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Cellosaurus KAI3 (CVCL_2969)

Cell line name KAI3
Accession CVCL_2969
Resource Identification Initiative To cite this cell line use: KAI3 (RRID:CVCL_2969)
Comments Population: Japanese.
Characteristics: IL2 dependent.
Doubling time: 3.5 days (Note=Lot 03082007), ~76 hours (Note=Lot 07312015) (JCRB=IFO50518).
Karyotypic information: 46,XY,add(6)(p23),der(6)add(6)(p23)add(6)(q21) (PubMed=10193407).
Transformant: NCBI_TaxID; 10376; Epstein-Barr virus (EBV).
Omics: Transcriptome analysis by microarray.
Omics: Transcriptome analysis by RNAseq.
Donor information: Established from a donor with severe hypersensitivity to mosquito bite (HMB) (PubMed=10193407).
Misspelling: KA13; Cosmic=2390216.
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Cell type: Natural killer cell; CL=CL_0000623.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 13Y
Category Transformed cell line
STR profile Source(s): JCRB

Markers:
AmelogeninX,Y
CSF1PO12
D5S81811
D7S82010,12
D13S3178,11
D16S5399,10
TH018,9
TPOX8,11
vWA17,18

Run an STR similarity search on this cell line
Publications

PubMed=10193407; DOI=10.1046/j.1365-2249.1999.00836.x
Tsuge I., Morishima T., Morita M., Kimura H., Kuzushima K., Matsuoka H.
Characterization of Epstein-Barr virus (EBV)-infected natural killer (NK) cell proliferation in patients with severe mosquito allergy establishment of an IL-2-dependent NK-like cell line.
Clin. Exp. Immunol. 115:385-392(1999)

PubMed=19194464; DOI=10.1038/leu.2009.3
Iqbal J., Kucuk C., Deleeuw R.J., Srivastava G., Tam W., Geng H., Klinkebiel D., Christman J.K., Patel K., Cao K., Shen L., Dybkaer K., Tsui I.F.L., Ali H., Shimizu N., Au W.Y., Lam W.L., Chan W.C.
Genomic analyses reveal global functional alterations that promote tumor growth and novel tumor suppressor genes in natural killer-cell malignancies.
Leukemia 23:1139-1151(2009)

PubMed=21052088; DOI=10.1038/leu.2010.255
Iqbal J., Weisenburger D.D., Chowdhury A., Tsai M.Y., Srivastava G., Greiner T.C., Kucuk C., Deffenbacher K., Vose J.M., Smith L., Au W.Y., Nakamura S., Seto M., Delabie J., Berger F., Loong F., Ko Y.-H., Sng I., Liu X., Loughran T.P. Jr., Armitage J.O., Chan W.C.
Natural killer cell lymphoma shares strikingly similar molecular features with a group of non-hepatosplenic gammadelta T-cell lymphoma and is highly sensitive to a novel aurora kinase A inhibitor in vitro.
Leukemia 25:348-358(2011)

PubMed=25586472; DOI=10.1038/ncomms7025
Kucuk C., Jiang B., Hu X.-Z., Zhang W.-Y., Chan J.K.C., Xiao W.-M., Lack N., Alkan C., Williams J.C., Avery K.N., Kavak P., Scuto A., Sen E., Gaulard P., Staudt L.M., Iqbal J., Zhang W.-W., Cornish A., Gong Q., Yang Q.-P., Sun H., d'Amore F.A., Leppa S., Liu W.-P., Fu K., de Leval L., McKeithan T.W., Chan W.C.
Activating mutations of STAT5B and STAT3 in lymphomas derived from gammadelta-T or NK cells.
Nat. Commun. 6:6025.1-6025.12(2015)

PubMed=29892436; DOI=10.1098/rsos.172472
Shioda S., Kasai F., Watanabe K., Kawakami K., Ohtani A., Iemura M., Ozawa M., Arakawa A., Hirayama N., Kawaguchi E., Tano T., Miyata S., Satoh M., Shimizu N., Kohara A.
Screening for 15 pathogenic viruses in human cell lines registered at the JCRB Cell Bank: characterization of in vitro human cells by viral infection.
R. Soc. Open Sci. 5:172472-172472(2018)

PubMed=36094314; DOI=10.1128/JVI.00739-22
Ding W.-Y., Wang C., Narita Y., Wang H.-B., Leong M.M.L., Huang A., Liao Y.-F., Liu X.-F., Okuno Y., Kimura H., Gewurz B.E., Teng M.-X., Jin S.-L., Sato Y., Zhao B.
The Epstein-Barr virus enhancer interaction landscapes in virus-associated cancer cell lines.
J. Virol. 96:e0073922.1-e0073922.11(2022)

Cross-references
Cell line collections (Providers) JCRB; IFO50518
Biological sample resources BioSample; SAMN03472803
Encyclopedic resources Wikidata; Q54899458
Gene expression databases GEO; GSM471999
Polymorphism and mutation databases Cosmic; 1542077
Cosmic; 2390216
Entry history
Entry creation04-Apr-2012
Last entry update29-Jun-2023
Version number19