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Cellosaurus HEC-251 (CVCL_2927)

[Text version]

Cell line name HEC-251
Synonyms HEC251
Accession CVCL_2927
Resource Identification Initiative To cite this cell line use: HEC-251 (RRID:CVCL_2927)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Part of: MD Anderson Cell Lines Project.
Doubling time: 36 hours, at 3rd passage (PubMed=15171304); 30 hours (DOI=10.1007/978-4-431-53981-0_1).
Omics: Deep exome analysis.
Omics: Deep RNAseq analysis.
Omics: Protein expression by reverse-phase protein arrays.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Sequence variations TP53 p.Gly154Asp (c.461G>A) (PubMed=15053063).
Genome ancestry Source: PubMed=30894373

Origin% genome
African0
Native American0.73
East Asian, North78.55
East Asian, South20.72
South Asian0
European, North0
European, South0
Disease Endometrial carcinoma (NCIt: C7558)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 53Y
Category Cancer cell line
STR profile Source(s): JCRB; PubMed=25877200

Markers:
AmelogeninX
CSF1PO9,11
D2S133816,19
D3S135815,16
D5S8189,12
D7S82011
D8S117910,13
D13S31711
D16S5399
D18S5113,20
D19S43314,15
D21S1130,31.2
FGA20,21
Penta D9,10
Penta E5,15
TH017
TPOX8,11
vWA14

Run an STR similarity search on this cell line
Web pages http://tcpaportal.org/mclp/
Publications

DOI=10.1007/978-4-431-53981-0_1
Kuramoto H., Hamano M., Imai M., Fujisawa T., Kamata Y., Arai T., Kawaguchi M.
HEC-1 cells: establishment of an in vitro experimental system in endometrial carcinoma.
(In) Cell and molecular biology of endometrial carcinoma; Kuramoto H., Nishida M. (eds.); pp.3-34; Springer; Tokyo (2003)

PubMed=15053063
Kamata Y., Watanabe J., Hata H., Hamano M., Kuramoto H.
Quantitative study on the correlation between p53 gene mutation and its expression in endometrial carcinoma cell lines.
Eur. J. Gynaecol. Oncol. 25:55-60(2004)

PubMed=15171304
Fujisawa T., Hamano M., Hata H., Kamata Y., Watanabe J., Sekimoto R., Kuramoto H.
Establishment and characterization of two different types of new human endometrial adenocarcinoma cell lines (HEC-251 and HEC-265).
Eur. J. Gynaecol. Oncol. 25:299-304(2004)

PubMed=22460905; DOI=10.1038/nature11003
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.K., Yu J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005
Li J., Zhao W., Akbani R., Liu W., Ju Z., Ling S., Vellano C.P., Roebuck P., Yu Q., Eterovic A.K., Byers L.A., Davies M.A., Deng W., Gopal Y.N.V., Chen G., von Euw E.M., Slamon D.J., Conklin D., Heymach J.V., Gazdar A.F., Minna J.D., Myers J.N., Lu Y., Mills G.B., Liang H.
Characterization of human cancer cell lines by reverse-phase protein arrays.
Cancer Cell 31:225-239(2017)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z., Monteiro A.N., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3
Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. III, Barretina J., Gelfand E.T., Bielski C.M., Li H., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R.
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

Cross-references
Cell line collections JCRB; JCRB1141
Cell line databases/resources CCLE; HEC251_ENDOMETRIUM
Cell_Model_Passport; SIDM01611
DepMap; ACH-000996
Biological sample resources BioSample; SAMD00048820
BioSample; SAMN03470931
BioSample; SAMN10987959
Chemistry resources PharmacoDB; HEC251_527_2019
Gene expression databases ArrayExpress; E-MTAB-2770
GEO; GSM887071
GEO; GSM888141
Other Wikidata; Q54882261
Polymorphism and mutation databases Cosmic; 2030469
IARC_TP53; 20593
LiGeA; CCLE_436
Entry history
Entry creation04-Apr-2012
Last entry updated06-Sep-2019
Version number21