Cellosaurus logo
expasy logo

Cellosaurus KHM-5M (CVCL_2975)

[Text version]
Cell line name KHM-5M
Synonyms KHM/5M; KHM5M
Accession CVCL_2975
Resource Identification Initiative To cite this cell line use: KHM-5M (RRID:CVCL_2975)
Comments Population: Japanese.
Doubling time: 27 hours (Note=Lot 09272002) (JCRB=JCRB0148).
Omics: Transcriptome analysis by microarray.
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Mutation; HGNC; 1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (PubMed=23833040; PubMed=30737244).
  • Mutation; HGNC; 11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Heterozygous; Note=In promoter (PubMed=23833040; PubMed=30737244).
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg280Thr (c.839G>C); ClinVar=VCV000012368; Zygosity=Homozygous (PubMed=30737244).
Disease Thyroid gland anaplastic carcinoma (NCIt: C3878)
Anaplastic thyroid carcinoma (ORDO: Orphanet_142)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 65Y
Category Cancer cell line
STR profile Source(s): JCRB; PubMed=25877200; PubMed=30737244

Markers:
AmelogeninX,Y
CSF1PO11.3,12.3 (JCRB)
12,13 (PubMed=25877200; PubMed=30737244)
D2S133819,23
D3S135815
D5S81812
D7S82010,11
D8S117913
D13S3178,11
D16S5399,10
D18S5116,19
D19S43314
D21S1128,31
FGA22,23
Penta D9,11
Penta E11,18
TH017
TPOX8
vWA18

Run an STR similarity search on this cell line
Publications

PubMed=1728417
Yoshida M., Matsuzaki H., Sakata K., Takeya M., Kato K., Mizushima S., Kawakita M., Takatsuki K.
Neutrophil chemotactic factors produced by a cell line from thyroid carcinoma.
Cancer Res. 52:464-469(1992)

PubMed=16924234; DOI=10.1038/sj.onc.1209899
Yu W., Imoto I., Inoue J., Onda M., Emi M., Inazawa J.
A novel amplification target, DUSP26, promotes anaplastic thyroid cancer cell growth by inhibiting p38 MAPK activity.
Oncogene 26:1178-1187(2007)

PubMed=23833040; DOI=10.1210/jc.2013-2383
Landa I., Ganly I., Chan T.A., Mitsutake N., Matsuse M., Ibrahimpasic T., Ghossein R.A., Fagin J.A.
Frequent somatic TERT promoter mutations in thyroid cancer: higher prevalence in advanced forms of the disease.
J. Clin. Endocrinol. Metab. 98:E1562-E1566(2013)

PubMed=25877200; DOI=10.1038/nature14397
Yu M., Selvaraj S.K., Liang-Chu M.M.Y., Aghajani S., Busse M., Yuan J., Lee G., Peale F.V., Klijn C., Bourgon R., Kaminker J.S., Neve R.M.
A resource for cell line authentication, annotation and quality control.
Nature 520:307-311(2015)

PubMed=30737244; DOI=10.1158/1078-0432.CCR-18-2953
Landa I., Pozdeyev N., Korch C.T., Marlow L.A., Smallridge R.C., Copland J.A. III, Henderson Y.C., Lai S.Y., Clayman G.L., Onoda N., Tan A.-C., Garcia-Rendueles M.E.R., Knauf J.A., Haugen B.R., Fagin J.A., Schweppe R.E.
Comprehensive genetic characterization of human thyroid cancer cell lines: a validated panel for preclinical studies.
Clin. Cancer Res. 25:3141-3151(2019)

Cross-references
Cell line collections (Providers) CLS; 305148
JCRB; JCRB0148
JCRB; NIHS0194 - Discontinued
Cell line databases/resources cancercelllines; CVCL_2975
CCRID; 3101HUMSCSP549
CGH-DB; 57-1
Biological sample resources BioSample; SAMN03470813
BioSample; SAMN03470887
Encyclopedic resources Wikidata; Q54899907
Polymorphism and mutation databases Cosmic; 2054085
Entry history
Entry creation04-Apr-2012
Last entry update05-Oct-2023
Version number25