ID   HMC-1-8
AC   CVCL_2949
SY   HMC18
DR   CLO; CLO_0037257
DR   ArrayExpress; E-MTAB-2770
DR   BioSample; SAMN03470817
DR   BioSample; SAMN10987868
DR   CCLE; HMC18_BREAST
DR   Cell_Model_Passport; SIDM01622
DR   DepMap; ACH-000721
DR   IARC_TP53; 28374
DR   JCRB; JCRB0166
DR   JCRB; FDSC0048
DR   LiGeA; CCLE_562
DR   PharmacoDB; HMC18_552_2019
DR   Wikidata; Q54889908
RX   DOI=10.15114/tr.22.27;
RX   PubMed=3488124;
RX   PubMed=30894373;
RX   PubMed=31068700;
CC   Part of: Cancer Cell Line Encyclopedia (CCLE) project.
CC   Doubling time: 26 hours (DOI=10.15114/tr.22.27).
CC   Sequence variation: Heterozygous for KRAS p.Gly12Val (c.35G>T) (CCLE).
CC   Sequence variation: TP53 p.Pro152fs*18 (c.455delC) (CCLE).
CC   Omics: Deep exome analysis.
CC   Omics: Deep RNAseq analysis.
CC   Genome ancestry: African=0%; Native American=0%; East Asian, North=83.08%; East Asian, South=16.92%; South Asian=0%; European, North=0%; European, South=0% (PubMed=30894373).
CC   Discontinued: JCRB; FDSC0048; true.
CC   Derived from metastatic site: Pleural effusion.
ST   Source(s): JCRB
ST   Amelogenin: X
ST   CSF1PO: 7,12
ST   D13S317: 8,10
ST   D16S539: 9,12
ST   D5S818: 9,10
ST   D7S820: 11
ST   TH01: 7,9
ST   TPOX: 8,12
ST   vWA: 16,17
DI   NCIt; C4872; Breast carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens
OI   CVCL_H204 ! TcHMC-1
SX   Female
AG   35Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 06-09-19; Version: 15
//
RX   DOI=10.15114/tr.22.27;
RA   Sato T., Sato N., Takahashi S., Okubo M., Yagihashi A., Okazaki A.,
RA   Okazaki Y., Toda K.;
RT   "Characterization of two new cancer cell lines derived from human
RT   breast tumors.";
RL   Tumor Res. 22:27-39(1987).
//
RX   PubMed=3488124;
RA   Sato T., Sato N., Takahashi S., Koshiba H., Kikuchi K.;
RT   "Specific cytotoxicity of a long-term cultured T-cell clone on human
RT   autologous mammary cancer cells.";
RL   Cancer Res. 46:4384-4389(1986).
//
RX   PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747;
RA   Dutil J., Chen Z., Monteiro A.N., Teer J.K., Eschrich S.A.;
RT   "An interactive resource to probe genetic diversity and estimated
RT   ancestry in cancer cell lines.";
RL   Cancer Res. 79:1263-1273(2019).
//
RX   PubMed=31068700; DOI=10.1038/s41586-019-1186-3;
RA   Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C.,
RA   McDonald E.R. III, Barretina J., Gelfand E.T., Bielski C.M., Li H.,
RA   Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F.,
RA   Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R.,
RA   Lu Y., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C.,
RA   Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A.,
RA   Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D.,
RA   Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L.,
RA   Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A.,
RA   Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D.,
RA   Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M.,
RA   Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R.,
RA   Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A.,
RA   Sellers W.R.;
RT   "Next-generation characterization of the Cancer Cell Line
RT   Encyclopedia.";
RL   Nature 569:503-508(2019).
//