Ozawa H., Kono A.
An experimental model of bone metastasis by human lung cancer cells: the role of parathyroid hormone-related protein in bone metastasis.
Cancer Res. 56:4040-4043(1996)

PubMed=12569360; DOI=10.1038/sj.onc.1206106
Funakoshi T., Tachibana I., Hoshida Y., Kimura H., Takeda Y., Kijima T., Nishino K., Goto H., Yoneda T., Kumagai T., Osaki T., Hayashi S., Aozasa K., Kawase I.
Expression of tetraspanins in human lung cancer cells: frequent downregulation of CD9 and its contribution to cell motility in small cell lung cancer.
Oncogene 22:674-687(2003)

PubMed=22460905; DOI=10.1038/nature11003
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.K., Yu J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L., Winckler W., Reich M., Li N., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

Cross-references
Cell line collections JCRB; JCRB1080.0
JCRB; NIHS0352.0 - Discontinued
Cell line databases/resources CCLE; HARA_LUNG
Cosmic-CLP; 1240142
GDSC; 1240142
LINCS_LDP; LCL-1585
Biological sample resources BioSample; SAMN03472500
Gene expression databases GEO; GSM827377
GEO; GSM887032
GEO; GSM888102
GEO; GSM1374487
GEO; GSM1669839
Polymorphism and mutation databases Cosmic; 1995421
Cosmic; 2060530