Home  |  Contact

Cellosaurus IHH-4 (CVCL_2960)

[Text version]

Cell line name IHH-4
Synonyms IHH4
Accession CVCL_2960
Resource Identification Initiative To cite this cell line use: IHH-4 (RRID:CVCL_2960)
Comments Part of: Cancer Cell Line Encyclopedia (CCLE) project.
Part of: COSMIC cell lines project.
Doubling time: 42 hours (PubMed=11686581).
Microsatellite instability: Stable (MSS) (Sanger).
Omics: Deep exome analysis.
Omics: DNA methylation analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis.
Sequence variations AKT1 p.Glu17Lys (c.49G>A) (PubMed=23833040; PubMed=30737244).
BRAF p.Val600Glu (c.1799T>A) (PubMed=23833040; PubMed=30737244).
CREBBP p.Trp592Ter (c.1776G>A) (PubMed=30737244).
CRLF2 p.Trp255Ter (c.765G>A) (PubMed=30737244).
EP300 p.Arg1312Ter (c.3934C>T) (PubMed=30737244).
RAC1 p.Asp11Glu (c.33C>G) (PubMed=30737244).
Heterozygous for TERT c.228C>T (-124C>T); in promoter (PubMed=23833040; PubMed=30737244).
Genome ancestry Source: PubMed=30894373

Origin% genome
African1.71
Native American0
East Asian, North73.08
East Asian, South21.44
South Asian0
European, North0.89
European, South2.88
Disease Thyroid gland papillary carcinoma (NCIt: C4035)
Derived from metastatic site: Left cervical lymph node.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_3219 (TMH-1)
Sex of cell Male
Age at sampling 75Y
Category Cancer cell line
STR profile Source(s): Cosmic-CLP; JCRB; PubMed=30737244

Markers:
AmelogeninX,Y
CSF1PO12
D3S135816
D5S8189,13
D7S8209,10
D8S117911,15
D13S31710,13
D16S5399,11
D18S5113,15
D21S1130,31
FGA23,24
TH019
TPOX11
vWA16,18

Run an STR similarity search on this cell line
Publications

PubMed=11686581; DOI=10.1016/S0753-3322(01)00087-7
Sekiguchi M., Shiroko Y., Arai T., Kishino T., Sugawara I., Kusakabe T., Suzuki T., Yamashita T., Obara T., Ito K., Hasumi K.
Biological characteristics and chemosensitivity profile of four human anaplastic thyroid carcinoma cell lines.
Biomed. Pharmacother. 55:466-474(2001)

PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458
Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A.
A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
Cancer Res. 70:2158-2164(2010)

PubMed=23833040; DOI=10.1210/jc.2013-2383
Landa I., Ganly I., Chan T.A., Mitsutake N., Matsuse M., Ibrahimpasic T., Ghossein R.A., Fagin J.A.
Frequent somatic TERT promoter mutations in thyroid cancer: higher prevalence in advanced forms of the disease.
J. Clin. Endocrinol. Metab. 98:E1562-E1566(2013)

PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
A landscape of pharmacogenomic interactions in cancer.
Cell 166:740-754(2016)

PubMed=30737244; DOI=10.1158/1078-0432.CCR-18-2953
Landa I., Pozdeyev N., Korch C., Marlow L.A., Smallridge R.C., Copland J.A., Henderson Y.C., Lai S.Y., Clayman G.L., Onoda N., Tan A.C., Garcia-Rendueles M.E.R., Knauf J.A., Haugen B.R., Fagin J.A., Schweppe R.E.
Comprehensive genetic characterization of human thyroid cancer cell lines: a validated panel for preclinical studies.
Clin. Cancer Res. 25:3141-3151(2019)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z., Monteiro A.N., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

Cross-references
Cell line collections JCRB; JCRB1079
JCRB; NIHS0270 - Discontinued
JCRB; NIHS0270.1 - Discontinued
JCRB; NIHS0271.1 - Discontinued
Cell line databases/resources CCLE; IHH4_THYROID
Cell_Model_Passport; SIDM00600
Cosmic-CLP; 1240154
DepMap; ACH-001528
GDSC; 1240154
LINCS_LDP; LCL-1693
Biological sample resources BioSample; SAMN03481111
Chemistry resources PharmacoDB; IHH4_655_2019
Gene expression databases ArrayExpress; E-MTAB-3610
GEO; GSM827172
GEO; GSM1669931
Other Wikidata; Q54897412
Polymorphism and mutation databases Cosmic; 1995454
Cosmic; 2054088
Entry history
Entry creation04-Apr-2012
Last entry updated06-Sep-2019
Version number24