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Cellosaurus HMC-1-8 (CVCL_2949)

[Text version]

Cell line name HMC-1-8
Synonyms HMC18
Accession CVCL_2949
Resource Identification Initiative To cite this cell line use: HMC-1-8 (RRID:CVCL_2949)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Population: Japanese.
Doubling time: 26 hours (DOI=10.15114/tr.22.27).
Omics: Deep exome analysis.
Omics: Deep RNAseq analysis.
Sequence variations Heterozygous for KRAS p.Gly12Val (c.35G>T) (ClinVar=VCV000012583) (CCLE).
TP53 p.Pro152Argfs*18 (c.455delC) (ClinVar=VCV000634779) (CCLE).
Genome ancestry Source: PubMed=30894373

Origin% genome
Native American0
East Asian, North83.08
East Asian, South16.92
South Asian0
European, North0
European, South0
Disease Breast carcinoma (NCIt: C4872)
Derived from metastatic site: Pleural effusion.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_H204 ! TcHMC-1
Sex of cell Female
Age at sampling 35Y
Category Cancer cell line
STR profile Source(s): JCRB


Run an STR similarity search on this cell line

Sato T., Sato N., Takahashi S., Koshiba H., Kikuchi K.
Specific cytotoxicity of a long-term cultured T-cell clone on human autologous mammary cancer cells.
Cancer Res. 46:4384-4389(1986)

Sato T., Sato N., Takahashi S., Okubo M., Yagihashi A., Okazaki A., Okazaki Y., Toda K.
Characterization of two new cancer cell lines derived from human breast tumors.
Tumor Res. 22:27-39(1987)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z., Monteiro A.N., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3
Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. III, Barretina J., Gelfand E.T., Bielski C.M., Li H., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R.
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

Cell line collections JCRB; JCRB0166
JCRB; FDSC0048 - Discontinued
Cell line databases/resources CCLE; HMC18_BREAST
Cell_Model_Passport; SIDM01622
DepMap; ACH-000721
Ontologies CLO; CLO_0037257
Biological sample resources BioSample; SAMN03470817
BioSample; SAMN10987868
Chemistry resources PharmacoDB; HMC18_552_2019
Gene expression databases ArrayExpress; E-MTAB-2770
Other Wikidata; Q54889908
Polymorphism and mutation databases IARC_TP53; 28374
LiGeA; CCLE_562
Progenetix; CVCL_2949
Entry history
Entry creation04-Apr-2012
Last entry update29-Oct-2020
Version number17